Pharmacologic Inhibition of Histone Deacetylase 6 Prevents the Progression of Chlorhexidine Gluconate-Induced Peritoneal Fibrosis by Blockade of M2 Macrophage Polarization

Pharmacologic Inhibition of Histone Deacetylase 6 Prevents the Progression of Chlorhexidine Gluconate-Induced Peritoneal Fibrosis by Blockade of M2 Macrophage Polarization

Peritoneal fibrosis contributes to ultrafiltration failure in peritoneal dialysis (PD) patients and thus restricts the wide application of PD in clinic. Recently we have demonstrated that histone deacetylase 6 (HDAC6) is critically implicated in high glucose peritoneal dialysis fluid (HG-PDF) induce...

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Bibliographic Details
Main Authors: Yingfeng Shi, Jinqing Li, Hui Chen, Yan Hu, Lunxian Tang, Xun Zhou, Min Tao, Zexin Lv, Si Chen, Andong Qiu, Na Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Immunology
Subjects:
peritoneal dialysis
peritoneal fibrosis
histone deacetylase 6
macrophage polarization
tubastatin A
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.899140/full

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