FEATURES OF CYTOKINE PRODUCTION DURING REHABILITATION AFTER COVID-19 IN PEOPLE LIVING IN THE NORTHERN REGIONS OF SIBERIA
The coronavirus infection of 2019 (COVID-19) has significantly affected the modern world. Recently, it has been proven that IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IFN-γ and TNF-α play an important role in the inflammatory response of the body to SARS-CoV-2 infection. Purpose. To study the features...
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| Format: | Article |
| Language: | English |
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Science and Innovation Center Publishing House
2023-12-01
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| Series: | Siberian Journal of Life Sciences and Agriculture |
| Subjects: | |
| Online Access: | http://discover-journal.ru/jour/index.php/sjlsa/article/view/967 |
| _version_ | 1797246100898316288 |
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| author | Vasilii D. Belenyuk Alexander A. Sinyakov Ekaterina O. Shavrina Olga L. Moskalenko |
| author_facet | Vasilii D. Belenyuk Alexander A. Sinyakov Ekaterina O. Shavrina Olga L. Moskalenko |
| author_sort | Vasilii D. Belenyuk |
| collection | DOAJ |
| description | The coronavirus infection of 2019 (COVID-19) has significantly affected the modern world. Recently, it has been proven that IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IFN-γ and TNF-α play an important role in the inflammatory response of the body to SARS-CoV-2 infection.
Purpose. To study the features of the synthesis of key cytokines in residents of the Turukhansky district of the Krasnoyarsk Territory who underwent COVID-19.
Materials and methods. On the basis of "Turukhanskaya RB", village. Turukhansk, in February 2023, 98 patients were examined, the average age was 58 (± 5 years). Of the 98 participants interviewed, 76 people had an official diagnosis of COVID-19 in the period from October 2020. The study was conducted with the permission of the ethical committee of the Research Institute of Medical Problems of the North. Each participant signed an informed consent form for the examination, according to the Helsinki Declaration of the World Medical Association regulating the conduct of scientific research.
Results. A high IgG titer to SARS-Cov-2 was observed in 99% of the examined, a positive IdM titer to SARS-Cov-2 was in 1% of the examined. In the course of studying the features of the cytokine network in patients with Turukhansk there was a significant decrease in the concentration of α-TNF, IL-1b and IL-10, as well as an increase in IL-2, IL-6 and IL-8 relative to the control group of Krasnoyarsk. α-IFN and IL-4 showed no significant changes and remained within the control range. At the same time, no differences were found between the groups of patients with a confirmed diagnosis of COVID-19 and without it.
Conclusion. The data obtained indicate a high level of homogeneity of the sample in the village . Turukhansk, regardless of the presence of the disease, about the low level of detection and control over the course of COVID-19. We observe the formation of a chronic inflammatory process against the background of the prevalence of pro-inflammatory function and an increase in the concentration of pro-inflammatory cytokines, which can subsequently deplete the body's resources and contribute to the development of additional complications. |
| first_indexed | 2024-04-24T19:37:26Z |
| format | Article |
| id | doaj.art-548186ccf5ba4b6188e8d2d61a416dda |
| institution | Directory Open Access Journal |
| issn | 2658-6649 2658-6657 |
| language | English |
| last_indexed | 2024-04-24T19:37:26Z |
| publishDate | 2023-12-01 |
| publisher | Science and Innovation Center Publishing House |
| record_format | Article |
| series | Siberian Journal of Life Sciences and Agriculture |
| spelling | doaj.art-548186ccf5ba4b6188e8d2d61a416dda2024-03-25T12:14:59ZengScience and Innovation Center Publishing HouseSiberian Journal of Life Sciences and Agriculture2658-66492658-66572023-12-0115634335910.12731/2658-6649-2023-15-6-967967FEATURES OF CYTOKINE PRODUCTION DURING REHABILITATION AFTER COVID-19 IN PEOPLE LIVING IN THE NORTHERN REGIONS OF SIBERIAVasilii D. Belenyuk0Alexander A. Sinyakov1Ekaterina O. Shavrina2Olga L. Moskalenko3Scientific Research Institute of Medical Problems of the NorthScientific Research Institute of Medical Problems of the NorthScientific Research Institute of Medical Problems of the NorthScientific Research Institute of Medical Problems of the NorthThe coronavirus infection of 2019 (COVID-19) has significantly affected the modern world. Recently, it has been proven that IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IFN-γ and TNF-α play an important role in the inflammatory response of the body to SARS-CoV-2 infection. Purpose. To study the features of the synthesis of key cytokines in residents of the Turukhansky district of the Krasnoyarsk Territory who underwent COVID-19. Materials and methods. On the basis of "Turukhanskaya RB", village. Turukhansk, in February 2023, 98 patients were examined, the average age was 58 (± 5 years). Of the 98 participants interviewed, 76 people had an official diagnosis of COVID-19 in the period from October 2020. The study was conducted with the permission of the ethical committee of the Research Institute of Medical Problems of the North. Each participant signed an informed consent form for the examination, according to the Helsinki Declaration of the World Medical Association regulating the conduct of scientific research. Results. A high IgG titer to SARS-Cov-2 was observed in 99% of the examined, a positive IdM titer to SARS-Cov-2 was in 1% of the examined. In the course of studying the features of the cytokine network in patients with Turukhansk there was a significant decrease in the concentration of α-TNF, IL-1b and IL-10, as well as an increase in IL-2, IL-6 and IL-8 relative to the control group of Krasnoyarsk. α-IFN and IL-4 showed no significant changes and remained within the control range. At the same time, no differences were found between the groups of patients with a confirmed diagnosis of COVID-19 and without it. Conclusion. The data obtained indicate a high level of homogeneity of the sample in the village . Turukhansk, regardless of the presence of the disease, about the low level of detection and control over the course of COVID-19. We observe the formation of a chronic inflammatory process against the background of the prevalence of pro-inflammatory function and an increase in the concentration of pro-inflammatory cytokines, which can subsequently deplete the body's resources and contribute to the development of additional complications.http://discover-journal.ru/jour/index.php/sjlsa/article/view/967covid-19cytokineschemokinesinterferons |
| spellingShingle | Vasilii D. Belenyuk Alexander A. Sinyakov Ekaterina O. Shavrina Olga L. Moskalenko FEATURES OF CYTOKINE PRODUCTION DURING REHABILITATION AFTER COVID-19 IN PEOPLE LIVING IN THE NORTHERN REGIONS OF SIBERIA Siberian Journal of Life Sciences and Agriculture covid-19 cytokines chemokines interferons |
| title | FEATURES OF CYTOKINE PRODUCTION DURING REHABILITATION AFTER COVID-19 IN PEOPLE LIVING IN THE NORTHERN REGIONS OF SIBERIA |
| title_full | FEATURES OF CYTOKINE PRODUCTION DURING REHABILITATION AFTER COVID-19 IN PEOPLE LIVING IN THE NORTHERN REGIONS OF SIBERIA |
| title_fullStr | FEATURES OF CYTOKINE PRODUCTION DURING REHABILITATION AFTER COVID-19 IN PEOPLE LIVING IN THE NORTHERN REGIONS OF SIBERIA |
| title_full_unstemmed | FEATURES OF CYTOKINE PRODUCTION DURING REHABILITATION AFTER COVID-19 IN PEOPLE LIVING IN THE NORTHERN REGIONS OF SIBERIA |
| title_short | FEATURES OF CYTOKINE PRODUCTION DURING REHABILITATION AFTER COVID-19 IN PEOPLE LIVING IN THE NORTHERN REGIONS OF SIBERIA |
| title_sort | features of cytokine production during rehabilitation after covid 19 in people living in the northern regions of siberia |
| topic | covid-19 cytokines chemokines interferons |
| url | http://discover-journal.ru/jour/index.php/sjlsa/article/view/967 |
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