Systemic Mesenchymal Stem Cell-Derived Exosomes Reduce Myocardial Infarct Size: Characterization With MRI in a Porcine Model

Systemic Mesenchymal Stem Cell-Derived Exosomes Reduce Myocardial Infarct Size: Characterization With MRI in a Porcine Model

The observations that mesenchymal stem cells (MSCs) exert cardiac protection and repair via their secretome with the active component(s) identified as exosomes underpinned our test of the efficacy of MSC exosomes in a porcine model of myocardial infarction (MI) when administered systemically by the...

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Bibliographic Details
Main Authors: Christopher J. Charles, Renee R. Li, Teresa Yeung, Stephane M. Ibraham Mazlan, Ruenn Chai Lai, Dominique P. V. de Kleijn, Sai Kiang Lim, A. Mark Richards
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
mesenchymal stem cells
exosomes
porcine (pig) model
myocardial infarction
left ventricular remodeling
cardiac fibrosis
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2020.601990/full

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