Synthesis, Characterization, DNA Binding and Nuclease Activity of Cobalt(II) Complexes of Isonicotinoyl Hydrazones
Cobalt(II) complexes of isonicotinoyl hydrazones of two series of ligands have been synthesized and characterized on the basis of elemental analyses, molar conductance, magnetic moment, mass, IR, UV spectral data. Electrochemical behavior of ligands and complexes has been investigated by using cycl...
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| Format: | Article |
| Language: | English |
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Iranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECR
2018-08-01
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| Series: | Iranian Journal of Chemistry & Chemical Engineering |
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| Online Access: | http://www.ijcce.ac.ir/article_33156_ad175e28b544a7b08bf092860daf3636.pdf |
| _version_ | 1818054978608037888 |
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| author | Akkili Suselamma karredduala Raja Katreddi Hussain Reddy |
| author_facet | Akkili Suselamma karredduala Raja Katreddi Hussain Reddy |
| author_sort | Akkili Suselamma |
| collection | DOAJ |
| description | Cobalt(II) complexes of isonicotinoyl hydrazones of two series of ligands have been synthesized and characterized on the basis of elemental analyses, molar conductance, magnetic moment, mass, IR, UV spectral data. Electrochemical behavior of ligands and complexes has been investigated by using cyclic voltammetry. Cyclic voltammetric studies reveal that the oxidation/reduction potentials of all complexes are shifted towards positive or negative values than its corresponding ligands. The interactions of these complexes with calf thymus DNA have been studied by using absorption studies. Bathochromic shift and hypochromism suggest that the intercalative mode of binding of complexes with DNA. Their DNA cleavage activity of complexes was studied on double-stranded pBR322 plasmid DNA using gel electrophoresis experiments in the absence and presence of oxidant (H2O2) and reductant (DTT). |
| first_indexed | 2024-12-10T12:05:38Z |
| format | Article |
| id | doaj.art-5480aeebdd3c4df38218e4964c0c4d71 |
| institution | Directory Open Access Journal |
| issn | 1021-9986 1021-9986 |
| language | English |
| last_indexed | 2024-12-10T12:05:38Z |
| publishDate | 2018-08-01 |
| publisher | Iranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECR |
| record_format | Article |
| series | Iranian Journal of Chemistry & Chemical Engineering |
| spelling | doaj.art-5480aeebdd3c4df38218e4964c0c4d712022-12-22T01:49:28ZengIranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECRIranian Journal of Chemistry & Chemical Engineering1021-99861021-99862018-08-01374637433156Synthesis, Characterization, DNA Binding and Nuclease Activity of Cobalt(II) Complexes of Isonicotinoyl HydrazonesAkkili Suselamma0karredduala Raja1Katreddi Hussain Reddy2Department of Chemistry, Hindu P.G.College for Women, Sananth Nagar, Hyderabad-500038, INDIADepartment of Chemistry, Rajeev Gandhi Memorial College of Engineering and Technology (Autonomous), Nandyal, Kurnool District, Andhara Pradesh State. INDIADepartment of Chemistry, Sri Krishnadevaraya University, Anantapuramu-515003, INDIACobalt(II) complexes of isonicotinoyl hydrazones of two series of ligands have been synthesized and characterized on the basis of elemental analyses, molar conductance, magnetic moment, mass, IR, UV spectral data. Electrochemical behavior of ligands and complexes has been investigated by using cyclic voltammetry. Cyclic voltammetric studies reveal that the oxidation/reduction potentials of all complexes are shifted towards positive or negative values than its corresponding ligands. The interactions of these complexes with calf thymus DNA have been studied by using absorption studies. Bathochromic shift and hypochromism suggest that the intercalative mode of binding of complexes with DNA. Their DNA cleavage activity of complexes was studied on double-stranded pBR322 plasmid DNA using gel electrophoresis experiments in the absence and presence of oxidant (H2O2) and reductant (DTT).http://www.ijcce.ac.ir/article_33156_ad175e28b544a7b08bf092860daf3636.pdfco(ii) complexesisonicotinoyl hydrazonescyclic voltammetrydna binding, dna cleavage |
| spellingShingle | Akkili Suselamma karredduala Raja Katreddi Hussain Reddy Synthesis, Characterization, DNA Binding and Nuclease Activity of Cobalt(II) Complexes of Isonicotinoyl Hydrazones Iranian Journal of Chemistry & Chemical Engineering co(ii) complexes isonicotinoyl hydrazones cyclic voltammetry dna binding, dna cleavage |
| title | Synthesis, Characterization, DNA Binding and Nuclease Activity of Cobalt(II) Complexes of Isonicotinoyl Hydrazones |
| title_full | Synthesis, Characterization, DNA Binding and Nuclease Activity of Cobalt(II) Complexes of Isonicotinoyl Hydrazones |
| title_fullStr | Synthesis, Characterization, DNA Binding and Nuclease Activity of Cobalt(II) Complexes of Isonicotinoyl Hydrazones |
| title_full_unstemmed | Synthesis, Characterization, DNA Binding and Nuclease Activity of Cobalt(II) Complexes of Isonicotinoyl Hydrazones |
| title_short | Synthesis, Characterization, DNA Binding and Nuclease Activity of Cobalt(II) Complexes of Isonicotinoyl Hydrazones |
| title_sort | synthesis characterization dna binding and nuclease activity of cobalt ii complexes of isonicotinoyl hydrazones |
| topic | co(ii) complexes isonicotinoyl hydrazones cyclic voltammetry dna binding, dna cleavage |
| url | http://www.ijcce.ac.ir/article_33156_ad175e28b544a7b08bf092860daf3636.pdf |
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