The impact of oocyte death on mouse primordial follicle formation and ovarian reserve
Abstract Background Ovaries, the source of oocytes, maintain the numbers of primordial follicles, develop oocytes for fertilization and embryonic development. Although it is well known that about two‐thirds of oocytes are lost during the formation of primordial follicles through cyst fragmentation a...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Reproductive Medicine and Biology |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/rmb2.12489 |
| _version_ | 1797976003959586816 |
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| author | Ken Umeno Ayana Sasaki Naoko Kimura |
| author_facet | Ken Umeno Ayana Sasaki Naoko Kimura |
| author_sort | Ken Umeno |
| collection | DOAJ |
| description | Abstract Background Ovaries, the source of oocytes, maintain the numbers of primordial follicles, develop oocytes for fertilization and embryonic development. Although it is well known that about two‐thirds of oocytes are lost during the formation of primordial follicles through cyst fragmentation and the aggregation of oocytes within the cyst, the mechanism responsible for this remains unclear. Methods We provide an overview of cell death that is associated with the oocyte cyst breakdown and primordial follicle assembly along with our recent findings for mice that had been treated with a TNFα ligand inhibitor. Main Findings It is generally accepted that apoptosis is the major mechanism responsible for the depletion of germ cells. In fact, a gene deficiency or the overexpression of apoptosis regulators can have a great effect on follicle numbers and/or fertility. Apoptosis, however, may not be the only cause of the large‐scale oocyte attrition during oocyte cyst breakdown, and other mechanisms, such as aggregation, may also be involved in this process. Conclusion The continued study of oocyte death during primordial follicle formation could lead to the development of novel strategies for manipulating the primordial follicle pool, leading to improved fertility by enhancing the ovarian reserve. |
| first_indexed | 2024-04-11T04:44:24Z |
| format | Article |
| id | doaj.art-5470d923ec164641a7598527f51ec1f5 |
| institution | Directory Open Access Journal |
| issn | 1445-5781 1447-0578 |
| language | English |
| last_indexed | 2024-04-11T04:44:24Z |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Reproductive Medicine and Biology |
| spelling | doaj.art-5470d923ec164641a7598527f51ec1f52022-12-27T13:54:57ZengWileyReproductive Medicine and Biology1445-57811447-05782022-01-01211n/an/a10.1002/rmb2.12489The impact of oocyte death on mouse primordial follicle formation and ovarian reserveKen Umeno0Ayana Sasaki1Naoko Kimura2Laboratory of Animal Reproduction, Graduate School of Agricultural Science Yamagata University Tsuruoka JapanLaboratory of Animal Reproduction, Graduate School of Agricultural Science Yamagata University Tsuruoka JapanLaboratory of Animal Reproduction, Graduate School of Agricultural Science Yamagata University Tsuruoka JapanAbstract Background Ovaries, the source of oocytes, maintain the numbers of primordial follicles, develop oocytes for fertilization and embryonic development. Although it is well known that about two‐thirds of oocytes are lost during the formation of primordial follicles through cyst fragmentation and the aggregation of oocytes within the cyst, the mechanism responsible for this remains unclear. Methods We provide an overview of cell death that is associated with the oocyte cyst breakdown and primordial follicle assembly along with our recent findings for mice that had been treated with a TNFα ligand inhibitor. Main Findings It is generally accepted that apoptosis is the major mechanism responsible for the depletion of germ cells. In fact, a gene deficiency or the overexpression of apoptosis regulators can have a great effect on follicle numbers and/or fertility. Apoptosis, however, may not be the only cause of the large‐scale oocyte attrition during oocyte cyst breakdown, and other mechanisms, such as aggregation, may also be involved in this process. Conclusion The continued study of oocyte death during primordial follicle formation could lead to the development of novel strategies for manipulating the primordial follicle pool, leading to improved fertility by enhancing the ovarian reserve.https://doi.org/10.1002/rmb2.12489apoptosiscell deathfertilityovarian reserveprimordial follicle formation |
| spellingShingle | Ken Umeno Ayana Sasaki Naoko Kimura The impact of oocyte death on mouse primordial follicle formation and ovarian reserve Reproductive Medicine and Biology apoptosis cell death fertility ovarian reserve primordial follicle formation |
| title | The impact of oocyte death on mouse primordial follicle formation and ovarian reserve |
| title_full | The impact of oocyte death on mouse primordial follicle formation and ovarian reserve |
| title_fullStr | The impact of oocyte death on mouse primordial follicle formation and ovarian reserve |
| title_full_unstemmed | The impact of oocyte death on mouse primordial follicle formation and ovarian reserve |
| title_short | The impact of oocyte death on mouse primordial follicle formation and ovarian reserve |
| title_sort | impact of oocyte death on mouse primordial follicle formation and ovarian reserve |
| topic | apoptosis cell death fertility ovarian reserve primordial follicle formation |
| url | https://doi.org/10.1002/rmb2.12489 |
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