Systemic IL-26 correlates with improved asthma control in children sensitized to dog allergen
Abstract Background Interleukin (IL)-26 is produced by T helper type 17 (Type 17) cells and exerts immunomodulatory plus antimicrobial effects. Previous studies show that local IL-26 concentrations in the airways are higher in patients with uncontrolled than in those with controlled asthma, and that...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-04-01
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| Series: | Respiratory Research |
| Online Access: | https://doi.org/10.1186/s12931-024-02773-7 |
| _version_ | 1797199255382786048 |
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| author | Melissa A. Kovach Ulrika Käck Karlhans F Che Bettina Brundin Jon R. Konradsen Anders Lindén |
| author_facet | Melissa A. Kovach Ulrika Käck Karlhans F Che Bettina Brundin Jon R. Konradsen Anders Lindén |
| author_sort | Melissa A. Kovach |
| collection | DOAJ |
| description | Abstract Background Interleukin (IL)-26 is produced by T helper type 17 (Type 17) cells and exerts immunomodulatory plus antimicrobial effects. Previous studies show that local IL-26 concentrations in the airways are higher in patients with uncontrolled than in those with controlled asthma, and that this intriguing cytokine bears biomarker potential. Here, we determined how systemic IL-26 relates to allergen sensitization, asthma severity, and to IL-17 A in children. Methods Serum samples were obtained from children with (n = 60) and without (n = 17) sensitization to dog allergen, and IL-26 and IL-17 A protein concentrations were measured using ELISA. Self-reported history, including medication use and validated symptom-based questionnaire scores, was recorded. Results The serum concentrations of IL-26 were enhanced in allergen-sensitized subjects and correlated with those of IL-17 A in a positive manner. However, the IL-26 concentrations did not markedly differ between allergen-sensitized subjects with and without asthma, eczema, allergic rhinitis, or a history of food allergy. Notably, IL-26 concentrations correlated with increasing Asthma Control Test (ACT) scores in a positive manner and with inhaled corticosteroid in a negative manner, amongst sensitized subjects with asthma. Moreover, subjects with asthma requiring ≥ 1 course of oral corticosteroids in the preceding 12 months had decreased IL-26 concentrations. Conclusion This study forwards evidence that systemic IL-26, just like IL-17 A, is involved in allergen sensitization among children. The association of systemic IL-26 with improved asthma control is compatible with the cellular sources being recruited into the airways in severe asthma, which supports that this kinocidin bears potential as a biomarker and therapeutic target. |
| first_indexed | 2024-04-24T07:12:51Z |
| format | Article |
| id | doaj.art-546e097d907c490c9815d6725b2f38fa |
| institution | Directory Open Access Journal |
| issn | 1465-993X |
| language | English |
| last_indexed | 2024-04-24T07:12:51Z |
| publishDate | 2024-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Respiratory Research |
| spelling | doaj.art-546e097d907c490c9815d6725b2f38fa2024-04-21T11:27:52ZengBMCRespiratory Research1465-993X2024-04-0125111110.1186/s12931-024-02773-7Systemic IL-26 correlates with improved asthma control in children sensitized to dog allergenMelissa A. Kovach0Ulrika Käck1Karlhans F Che2Bettina Brundin3Jon R. Konradsen4Anders Lindén5Unit for Lung and Airway Research, Institute of Environmental Medicine, Karolinska InstitutetDepartment of Clinical Science and Education, Södersjukhuset, Karolinska InstitutetUnit for Lung and Airway Research, Institute of Environmental Medicine, Karolinska InstitutetUnit for Lung and Airway Research, Institute of Environmental Medicine, Karolinska InstitutetDepartment of Medicine Solna Immunology and Allergy Unit, Karolinska Institutet and Karolinska University HospitalUnit for Lung and Airway Research, Institute of Environmental Medicine, Karolinska InstitutetAbstract Background Interleukin (IL)-26 is produced by T helper type 17 (Type 17) cells and exerts immunomodulatory plus antimicrobial effects. Previous studies show that local IL-26 concentrations in the airways are higher in patients with uncontrolled than in those with controlled asthma, and that this intriguing cytokine bears biomarker potential. Here, we determined how systemic IL-26 relates to allergen sensitization, asthma severity, and to IL-17 A in children. Methods Serum samples were obtained from children with (n = 60) and without (n = 17) sensitization to dog allergen, and IL-26 and IL-17 A protein concentrations were measured using ELISA. Self-reported history, including medication use and validated symptom-based questionnaire scores, was recorded. Results The serum concentrations of IL-26 were enhanced in allergen-sensitized subjects and correlated with those of IL-17 A in a positive manner. However, the IL-26 concentrations did not markedly differ between allergen-sensitized subjects with and without asthma, eczema, allergic rhinitis, or a history of food allergy. Notably, IL-26 concentrations correlated with increasing Asthma Control Test (ACT) scores in a positive manner and with inhaled corticosteroid in a negative manner, amongst sensitized subjects with asthma. Moreover, subjects with asthma requiring ≥ 1 course of oral corticosteroids in the preceding 12 months had decreased IL-26 concentrations. Conclusion This study forwards evidence that systemic IL-26, just like IL-17 A, is involved in allergen sensitization among children. The association of systemic IL-26 with improved asthma control is compatible with the cellular sources being recruited into the airways in severe asthma, which supports that this kinocidin bears potential as a biomarker and therapeutic target.https://doi.org/10.1186/s12931-024-02773-7 |
| spellingShingle | Melissa A. Kovach Ulrika Käck Karlhans F Che Bettina Brundin Jon R. Konradsen Anders Lindén Systemic IL-26 correlates with improved asthma control in children sensitized to dog allergen Respiratory Research |
| title | Systemic IL-26 correlates with improved asthma control in children sensitized to dog allergen |
| title_full | Systemic IL-26 correlates with improved asthma control in children sensitized to dog allergen |
| title_fullStr | Systemic IL-26 correlates with improved asthma control in children sensitized to dog allergen |
| title_full_unstemmed | Systemic IL-26 correlates with improved asthma control in children sensitized to dog allergen |
| title_short | Systemic IL-26 correlates with improved asthma control in children sensitized to dog allergen |
| title_sort | systemic il 26 correlates with improved asthma control in children sensitized to dog allergen |
| url | https://doi.org/10.1186/s12931-024-02773-7 |
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