Successful clearance of persistent SARS-CoV-2 asymptomatic infection following a single dose of Ad5-nCoV vaccine
Abstract Persistent asymptomatic (PA) SARS-CoV-2 infections have been identified. The immune responses in these patients are unclear, and the development of effective treatments for these patients is needed. Here, we report a cohort of 23 PA cases carrying viral RNA for up to 191 days. PA cases disp...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2023-03-01
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| Series: | Signal Transduction and Targeted Therapy |
| Online Access: | https://doi.org/10.1038/s41392-023-01345-3 |
| _version_ | 1827982562186756096 |
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| author | Shaofu Qiu Zhao Chen Airu Zhu Qiuhui Zeng Hongbo Liu Xiaoqing Liu Feng Ye Yingkang Jin Jie Wu Chaojie Yang Qi Wang Fangli Chen Lan Chen Sai Tian Xinying Du Qingtao Hu Jinling Cheng Canjie Chen Fang Li Jing Sun Yanqun Wang Jingxian Zhao Jincun Zhao Hongbin Song |
| author_facet | Shaofu Qiu Zhao Chen Airu Zhu Qiuhui Zeng Hongbo Liu Xiaoqing Liu Feng Ye Yingkang Jin Jie Wu Chaojie Yang Qi Wang Fangli Chen Lan Chen Sai Tian Xinying Du Qingtao Hu Jinling Cheng Canjie Chen Fang Li Jing Sun Yanqun Wang Jingxian Zhao Jincun Zhao Hongbin Song |
| author_sort | Shaofu Qiu |
| collection | DOAJ |
| description | Abstract Persistent asymptomatic (PA) SARS-CoV-2 infections have been identified. The immune responses in these patients are unclear, and the development of effective treatments for these patients is needed. Here, we report a cohort of 23 PA cases carrying viral RNA for up to 191 days. PA cases displayed low levels of inflammatory and interferon response, weak antibody response, diminished circulating follicular helper T cells (cTfh), and inadequate specific CD4+ and CD8+ T-cell responses during infection, which is distinct from symptomatic infections and resembling impaired immune activation. Administration of a single dose of Ad5-nCoV vaccine to 10 of these PA cases elicited rapid and robust antibody responses as well as coordinated B-cell and cTfh responses, resulting in successful viral clearance. Vaccine-induced antibodies were able to neutralize various variants of concern and persisted for over 6 months, indicating long-term protection. Therefore, our study provides an insight into the immune status of PA infections and highlights vaccination as a potential treatment for prolonged SARS-CoV-2 infections. |
| first_indexed | 2024-04-09T22:34:53Z |
| format | Article |
| id | doaj.art-5487577ee83e424aa68fb0b25e8098eb |
| institution | Directory Open Access Journal |
| issn | 2059-3635 |
| language | English |
| last_indexed | 2024-04-09T22:34:53Z |
| publishDate | 2023-03-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Signal Transduction and Targeted Therapy |
| spelling | doaj.art-5487577ee83e424aa68fb0b25e8098eb2023-03-22T12:31:10ZengNature Publishing GroupSignal Transduction and Targeted Therapy2059-36352023-03-018111110.1038/s41392-023-01345-3Successful clearance of persistent SARS-CoV-2 asymptomatic infection following a single dose of Ad5-nCoV vaccineShaofu Qiu0Zhao Chen1Airu Zhu2Qiuhui Zeng3Hongbo Liu4Xiaoqing Liu5Feng Ye6Yingkang Jin7Jie Wu8Chaojie Yang9Qi Wang10Fangli Chen11Lan Chen12Sai Tian13Xinying Du14Qingtao Hu15Jinling Cheng16Canjie Chen17Fang Li18Jing Sun19Yanqun Wang20Jingxian Zhao21Jincun Zhao22Hongbin Song23The Chinese PLA Center for Disease Control and PreventionState Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical UniversityState Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical UniversityState Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical UniversityThe Chinese PLA Center for Disease Control and PreventionState Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical UniversityState Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical UniversityPediatric Pulmonary Department, Guangzhou Women and Children’s Medical Center, Guangzhou Medical UniversityGuangdong Provincial Center for Disease Control and PreventionThe Chinese PLA Center for Disease Control and PreventionThe Chinese PLA Center for Disease Control and PreventionState Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical UniversityState Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical UniversityThe Chinese PLA Center for Disease Control and PreventionThe Chinese PLA Center for Disease Control and PreventionState Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical UniversityState Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical UniversityState Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical UniversityState Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical UniversityState Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical UniversityState Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical UniversityState Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical UniversityState Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical UniversityThe Chinese PLA Center for Disease Control and PreventionAbstract Persistent asymptomatic (PA) SARS-CoV-2 infections have been identified. The immune responses in these patients are unclear, and the development of effective treatments for these patients is needed. Here, we report a cohort of 23 PA cases carrying viral RNA for up to 191 days. PA cases displayed low levels of inflammatory and interferon response, weak antibody response, diminished circulating follicular helper T cells (cTfh), and inadequate specific CD4+ and CD8+ T-cell responses during infection, which is distinct from symptomatic infections and resembling impaired immune activation. Administration of a single dose of Ad5-nCoV vaccine to 10 of these PA cases elicited rapid and robust antibody responses as well as coordinated B-cell and cTfh responses, resulting in successful viral clearance. Vaccine-induced antibodies were able to neutralize various variants of concern and persisted for over 6 months, indicating long-term protection. Therefore, our study provides an insight into the immune status of PA infections and highlights vaccination as a potential treatment for prolonged SARS-CoV-2 infections.https://doi.org/10.1038/s41392-023-01345-3 |
| spellingShingle | Shaofu Qiu Zhao Chen Airu Zhu Qiuhui Zeng Hongbo Liu Xiaoqing Liu Feng Ye Yingkang Jin Jie Wu Chaojie Yang Qi Wang Fangli Chen Lan Chen Sai Tian Xinying Du Qingtao Hu Jinling Cheng Canjie Chen Fang Li Jing Sun Yanqun Wang Jingxian Zhao Jincun Zhao Hongbin Song Successful clearance of persistent SARS-CoV-2 asymptomatic infection following a single dose of Ad5-nCoV vaccine Signal Transduction and Targeted Therapy |
| title | Successful clearance of persistent SARS-CoV-2 asymptomatic infection following a single dose of Ad5-nCoV vaccine |
| title_full | Successful clearance of persistent SARS-CoV-2 asymptomatic infection following a single dose of Ad5-nCoV vaccine |
| title_fullStr | Successful clearance of persistent SARS-CoV-2 asymptomatic infection following a single dose of Ad5-nCoV vaccine |
| title_full_unstemmed | Successful clearance of persistent SARS-CoV-2 asymptomatic infection following a single dose of Ad5-nCoV vaccine |
| title_short | Successful clearance of persistent SARS-CoV-2 asymptomatic infection following a single dose of Ad5-nCoV vaccine |
| title_sort | successful clearance of persistent sars cov 2 asymptomatic infection following a single dose of ad5 ncov vaccine |
| url | https://doi.org/10.1038/s41392-023-01345-3 |
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