<i>Ixodes ricinus</i> Salivary Serpin Iripin-8 Inhibits the Intrinsic Pathway of Coagulation and Complement

<i>Ixodes ricinus</i> Salivary Serpin Iripin-8 Inhibits the Intrinsic Pathway of Coagulation and Complement

Tick saliva is a rich source of antihemostatic, anti-inflammatory, and immunomodulatory molecules that actively help the tick to finish its blood meal. Moreover, these molecules facilitate the transmission of tick-borne pathogens. Here we present the functional and structural characterization of Iri...

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Bibliographic Details
Main Authors: Jan Kotál, Stéphanie G. I. Polderdijk, Helena Langhansová, Monika Ederová, Larissa A. Martins, Zuzana Beránková, Adéla Chlastáková, Ondřej Hajdušek, Michail Kotsyfakis, James A. Huntington, Jindřich Chmelař
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
blood coagulation
crystal structure
<i>Ixodes ricinus</i>
parasite
saliva
serpin
Online Access:https://www.mdpi.com/1422-0067/22/17/9480

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