Behavior of Eosinophil Counts in Recovered and Deceased COVID-19 Patients over the Course of the Disease
Knowledge about the immune responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, particularly regarding the function of eosinophils, has been steadily emerging recently. There exists controversy regarding the implications of eosinophils in the coronavirus disease...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/13/9/1675 |
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| author | Ricarda Cortés-Vieyra Sergio Gutiérrez-Castellanos Cleto Álvarez-Aguilar Víctor Manuel Baizabal-Aguirre Rosa Elvira Nuñez-Anita Angélica Georgina Rocha-López Anel Gómez-García |
| author_facet | Ricarda Cortés-Vieyra Sergio Gutiérrez-Castellanos Cleto Álvarez-Aguilar Víctor Manuel Baizabal-Aguirre Rosa Elvira Nuñez-Anita Angélica Georgina Rocha-López Anel Gómez-García |
| author_sort | Ricarda Cortés-Vieyra |
| collection | DOAJ |
| description | Knowledge about the immune responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, particularly regarding the function of eosinophils, has been steadily emerging recently. There exists controversy regarding the implications of eosinophils in the coronavirus disease 2019 (COVID-19)’s pathology. We report a retrospective cohort study including the comparison of leukocyte counts in COVID-19 patients, considering the outcomes of recovery (<i>n</i> = 59) and death (<i>n</i> = 60). Among the different types of leukocytes, the eosinophil counts were those that showed the greatest difference between recovered and deceased patients. Eosinopenia (eosinophil count < 0.01 × 10<sup>9</sup>/L) was more frequently observed in deceased than recovered patients (<i>p</i> = 0.0012). The eosinophil counts more rapidly increased and showed a greater proportion over the course of the disease in the recovered than deceased patients. Furthermore, the estimated survival rate was greater in patients without eosinopenia than in patients with eosinopenia (<i>p</i> = 0.0070) during hospitalization. Importantly, recovered but not deceased patients showed high negative correlations of the eosinophils with the neutrophil-to-lymphocyte ratio (NLR) and neutrophil counts at Day 9 of the onset of clinical symptoms (<i>p</i> ≤ 0.0220). Our analysis suggests that eosinopenia may be associated with unfavorable disease outcomes and that the eosinophils have a beneficial function in COVID-19 patients, probably contributing by controlling the exacerbated inflammation induced by neutrophils. |
| first_indexed | 2024-03-10T07:08:35Z |
| format | Article |
| id | doaj.art-5474a61138b34cc5a6f5f88a98bf7efa |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T07:08:35Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-5474a61138b34cc5a6f5f88a98bf7efa2023-11-22T15:36:16ZengMDPI AGViruses1999-49152021-08-01139167510.3390/v13091675Behavior of Eosinophil Counts in Recovered and Deceased COVID-19 Patients over the Course of the DiseaseRicarda Cortés-Vieyra0Sergio Gutiérrez-Castellanos1Cleto Álvarez-Aguilar2Víctor Manuel Baizabal-Aguirre3Rosa Elvira Nuñez-Anita4Angélica Georgina Rocha-López5Anel Gómez-García6Centro de Investigación Biomédica de Michoacán, División de Investigación Clínica, Instituto Mexicano del Seguro Social (IMSS), Morelia 58341, Michoacán, MexicoCentro de Investigación Biomédica de Michoacán, División de Investigación Clínica, Instituto Mexicano del Seguro Social (IMSS), Morelia 58341, Michoacán, MexicoDivisión de Estudios de Posgrado, Facultad de Ciencias Médicas y Biológicas “Dr. Ignacio Chávez”, Universidad Michoacana de San Nicolás de Hidalgo (UMSNH), Morelia 58020, Michoacán, MexicoCentro Multidisciplinario de Estudios en Biotecnología, Facultad de Medicina Veterinaria y Zootecnia, UMSNH, Morelia 58890, Michoacán, MexicoCentro Multidisciplinario de Estudios en Biotecnología, Facultad de Medicina Veterinaria y Zootecnia, UMSNH, Morelia 58890, Michoacán, MexicoDivisión de Estudios de Posgrado, Facultad de Ciencias Médicas y Biológicas “Dr. Ignacio Chávez”, Universidad Michoacana de San Nicolás de Hidalgo (UMSNH), Morelia 58020, Michoacán, MexicoCentro de Investigación Biomédica de Michoacán, División de Investigación Clínica, Instituto Mexicano del Seguro Social (IMSS), Morelia 58341, Michoacán, MexicoKnowledge about the immune responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, particularly regarding the function of eosinophils, has been steadily emerging recently. There exists controversy regarding the implications of eosinophils in the coronavirus disease 2019 (COVID-19)’s pathology. We report a retrospective cohort study including the comparison of leukocyte counts in COVID-19 patients, considering the outcomes of recovery (<i>n</i> = 59) and death (<i>n</i> = 60). Among the different types of leukocytes, the eosinophil counts were those that showed the greatest difference between recovered and deceased patients. Eosinopenia (eosinophil count < 0.01 × 10<sup>9</sup>/L) was more frequently observed in deceased than recovered patients (<i>p</i> = 0.0012). The eosinophil counts more rapidly increased and showed a greater proportion over the course of the disease in the recovered than deceased patients. Furthermore, the estimated survival rate was greater in patients without eosinopenia than in patients with eosinopenia (<i>p</i> = 0.0070) during hospitalization. Importantly, recovered but not deceased patients showed high negative correlations of the eosinophils with the neutrophil-to-lymphocyte ratio (NLR) and neutrophil counts at Day 9 of the onset of clinical symptoms (<i>p</i> ≤ 0.0220). Our analysis suggests that eosinopenia may be associated with unfavorable disease outcomes and that the eosinophils have a beneficial function in COVID-19 patients, probably contributing by controlling the exacerbated inflammation induced by neutrophils.https://www.mdpi.com/1999-4915/13/9/1675eosinophilsneutrophilswhite blood cell differential countsneutrophil-to-lymphocyte ratioCOVID-19 |
| spellingShingle | Ricarda Cortés-Vieyra Sergio Gutiérrez-Castellanos Cleto Álvarez-Aguilar Víctor Manuel Baizabal-Aguirre Rosa Elvira Nuñez-Anita Angélica Georgina Rocha-López Anel Gómez-García Behavior of Eosinophil Counts in Recovered and Deceased COVID-19 Patients over the Course of the Disease Viruses eosinophils neutrophils white blood cell differential counts neutrophil-to-lymphocyte ratio COVID-19 |
| title | Behavior of Eosinophil Counts in Recovered and Deceased COVID-19 Patients over the Course of the Disease |
| title_full | Behavior of Eosinophil Counts in Recovered and Deceased COVID-19 Patients over the Course of the Disease |
| title_fullStr | Behavior of Eosinophil Counts in Recovered and Deceased COVID-19 Patients over the Course of the Disease |
| title_full_unstemmed | Behavior of Eosinophil Counts in Recovered and Deceased COVID-19 Patients over the Course of the Disease |
| title_short | Behavior of Eosinophil Counts in Recovered and Deceased COVID-19 Patients over the Course of the Disease |
| title_sort | behavior of eosinophil counts in recovered and deceased covid 19 patients over the course of the disease |
| topic | eosinophils neutrophils white blood cell differential counts neutrophil-to-lymphocyte ratio COVID-19 |
| url | https://www.mdpi.com/1999-4915/13/9/1675 |
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