Spontaneous Suppressors against Debilitating Transmembrane Mutants of <i>Ca</i>Mdr1 Disclose Novel Interdomain Communication via Signature Motifs of the Major Facilitator Superfamily
The Major Facilitator Superfamily (MFS) drug:H<sup>+</sup> antiporter <i>Ca</i>Mdr1, from <i>Candida albicans</i>, is responsible for the efflux of structurally diverse antifungals. MFS members share a common fold of 12–14 transmembrane helices (TMHs) forming two...
Main Authors: | , , , , , |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2022-05-01
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Series: | Journal of Fungi |
Subjects: | |
Online Access: | https://www.mdpi.com/2309-608X/8/5/538 |