Contemporary nuclear medicine diagnostics of neuroendocrine tumors
The new positron emission tomography (PET/CT) methods for neuroendocrine tumors detection are presented and compared with classic, conventional methods. Conventional methods use a gamma scintillation camera for patients with neuroendocrine tumor imaging, after intravenous injection of one o...
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| Format: | Article |
| Language: | English |
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Serbian Medical Society
2015-01-01
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| Series: | Srpski Arhiv za Celokupno Lekarstvo |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0370-8179/2015/0370-81791502108T.pdf |
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| author | Todorović-Tirnanić Mila Artiko Vera Pavlović Smiljana Šobić-Šaranović Dragana Obradović Vladimir |
| author_facet | Todorović-Tirnanić Mila Artiko Vera Pavlović Smiljana Šobić-Šaranović Dragana Obradović Vladimir |
| author_sort | Todorović-Tirnanić Mila |
| collection | DOAJ |
| description | The new positron emission tomography (PET/CT) methods for neuroendocrine
tumors detection are presented and compared with classic, conventional
methods. Conventional methods use a gamma scintillation camera for patients
with neuroendocrine tumor imaging, after intravenous injection of one of the
following radiopharmaceuticals: 1) somatostatin analogues labeled with
indium-111 (111In-pentetreotide) or technetium-99m (99mTc-EDDA/HYNIC-TOC); 2)
noradrenaline analogue labeled with iodine-131 or -123 (131I/123I-MIBG); or
3) 99mTc(V)-DMSA. Contemporary methods use PET/CT equipment for patients with
neuroendocrine tumor imaging, after intravenous injection of pharmaceuticals
labeled with positron emitters [fluorine-18 (18F), galium-68 (68Ga), or
carbon-11 (11C)]: 1) glucose analogue (18FDG); 2) somatostatin analogue
(68Ga-DOTATOC/68Ga-DOTATATE/68Ga-DOTANOC); 3) aminoacid precursors of
bioamines: [a) dopamine precursor 18F-DOPA (6-18F-dihydroxyphenylalanine), b)
serotonin precursor 11C-5HTP (11C-5-hydroxytryptophan)]; or 4) dopamine
analogue 18F-DA (6-18F-fluorodopamine). Conventional and contemporary (PET/
CT) somatostatin receptor detection showed identical high specificity (92%),
but conventional had very low sensitivity (52%) compared to PET/CT (97%). It
means that almost every second neuroendocrine tumor detected by contemporary
method cannot be discovered using conventional (classic) method. In
metastatic pheochromocytoma detection contemporary (PET/ CT) methods
(18F-DOPA and 18F-DA) have higher sensitivity than conventional
(131I/123I-MIBG). In medullary thyroid carcinoma diagnostics contemporary
method (18F-DOPA) is more sensitive than conventional 99mTc(V)-DMSA method,
and is similar to 18FDG, computed tomography and magnetic resonance. In
carcinoid detection contemporary method (18F-DOPA) shows similar results with
contemporary somatostatin receptor detection, while for
gastroenteropancreatic neuroendocrine tumors it is worse. To conclude,
contemporary (PET/CT) methods for somatostatin receptor detection
(68Ga-DOTATOC/-NOC/-TATE) in neuroendocrine tumors are much more sensitive
(almost twice) and more accurate than conventional. Therefore the classical
methods should be urgently replaced by contemporary methods. |
| first_indexed | 2024-12-14T21:25:29Z |
| format | Article |
| id | doaj.art-546c32e79f4e46e3807d9fe3dd9981ac |
| institution | Directory Open Access Journal |
| issn | 0370-8179 |
| language | English |
| last_indexed | 2024-12-14T21:25:29Z |
| publishDate | 2015-01-01 |
| publisher | Serbian Medical Society |
| record_format | Article |
| series | Srpski Arhiv za Celokupno Lekarstvo |
| spelling | doaj.art-546c32e79f4e46e3807d9fe3dd9981ac2022-12-21T22:46:51ZengSerbian Medical SocietySrpski Arhiv za Celokupno Lekarstvo0370-81792015-01-011431-210811510.2298/SARH1502108T0370-81791502108TContemporary nuclear medicine diagnostics of neuroendocrine tumorsTodorović-Tirnanić Mila0Artiko Vera1Pavlović Smiljana2Šobić-Šaranović Dragana3Obradović Vladimir4School of Medicine, Belgrade + Clinical Center of Serbia, Center for Nuclear Medicine, BelgradeSchool of Medicine, Belgrade + Clinical Center of Serbia, Center for Nuclear Medicine, BelgradeSchool of Medicine, Belgrade + Clinical Center of Serbia, Center for Nuclear Medicine, BelgradeSchool of Medicine, Belgrade + Clinical Center of Serbia, Center for Nuclear Medicine, BelgradeSchool of Medicine, Belgrade + Clinical Center of Serbia, Center for Nuclear Medicine, BelgradeThe new positron emission tomography (PET/CT) methods for neuroendocrine tumors detection are presented and compared with classic, conventional methods. Conventional methods use a gamma scintillation camera for patients with neuroendocrine tumor imaging, after intravenous injection of one of the following radiopharmaceuticals: 1) somatostatin analogues labeled with indium-111 (111In-pentetreotide) or technetium-99m (99mTc-EDDA/HYNIC-TOC); 2) noradrenaline analogue labeled with iodine-131 or -123 (131I/123I-MIBG); or 3) 99mTc(V)-DMSA. Contemporary methods use PET/CT equipment for patients with neuroendocrine tumor imaging, after intravenous injection of pharmaceuticals labeled with positron emitters [fluorine-18 (18F), galium-68 (68Ga), or carbon-11 (11C)]: 1) glucose analogue (18FDG); 2) somatostatin analogue (68Ga-DOTATOC/68Ga-DOTATATE/68Ga-DOTANOC); 3) aminoacid precursors of bioamines: [a) dopamine precursor 18F-DOPA (6-18F-dihydroxyphenylalanine), b) serotonin precursor 11C-5HTP (11C-5-hydroxytryptophan)]; or 4) dopamine analogue 18F-DA (6-18F-fluorodopamine). Conventional and contemporary (PET/ CT) somatostatin receptor detection showed identical high specificity (92%), but conventional had very low sensitivity (52%) compared to PET/CT (97%). It means that almost every second neuroendocrine tumor detected by contemporary method cannot be discovered using conventional (classic) method. In metastatic pheochromocytoma detection contemporary (PET/ CT) methods (18F-DOPA and 18F-DA) have higher sensitivity than conventional (131I/123I-MIBG). In medullary thyroid carcinoma diagnostics contemporary method (18F-DOPA) is more sensitive than conventional 99mTc(V)-DMSA method, and is similar to 18FDG, computed tomography and magnetic resonance. In carcinoid detection contemporary method (18F-DOPA) shows similar results with contemporary somatostatin receptor detection, while for gastroenteropancreatic neuroendocrine tumors it is worse. To conclude, contemporary (PET/CT) methods for somatostatin receptor detection (68Ga-DOTATOC/-NOC/-TATE) in neuroendocrine tumors are much more sensitive (almost twice) and more accurate than conventional. Therefore the classical methods should be urgently replaced by contemporary methods.http://www.doiserbia.nb.rs/img/doi/0370-8179/2015/0370-81791502108T.pdfneuroendocrine tumors68Ga-DOTATOC18F-DOPA18FDG6-18F-fluorodopamine11C-5-hydroxytryptophan |
| spellingShingle | Todorović-Tirnanić Mila Artiko Vera Pavlović Smiljana Šobić-Šaranović Dragana Obradović Vladimir Contemporary nuclear medicine diagnostics of neuroendocrine tumors Srpski Arhiv za Celokupno Lekarstvo neuroendocrine tumors 68Ga-DOTATOC 18F-DOPA 18FDG 6-18F-fluorodopamine 11C-5-hydroxytryptophan |
| title | Contemporary nuclear medicine diagnostics of neuroendocrine tumors |
| title_full | Contemporary nuclear medicine diagnostics of neuroendocrine tumors |
| title_fullStr | Contemporary nuclear medicine diagnostics of neuroendocrine tumors |
| title_full_unstemmed | Contemporary nuclear medicine diagnostics of neuroendocrine tumors |
| title_short | Contemporary nuclear medicine diagnostics of neuroendocrine tumors |
| title_sort | contemporary nuclear medicine diagnostics of neuroendocrine tumors |
| topic | neuroendocrine tumors 68Ga-DOTATOC 18F-DOPA 18FDG 6-18F-fluorodopamine 11C-5-hydroxytryptophan |
| url | http://www.doiserbia.nb.rs/img/doi/0370-8179/2015/0370-81791502108T.pdf |
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