Clinical Applications of Liquid Biopsy in Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is a common malignant tumor with high mortality and poor prognosis in the world. The low rate of early diagnosis, as well as the high risk of postoperative metastasis and recurrence, led to the poor clinical prognosis of HCC patients. Currently, it mainly depends on se...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-02-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.781820/full |
| _version_ | 1819284522310565888 |
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| author | Jin-Cui Yang Jun-Jie Hu Yi-Xin Li Wei Luo Jin-Zhou Liu Da-Wei Ye Da-Wei Ye |
| author_facet | Jin-Cui Yang Jun-Jie Hu Yi-Xin Li Wei Luo Jin-Zhou Liu Da-Wei Ye Da-Wei Ye |
| author_sort | Jin-Cui Yang |
| collection | DOAJ |
| description | Hepatocellular carcinoma (HCC) is a common malignant tumor with high mortality and poor prognosis in the world. The low rate of early diagnosis, as well as the high risk of postoperative metastasis and recurrence, led to the poor clinical prognosis of HCC patients. Currently, it mainly depends on serum markers, imaging examination, and tissue biopsy to diagnose and determine the recurrence and metastasis of HCC after treatments. Nevertheless, the accuracy and sensitivity of serum markers and imaging for early HCC diagnosis are suboptimal. Tissue biopsy, containing limited tissue samples, is insufficient to reveal comprehensive tumor biology information and is inappropriate to monitor dynamic tumor progression due to its invasiveness. Thus, low invasive diagnostic methods and novel biomarkers with high sensitivity and reliability must be found to improve HCC detection and prediction. As a non-invasive, dynamic, and repeatable detection method, “liquid biopsy”, has attracted much attention to early diagnosis and monitoring of treatment response, which promotes the progress of precision medicine. This review summarizes the clinical applications of liquid biopsy in HCC, including circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), and exosome in early diagnosis, prognostic evaluation, disease monitoring, and guiding personalized treatment. |
| first_indexed | 2024-12-24T01:48:43Z |
| format | Article |
| id | doaj.art-547403cb2b3b45bda6fa090e76fa6ce3 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-24T01:48:43Z |
| publishDate | 2022-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-547403cb2b3b45bda6fa090e76fa6ce32022-12-21T17:21:47ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-02-011210.3389/fonc.2022.781820781820Clinical Applications of Liquid Biopsy in Hepatocellular CarcinomaJin-Cui Yang0Jun-Jie Hu1Yi-Xin Li2Wei Luo3Jin-Zhou Liu4Da-Wei Ye5Da-Wei Ye6Cancer Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaCancer Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaCancer Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaCancer Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Pain Management, The Second Affiliated Hospital of Guangxi Medical University, Nanning, ChinaCancer Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Pancreatic-Biliary Surgery, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, ChinaHepatocellular carcinoma (HCC) is a common malignant tumor with high mortality and poor prognosis in the world. The low rate of early diagnosis, as well as the high risk of postoperative metastasis and recurrence, led to the poor clinical prognosis of HCC patients. Currently, it mainly depends on serum markers, imaging examination, and tissue biopsy to diagnose and determine the recurrence and metastasis of HCC after treatments. Nevertheless, the accuracy and sensitivity of serum markers and imaging for early HCC diagnosis are suboptimal. Tissue biopsy, containing limited tissue samples, is insufficient to reveal comprehensive tumor biology information and is inappropriate to monitor dynamic tumor progression due to its invasiveness. Thus, low invasive diagnostic methods and novel biomarkers with high sensitivity and reliability must be found to improve HCC detection and prediction. As a non-invasive, dynamic, and repeatable detection method, “liquid biopsy”, has attracted much attention to early diagnosis and monitoring of treatment response, which promotes the progress of precision medicine. This review summarizes the clinical applications of liquid biopsy in HCC, including circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), and exosome in early diagnosis, prognostic evaluation, disease monitoring, and guiding personalized treatment.https://www.frontiersin.org/articles/10.3389/fonc.2022.781820/fullclinical applicationliquid biopsycirculating tumor cellscirculating tumor DNAexosomehepatocellular carcinoma |
| spellingShingle | Jin-Cui Yang Jun-Jie Hu Yi-Xin Li Wei Luo Jin-Zhou Liu Da-Wei Ye Da-Wei Ye Clinical Applications of Liquid Biopsy in Hepatocellular Carcinoma Frontiers in Oncology clinical application liquid biopsy circulating tumor cells circulating tumor DNA exosome hepatocellular carcinoma |
| title | Clinical Applications of Liquid Biopsy in Hepatocellular Carcinoma |
| title_full | Clinical Applications of Liquid Biopsy in Hepatocellular Carcinoma |
| title_fullStr | Clinical Applications of Liquid Biopsy in Hepatocellular Carcinoma |
| title_full_unstemmed | Clinical Applications of Liquid Biopsy in Hepatocellular Carcinoma |
| title_short | Clinical Applications of Liquid Biopsy in Hepatocellular Carcinoma |
| title_sort | clinical applications of liquid biopsy in hepatocellular carcinoma |
| topic | clinical application liquid biopsy circulating tumor cells circulating tumor DNA exosome hepatocellular carcinoma |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.781820/full |
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