Portal venous and hepatic artery hemodynamic variation in non-alcoholic fatty liver disease
Abstract Background Non-alcoholic fatty liver disease remains asymptomatic until advanced disease, when risk factor modification and available treatment become no longer effective. Studies on hepatic vasculature can be informative about parenchymal injury and disease severity through the study of ch...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2021-06-01
|
| Series: | Egyptian Liver Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43066-021-00130-7 |
| _version_ | 1819145565862100992 |
|---|---|
| author | Manal Sabry Tarek Youssef Mohamed Shaker Mohamed Magdy Salama Nourhan Assem Christina Alfons Anwar |
| author_facet | Manal Sabry Tarek Youssef Mohamed Shaker Mohamed Magdy Salama Nourhan Assem Christina Alfons Anwar |
| author_sort | Manal Sabry |
| collection | DOAJ |
| description | Abstract Background Non-alcoholic fatty liver disease remains asymptomatic until advanced disease, when risk factor modification and available treatment become no longer effective. Studies on hepatic vasculature can be informative about parenchymal injury and disease severity through the study of changes affecting vascular compliance. This study aimed to study portal vein and hepatic artery hemodynamic variation in non-alcoholic fatty liver and to correlate it with disease severity. Results This case control study included 80 participants; those were further divided into four groups; healthy volunteers and non-alcoholic fatty liver disease patients’ grade 1, 2, and 3. We did anthropometric measures, laboratory tests, transient elastography, and Doppler ultrasound for all participants, and then we collected the data and analyzed it using SPSS version 25. Doppler findings showed that peak maximum velocity, peak minimum velocity, mean flow velocity, portal vein pulsatility index of portal vein, and hepatic artery resistivity index were significantly lower in non-alcoholic fatty liver disease patients than in healthy people. All indices were indirectly proportionate to the grade of the disease except for peak minimum velocity which was significantly lower on comparing grade 3 patients with grades 1 and 2 patients. Conclusions Reduction of portal flow and increase in hepatic artery flow in fatty liver correlates with disease severity and can help as a non-invasive measure in diagnosis and grading of non-alcoholic fatty liver disease. |
| first_indexed | 2024-12-22T13:00:03Z |
| format | Article |
| id | doaj.art-54836a81432343ac9e62e53926b4d67d |
| institution | Directory Open Access Journal |
| issn | 2090-6226 |
| language | English |
| last_indexed | 2024-12-22T13:00:03Z |
| publishDate | 2021-06-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Egyptian Liver Journal |
| spelling | doaj.art-54836a81432343ac9e62e53926b4d67d2022-12-21T18:25:01ZengSpringerOpenEgyptian Liver Journal2090-62262021-06-011111610.1186/s43066-021-00130-7Portal venous and hepatic artery hemodynamic variation in non-alcoholic fatty liver diseaseManal Sabry0Tarek Youssef1Mohamed Shaker2Mohamed Magdy Salama3Nourhan Assem4Christina Alfons Anwar5Gastroenterology and Hepatology Unit, Internal Medicine Department Faculty of Medicine, Ain Shams UniversityGastroenterology and Hepatology Unit, Internal Medicine Department Faculty of Medicine, Ain Shams UniversityRadiology Department Faculty of Medicine, Ain Shams UniversityGastroenterology and Hepatology Unit, Internal Medicine Department Faculty of Medicine, Ain Shams UniversityGastroenterology and Hepatology Unit, Internal Medicine Department Faculty of Medicine, Ain Shams UniversityGastroenterology and Hepatology Unit, Internal Medicine Department Faculty of Medicine, Ain Shams UniversityAbstract Background Non-alcoholic fatty liver disease remains asymptomatic until advanced disease, when risk factor modification and available treatment become no longer effective. Studies on hepatic vasculature can be informative about parenchymal injury and disease severity through the study of changes affecting vascular compliance. This study aimed to study portal vein and hepatic artery hemodynamic variation in non-alcoholic fatty liver and to correlate it with disease severity. Results This case control study included 80 participants; those were further divided into four groups; healthy volunteers and non-alcoholic fatty liver disease patients’ grade 1, 2, and 3. We did anthropometric measures, laboratory tests, transient elastography, and Doppler ultrasound for all participants, and then we collected the data and analyzed it using SPSS version 25. Doppler findings showed that peak maximum velocity, peak minimum velocity, mean flow velocity, portal vein pulsatility index of portal vein, and hepatic artery resistivity index were significantly lower in non-alcoholic fatty liver disease patients than in healthy people. All indices were indirectly proportionate to the grade of the disease except for peak minimum velocity which was significantly lower on comparing grade 3 patients with grades 1 and 2 patients. Conclusions Reduction of portal flow and increase in hepatic artery flow in fatty liver correlates with disease severity and can help as a non-invasive measure in diagnosis and grading of non-alcoholic fatty liver disease.https://doi.org/10.1186/s43066-021-00130-7Non-alcoholic fatty liverHepatic arteryPortal vein |
| spellingShingle | Manal Sabry Tarek Youssef Mohamed Shaker Mohamed Magdy Salama Nourhan Assem Christina Alfons Anwar Portal venous and hepatic artery hemodynamic variation in non-alcoholic fatty liver disease Egyptian Liver Journal Non-alcoholic fatty liver Hepatic artery Portal vein |
| title | Portal venous and hepatic artery hemodynamic variation in non-alcoholic fatty liver disease |
| title_full | Portal venous and hepatic artery hemodynamic variation in non-alcoholic fatty liver disease |
| title_fullStr | Portal venous and hepatic artery hemodynamic variation in non-alcoholic fatty liver disease |
| title_full_unstemmed | Portal venous and hepatic artery hemodynamic variation in non-alcoholic fatty liver disease |
| title_short | Portal venous and hepatic artery hemodynamic variation in non-alcoholic fatty liver disease |
| title_sort | portal venous and hepatic artery hemodynamic variation in non alcoholic fatty liver disease |
| topic | Non-alcoholic fatty liver Hepatic artery Portal vein |
| url | https://doi.org/10.1186/s43066-021-00130-7 |
| work_keys_str_mv | AT manalsabry portalvenousandhepaticarteryhemodynamicvariationinnonalcoholicfattyliverdisease AT tarekyoussef portalvenousandhepaticarteryhemodynamicvariationinnonalcoholicfattyliverdisease AT mohamedshaker portalvenousandhepaticarteryhemodynamicvariationinnonalcoholicfattyliverdisease AT mohamedmagdysalama portalvenousandhepaticarteryhemodynamicvariationinnonalcoholicfattyliverdisease AT nourhanassem portalvenousandhepaticarteryhemodynamicvariationinnonalcoholicfattyliverdisease AT christinaalfonsanwar portalvenousandhepaticarteryhemodynamicvariationinnonalcoholicfattyliverdisease |