Nuclear Localization of p38 MAPK in Response to DNA Damage
<p>p38 MAP kinase (MAPK) is activated in response to environmental stress, cytokines and DNA damage, and mediates death, cell differentiation and cell cycle checkpoints. The intracellular localization of p38 MAPK upon activation remains unclear, and may depend on the stimulus. We show here tha...
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| Format: | Article |
| Language: | English |
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Ivyspring International Publisher
2009-01-01
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| Series: | International Journal of Biological Sciences |
| Online Access: | http://www.biolsci.org/v05p0428.htm |
| _version_ | 1828879648193249280 |
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| author | C. David Wood, Tina M. Thornton, Guadalupe Sabio, Roger A. Davis, Mercedes Rincon |
| author_facet | C. David Wood, Tina M. Thornton, Guadalupe Sabio, Roger A. Davis, Mercedes Rincon |
| author_sort | C. David Wood, Tina M. Thornton, Guadalupe Sabio, Roger A. Davis, Mercedes Rincon |
| collection | DOAJ |
| description | <p>p38 MAP kinase (MAPK) is activated in response to environmental stress, cytokines and DNA damage, and mediates death, cell differentiation and cell cycle checkpoints. The intracellular localization of p38 MAPK upon activation remains unclear, and may depend on the stimulus. We show here that activation of p38 MAPK by stimuli that induce DNA double strand breaks (DSBs), but not other stimuli, leads to its nuclear translocation. In addition, naturally occurring DSBs generated through V(D)J recombination in immature thymocytes also promote nuclear accumulation of p38 MAPK. Nuclear translocation of p38 MAPK does not require its catalytic activity, but is induced by a conformational change of p38 MAPK triggered by phosphorylation within the active site. The selective nuclear accumulation of p38 MAPK in response to DNA damage could be a mechanism to facilitate the phosphorylation of p38 MAPK nuclear targets for the induction of a G2/M cell cycle checkpoint and DNA repair.</p> |
| first_indexed | 2024-12-13T09:31:25Z |
| format | Article |
| id | doaj.art-547a81a4416045e4a218f05223a7af37 |
| institution | Directory Open Access Journal |
| issn | 1449-2288 |
| language | English |
| last_indexed | 2024-12-13T09:31:25Z |
| publishDate | 2009-01-01 |
| publisher | Ivyspring International Publisher |
| record_format | Article |
| series | International Journal of Biological Sciences |
| spelling | doaj.art-547a81a4416045e4a218f05223a7af372022-12-21T23:52:28ZengIvyspring International PublisherInternational Journal of Biological Sciences1449-22882009-01-0155428437Nuclear Localization of p38 MAPK in Response to DNA DamageC. David Wood, Tina M. Thornton, Guadalupe Sabio, Roger A. Davis, Mercedes Rincon<p>p38 MAP kinase (MAPK) is activated in response to environmental stress, cytokines and DNA damage, and mediates death, cell differentiation and cell cycle checkpoints. The intracellular localization of p38 MAPK upon activation remains unclear, and may depend on the stimulus. We show here that activation of p38 MAPK by stimuli that induce DNA double strand breaks (DSBs), but not other stimuli, leads to its nuclear translocation. In addition, naturally occurring DSBs generated through V(D)J recombination in immature thymocytes also promote nuclear accumulation of p38 MAPK. Nuclear translocation of p38 MAPK does not require its catalytic activity, but is induced by a conformational change of p38 MAPK triggered by phosphorylation within the active site. The selective nuclear accumulation of p38 MAPK in response to DNA damage could be a mechanism to facilitate the phosphorylation of p38 MAPK nuclear targets for the induction of a G2/M cell cycle checkpoint and DNA repair.</p>http://www.biolsci.org/v05p0428.htm |
| spellingShingle | C. David Wood, Tina M. Thornton, Guadalupe Sabio, Roger A. Davis, Mercedes Rincon Nuclear Localization of p38 MAPK in Response to DNA Damage International Journal of Biological Sciences |
| title | Nuclear Localization of p38 MAPK in Response to DNA Damage |
| title_full | Nuclear Localization of p38 MAPK in Response to DNA Damage |
| title_fullStr | Nuclear Localization of p38 MAPK in Response to DNA Damage |
| title_full_unstemmed | Nuclear Localization of p38 MAPK in Response to DNA Damage |
| title_short | Nuclear Localization of p38 MAPK in Response to DNA Damage |
| title_sort | nuclear localization of p38 mapk in response to dna damage |
| url | http://www.biolsci.org/v05p0428.htm |
| work_keys_str_mv | AT cdavidwoodtinamthorntonguadalupesabiorogeradavismercedesrincon nuclearlocalizationofp38mapkinresponsetodnadamage |