Association of <i>ALDH2</i> Genotypes and Alcohol Intake with Dietary Patterns: The Bunkyo Health Study
Dietary habits are associated with various diseases and assessed by dietary patterns (DPs). Since the <i>ALDH2</i> genotype is correlated with alcohol and several food preferences, this genotype is probably associated with DPs. In this cross-sectional study of 1612 elderly adults, we inv...
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MDPI AG
2022-11-01
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| author | Mari Sugimoto Hiroki Tabata Hideyoshi Kaga Yuki Someya Saori Kakehi Abulaiti Abudurezake Hitoshi Naito Naoaki Ito Huicong Shi Hikaru Otsuka Futaba Umemura Yasuyo Yoshizawa Ryuzo Kawamori Hirotaka Watada Yoshifumi Tamura |
| author_facet | Mari Sugimoto Hiroki Tabata Hideyoshi Kaga Yuki Someya Saori Kakehi Abulaiti Abudurezake Hitoshi Naito Naoaki Ito Huicong Shi Hikaru Otsuka Futaba Umemura Yasuyo Yoshizawa Ryuzo Kawamori Hirotaka Watada Yoshifumi Tamura |
| author_sort | Mari Sugimoto |
| collection | DOAJ |
| description | Dietary habits are associated with various diseases and assessed by dietary patterns (DPs). Since the <i>ALDH2</i> genotype is correlated with alcohol and several food preferences, this genotype is probably associated with DPs. In this cross-sectional study of 1612 elderly adults, we investigated the effects of the <i>ALDH2</i> genotype on DPs and the mediating role of alcohol intake. We identified the <i>ALDH2</i> genotype and conducted a dietary history survey, then used principal component analysis to determine DPs for each gender. We performed multiple regression analysis to determine the independent contribution of the <i>ALDH2</i> genotype and alcohol intake to DP scores. We identified three DPs: the “Japanese side dish type” (DP1), the “Japanese dish with alcohol type” (DP2), and the “Western dish with alcohol type” (DP3). In men, the single nucleotide polymorphism <i>ALDH2</i> rs671 was significantly associated with all DP scores. When alcohol intake was added as a covariate, <i>ALDH2</i> rs671 was still significantly correlated with the DP2 score but not with the DP1 or DP3 score, and alcohol intake was significantly correlated with all DP scores. In women, <i>ALDH2</i> rs671 was significantly associated with the DP2 and DP3 scores; however, after adding alcohol intake as a covariate, these associations disappeared, and alcohol intake significantly correlated with all DP scores. In conclusion, the <i>ALDH2</i> genotype was associated with several DPs in elderly adults, but most associations were mediated by alcohol intake. |
| first_indexed | 2024-03-09T18:05:56Z |
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| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T18:05:56Z |
| publishDate | 2022-11-01 |
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| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-546e4ac787ac4239ad9f0a98b812dd8d2023-11-24T09:31:51ZengMDPI AGNutrients2072-66432022-11-011422483010.3390/nu14224830Association of <i>ALDH2</i> Genotypes and Alcohol Intake with Dietary Patterns: The Bunkyo Health StudyMari Sugimoto0Hiroki Tabata1Hideyoshi Kaga2Yuki Someya3Saori Kakehi4Abulaiti Abudurezake5Hitoshi Naito6Naoaki Ito7Huicong Shi8Hikaru Otsuka9Futaba Umemura10Yasuyo Yoshizawa11Ryuzo Kawamori12Hirotaka Watada13Yoshifumi Tamura14Department of Sports Medicine and Sportology, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, JapanSportology Center, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, JapanMetabolism and Endocrinology, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, JapanSportology Center, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, JapanDepartment of Sports Medicine and Sportology, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, JapanSportology Center, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, JapanMetabolism and Endocrinology, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, JapanMetabolism and Endocrinology, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, JapanDepartment of Sports Medicine and Sportology, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, JapanDepartment of Sports Medicine and Sportology, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, JapanDepartment of Sports Medicine and Sportology, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, JapanCenter for Healthy Life Expectancy, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, JapanDepartment of Sports Medicine and Sportology, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, JapanSportology Center, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, JapanDepartment of Sports Medicine and Sportology, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, JapanDietary habits are associated with various diseases and assessed by dietary patterns (DPs). Since the <i>ALDH2</i> genotype is correlated with alcohol and several food preferences, this genotype is probably associated with DPs. In this cross-sectional study of 1612 elderly adults, we investigated the effects of the <i>ALDH2</i> genotype on DPs and the mediating role of alcohol intake. We identified the <i>ALDH2</i> genotype and conducted a dietary history survey, then used principal component analysis to determine DPs for each gender. We performed multiple regression analysis to determine the independent contribution of the <i>ALDH2</i> genotype and alcohol intake to DP scores. We identified three DPs: the “Japanese side dish type” (DP1), the “Japanese dish with alcohol type” (DP2), and the “Western dish with alcohol type” (DP3). In men, the single nucleotide polymorphism <i>ALDH2</i> rs671 was significantly associated with all DP scores. When alcohol intake was added as a covariate, <i>ALDH2</i> rs671 was still significantly correlated with the DP2 score but not with the DP1 or DP3 score, and alcohol intake was significantly correlated with all DP scores. In women, <i>ALDH2</i> rs671 was significantly associated with the DP2 and DP3 scores; however, after adding alcohol intake as a covariate, these associations disappeared, and alcohol intake significantly correlated with all DP scores. In conclusion, the <i>ALDH2</i> genotype was associated with several DPs in elderly adults, but most associations were mediated by alcohol intake.https://www.mdpi.com/2072-6643/14/22/4830dietary patterns<i>ALDH2</i> genotypealcohol intake |
| spellingShingle | Mari Sugimoto Hiroki Tabata Hideyoshi Kaga Yuki Someya Saori Kakehi Abulaiti Abudurezake Hitoshi Naito Naoaki Ito Huicong Shi Hikaru Otsuka Futaba Umemura Yasuyo Yoshizawa Ryuzo Kawamori Hirotaka Watada Yoshifumi Tamura Association of <i>ALDH2</i> Genotypes and Alcohol Intake with Dietary Patterns: The Bunkyo Health Study Nutrients dietary patterns <i>ALDH2</i> genotype alcohol intake |
| title | Association of <i>ALDH2</i> Genotypes and Alcohol Intake with Dietary Patterns: The Bunkyo Health Study |
| title_full | Association of <i>ALDH2</i> Genotypes and Alcohol Intake with Dietary Patterns: The Bunkyo Health Study |
| title_fullStr | Association of <i>ALDH2</i> Genotypes and Alcohol Intake with Dietary Patterns: The Bunkyo Health Study |
| title_full_unstemmed | Association of <i>ALDH2</i> Genotypes and Alcohol Intake with Dietary Patterns: The Bunkyo Health Study |
| title_short | Association of <i>ALDH2</i> Genotypes and Alcohol Intake with Dietary Patterns: The Bunkyo Health Study |
| title_sort | association of i aldh2 i genotypes and alcohol intake with dietary patterns the bunkyo health study |
| topic | dietary patterns <i>ALDH2</i> genotype alcohol intake |
| url | https://www.mdpi.com/2072-6643/14/22/4830 |
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