Kinase Inhibitors in Genetic Diseases
Over the years, several studies have shown that kinase-regulated signaling pathways are involved in the development of rare genetic diseases. The study of the mechanisms underlying the onset of these diseases has opened a possible way for the development of targeted therapies using particular kinase...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-03-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/6/5276 |
| _version_ | 1797611302077595648 |
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| author | Lucia D’Antona Rosario Amato Carolina Brescia Valentina Rocca Emma Colao Rodolfo Iuliano Bonnie L. Blazer-Yost Nicola Perrotti |
| author_facet | Lucia D’Antona Rosario Amato Carolina Brescia Valentina Rocca Emma Colao Rodolfo Iuliano Bonnie L. Blazer-Yost Nicola Perrotti |
| author_sort | Lucia D’Antona |
| collection | DOAJ |
| description | Over the years, several studies have shown that kinase-regulated signaling pathways are involved in the development of rare genetic diseases. The study of the mechanisms underlying the onset of these diseases has opened a possible way for the development of targeted therapies using particular kinase inhibitors. Some of these are currently used to treat other diseases, such as cancer. This review aims to describe the possibilities of using kinase inhibitors in genetic pathologies such as tuberous sclerosis, RASopathies, and ciliopathies, describing the various pathways involved and the possible targets already identified or currently under study. |
| first_indexed | 2024-03-11T06:26:59Z |
| format | Article |
| id | doaj.art-547350cd22ef4cb7b51f6e6421573025 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T06:26:59Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-547350cd22ef4cb7b51f6e64215730252023-11-17T11:31:35ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-03-01246527610.3390/ijms24065276Kinase Inhibitors in Genetic DiseasesLucia D’Antona0Rosario Amato1Carolina Brescia2Valentina Rocca3Emma Colao4Rodolfo Iuliano5Bonnie L. Blazer-Yost6Nicola Perrotti7Department of Health Sciences, University “Magna Graecia” at Catanzaro, 88100 Catanzaro, ItalyDepartment of Health Sciences, University “Magna Graecia” at Catanzaro, 88100 Catanzaro, ItalyDepartment of Health Sciences, University “Magna Graecia” at Catanzaro, 88100 Catanzaro, ItalyMedical Genetics Unit, University Hospital “Mater Domini” at Catanzaro, 88100 Catanzaro, ItalyMedical Genetics Unit, University Hospital “Mater Domini” at Catanzaro, 88100 Catanzaro, ItalyDepartment of Health Sciences, University “Magna Graecia” at Catanzaro, 88100 Catanzaro, ItalyDepartment of Biology, Indiana University Purdue University, Indianapolis, IN 46202, USADepartment of Health Sciences, University “Magna Graecia” at Catanzaro, 88100 Catanzaro, ItalyOver the years, several studies have shown that kinase-regulated signaling pathways are involved in the development of rare genetic diseases. The study of the mechanisms underlying the onset of these diseases has opened a possible way for the development of targeted therapies using particular kinase inhibitors. Some of these are currently used to treat other diseases, such as cancer. This review aims to describe the possibilities of using kinase inhibitors in genetic pathologies such as tuberous sclerosis, RASopathies, and ciliopathies, describing the various pathways involved and the possible targets already identified or currently under study.https://www.mdpi.com/1422-0067/24/6/5276kinase inhibitorsgeneticsRAS pathwaymTOR pathwayWnt pathway |
| spellingShingle | Lucia D’Antona Rosario Amato Carolina Brescia Valentina Rocca Emma Colao Rodolfo Iuliano Bonnie L. Blazer-Yost Nicola Perrotti Kinase Inhibitors in Genetic Diseases International Journal of Molecular Sciences kinase inhibitors genetics RAS pathway mTOR pathway Wnt pathway |
| title | Kinase Inhibitors in Genetic Diseases |
| title_full | Kinase Inhibitors in Genetic Diseases |
| title_fullStr | Kinase Inhibitors in Genetic Diseases |
| title_full_unstemmed | Kinase Inhibitors in Genetic Diseases |
| title_short | Kinase Inhibitors in Genetic Diseases |
| title_sort | kinase inhibitors in genetic diseases |
| topic | kinase inhibitors genetics RAS pathway mTOR pathway Wnt pathway |
| url | https://www.mdpi.com/1422-0067/24/6/5276 |
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