Is midazolam superior to triclofos and hydroxyzine as premedicant in children?
Background: Search for an ideal premedicant drug for children is still on. A prospective, randomized trial was conducted to compare the efficacy of midazolam, triclofos and hydroxyzine as premedication in children undergoing lower abdominal surgeries. Materials and Methods: Sixty American Society o...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2014-01-01
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| Series: | Journal of Anaesthesiology Clinical Pharmacology |
| Subjects: | |
| Online Access: | http://www.joacp.org/article.asp?issn=0970-9185;year=2014;volume=30;issue=1;spage=53;epage=58;aulast=Chaudhary |
| _version_ | 1817997327382609920 |
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| author | Sujata Chaudhary Reena Jindal Gautam Girotra Rashmi Salhotra Rajesh Singh Rautela Ashok Kumar Sethi |
| author_facet | Sujata Chaudhary Reena Jindal Gautam Girotra Rashmi Salhotra Rajesh Singh Rautela Ashok Kumar Sethi |
| author_sort | Sujata Chaudhary |
| collection | DOAJ |
| description | Background: Search for an ideal premedicant drug for children is still on. A prospective, randomized trial was conducted to compare the efficacy of midazolam, triclofos and hydroxyzine as premedication in children undergoing lower abdominal surgeries.
Materials and Methods: Sixty American Society of Anesthesiologists I or II patients 2-8 years of age, scheduled for elective lower abdominal surgery were included. The patients were randomly divided into three groups M, T and H of 20 children each who received midazolam 0.5 mg/kg, triclofos 75 mg/kg and hydroxyzine 0.5 mg/kg respectively, orally 60 min before surgery. The acceptability of drugs, level of sedation, anxiety during separation and on mask application was assessed.
Results: The acceptability of midazolam and hydroxyzine was better than triclofos. Hydroxyzine was found to have lesser sedative effect as compared to both midazolam and triclofos. No major adverse effects were observed.
Conclusion: Midazolam was found to be a better premedicant in terms of sedation, anxiolysis and safety. |
| first_indexed | 2024-04-14T02:35:30Z |
| format | Article |
| id | doaj.art-54851f4fd94b4d1ab3c05d5b364e018c |
| institution | Directory Open Access Journal |
| issn | 0970-9185 |
| language | English |
| last_indexed | 2024-04-14T02:35:30Z |
| publishDate | 2014-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Anaesthesiology Clinical Pharmacology |
| spelling | doaj.art-54851f4fd94b4d1ab3c05d5b364e018c2022-12-22T02:17:26ZengWolters Kluwer Medknow PublicationsJournal of Anaesthesiology Clinical Pharmacology0970-91852014-01-01301535810.4103/0970-9185.125704Is midazolam superior to triclofos and hydroxyzine as premedicant in children?Sujata ChaudharyReena JindalGautam GirotraRashmi SalhotraRajesh Singh RautelaAshok Kumar SethiBackground: Search for an ideal premedicant drug for children is still on. A prospective, randomized trial was conducted to compare the efficacy of midazolam, triclofos and hydroxyzine as premedication in children undergoing lower abdominal surgeries. Materials and Methods: Sixty American Society of Anesthesiologists I or II patients 2-8 years of age, scheduled for elective lower abdominal surgery were included. The patients were randomly divided into three groups M, T and H of 20 children each who received midazolam 0.5 mg/kg, triclofos 75 mg/kg and hydroxyzine 0.5 mg/kg respectively, orally 60 min before surgery. The acceptability of drugs, level of sedation, anxiety during separation and on mask application was assessed. Results: The acceptability of midazolam and hydroxyzine was better than triclofos. Hydroxyzine was found to have lesser sedative effect as compared to both midazolam and triclofos. No major adverse effects were observed. Conclusion: Midazolam was found to be a better premedicant in terms of sedation, anxiolysis and safety.http://www.joacp.org/article.asp?issn=0970-9185;year=2014;volume=30;issue=1;spage=53;epage=58;aulast=ChaudharyChildrenhydroxyzinemidazolampremedicationtriclofos |
| spellingShingle | Sujata Chaudhary Reena Jindal Gautam Girotra Rashmi Salhotra Rajesh Singh Rautela Ashok Kumar Sethi Is midazolam superior to triclofos and hydroxyzine as premedicant in children? Journal of Anaesthesiology Clinical Pharmacology Children hydroxyzine midazolam premedication triclofos |
| title | Is midazolam superior to triclofos and hydroxyzine as premedicant in children? |
| title_full | Is midazolam superior to triclofos and hydroxyzine as premedicant in children? |
| title_fullStr | Is midazolam superior to triclofos and hydroxyzine as premedicant in children? |
| title_full_unstemmed | Is midazolam superior to triclofos and hydroxyzine as premedicant in children? |
| title_short | Is midazolam superior to triclofos and hydroxyzine as premedicant in children? |
| title_sort | is midazolam superior to triclofos and hydroxyzine as premedicant in children |
| topic | Children hydroxyzine midazolam premedication triclofos |
| url | http://www.joacp.org/article.asp?issn=0970-9185;year=2014;volume=30;issue=1;spage=53;epage=58;aulast=Chaudhary |
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