Liver enzymes serum levels in patients with chronic kidney disease on hemodialysis: a comprehensive review
We reviewed the literature regarding the serum levels of the enzymes aspartate aminotransferase, alanine aminotransferase, and gamma-glutamyl transferase in patients with chronic kidney disease on hemodialysis with and without viral hepatitis. Original articles published up to January 2013 on adult...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier España
2014-04-01
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| Series: | Clinics |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322014000400271&lng=en&tlng=en |
| _version_ | 1828807577554649088 |
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| author | Luís Henrique Bezerra Cavalcanti Sette Edmundo Pessoa de Almeida Lopes |
| author_facet | Luís Henrique Bezerra Cavalcanti Sette Edmundo Pessoa de Almeida Lopes |
| author_sort | Luís Henrique Bezerra Cavalcanti Sette |
| collection | DOAJ |
| description | We reviewed the literature regarding the serum levels of the enzymes aspartate aminotransferase, alanine aminotransferase, and gamma-glutamyl transferase in patients with chronic kidney disease on hemodialysis with and without viral hepatitis. Original articles published up to January 2013 on adult patients with chronic kidney disease on hemodialysis were selected. These articles contained the words “transaminases” “aspartate aminotransferase” “alanine aminotransferase” “gamma glutamyl transferase,” “liver enzymes”, AND “dialysis” OR “hemodialysis”. A total of 823 articles were retrieved. After applying the inclusion and exclusion criteria, 49 articles were selected. The patients with chronic kidney disease on hemodialysis had reduced serum levels of aminotransferases due to hemodilution, lower pyridoxine levels, or elevated homocysteine levels. The chronic kidney disease patients on hemodialysis infected with the hepatitis C virus also had lower aminotransferase levels compared with the infected patients without chronic kidney disease. This reduction is in part due to decreased viremia caused by the dialysis method, the production of a hepatocyte growth factor and endogenous interferon-α, and lymphocyte activation, which decreases viral action on hepatocytes. Few studies were retrieved on gamma-glutamyl transferase serum levels; those found reported that there were no differences between the patients with or without chronic kidney disease. The serum aminotransferase levels were lower in the patients with chronic kidney disease on hemodialysis (with or without viral hepatitis) than in the patients with normal renal function; this reduction has a multifactorial origin. |
| first_indexed | 2024-12-12T08:26:53Z |
| format | Article |
| id | doaj.art-5484139fb0cd4aabb40d1c0e1c33c53f |
| institution | Directory Open Access Journal |
| issn | 1980-5322 |
| language | English |
| last_indexed | 2024-12-12T08:26:53Z |
| publishDate | 2014-04-01 |
| publisher | Elsevier España |
| record_format | Article |
| series | Clinics |
| spelling | doaj.art-5484139fb0cd4aabb40d1c0e1c33c53f2022-12-22T00:31:13ZengElsevier EspañaClinics1980-53222014-04-0169427127810.6061/clinics/2014(04)09S1807-59322014000400271Liver enzymes serum levels in patients with chronic kidney disease on hemodialysis: a comprehensive reviewLuís Henrique Bezerra Cavalcanti SetteEdmundo Pessoa de Almeida LopesWe reviewed the literature regarding the serum levels of the enzymes aspartate aminotransferase, alanine aminotransferase, and gamma-glutamyl transferase in patients with chronic kidney disease on hemodialysis with and without viral hepatitis. Original articles published up to January 2013 on adult patients with chronic kidney disease on hemodialysis were selected. These articles contained the words “transaminases” “aspartate aminotransferase” “alanine aminotransferase” “gamma glutamyl transferase,” “liver enzymes”, AND “dialysis” OR “hemodialysis”. A total of 823 articles were retrieved. After applying the inclusion and exclusion criteria, 49 articles were selected. The patients with chronic kidney disease on hemodialysis had reduced serum levels of aminotransferases due to hemodilution, lower pyridoxine levels, or elevated homocysteine levels. The chronic kidney disease patients on hemodialysis infected with the hepatitis C virus also had lower aminotransferase levels compared with the infected patients without chronic kidney disease. This reduction is in part due to decreased viremia caused by the dialysis method, the production of a hepatocyte growth factor and endogenous interferon-α, and lymphocyte activation, which decreases viral action on hepatocytes. Few studies were retrieved on gamma-glutamyl transferase serum levels; those found reported that there were no differences between the patients with or without chronic kidney disease. The serum aminotransferase levels were lower in the patients with chronic kidney disease on hemodialysis (with or without viral hepatitis) than in the patients with normal renal function; this reduction has a multifactorial origin.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322014000400271&lng=en&tlng=enTransaminasesAspartate AminotransferaseAlanine AminotransferaseGamma-Glutamyl TransferaseDialysis |
| spellingShingle | Luís Henrique Bezerra Cavalcanti Sette Edmundo Pessoa de Almeida Lopes Liver enzymes serum levels in patients with chronic kidney disease on hemodialysis: a comprehensive review Clinics Transaminases Aspartate Aminotransferase Alanine Aminotransferase Gamma-Glutamyl Transferase Dialysis |
| title | Liver enzymes serum levels in patients with chronic kidney disease on hemodialysis: a comprehensive review |
| title_full | Liver enzymes serum levels in patients with chronic kidney disease on hemodialysis: a comprehensive review |
| title_fullStr | Liver enzymes serum levels in patients with chronic kidney disease on hemodialysis: a comprehensive review |
| title_full_unstemmed | Liver enzymes serum levels in patients with chronic kidney disease on hemodialysis: a comprehensive review |
| title_short | Liver enzymes serum levels in patients with chronic kidney disease on hemodialysis: a comprehensive review |
| title_sort | liver enzymes serum levels in patients with chronic kidney disease on hemodialysis a comprehensive review |
| topic | Transaminases Aspartate Aminotransferase Alanine Aminotransferase Gamma-Glutamyl Transferase Dialysis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322014000400271&lng=en&tlng=en |
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