Development of an LC-MS/MS Method for ARV-110, a PROTAC Molecule, and Applications to Pharmacokinetic Studies

Development of an LC-MS/MS Method for ARV-110, a PROTAC Molecule, and Applications to Pharmacokinetic Studies

ARV-110, a novel proteolysis-targeting chimera (PROTAC), has been reported to show satisfactory safety and tolerability for prostate cancer therapy in phase I clinical trials. However, there is a lack of bioanalytical assays for ARV-110 determination in biological samples. In this study, we develope...

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Bibliographic Details
Main Authors:	Thi-Thao-Linh Nguyen, Jin Woo Kim, Hae-In Choi, Han-Joo Maeng, Tae-Sung Koo
Format:	Article
Language:	English
Published:	MDPI AG 2022-03-01
Series:	Molecules
Subjects:	ARV-110 proteolysis-targeting chimera LC-MS/MS validation stability pharmacokinetics
Online Access:	https://www.mdpi.com/1420-3049/27/6/1977

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