Factors associated with quality of life in patients with severe asthma: the impact of pharmacotherapy
ABSTRACT OBJECTIVE: To identify, characterize, and quantify associations of various factors with quality of life (QoL) in patients with asthma, according to the pharmacotherapy employed. METHODS: This was a cross-sectional study involving 49 patients (≥ 18 years of age) with severe uncontrolled...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Pneumologia e Tisiologia
2015-12-01
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| Series: | Jornal Brasileiro de Pneumologia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132015000600496&lng=en&tlng=en |
| _version_ | 1818011485844013056 |
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| author | Daiane Silva Souza Lúcia de Araújo Costa Beisl Noblat Pablo de Moura Santos |
| author_facet | Daiane Silva Souza Lúcia de Araújo Costa Beisl Noblat Pablo de Moura Santos |
| author_sort | Daiane Silva Souza |
| collection | DOAJ |
| description | ABSTRACT OBJECTIVE: To identify, characterize, and quantify associations of various factors with quality of life (QoL) in patients with asthma, according to the pharmacotherapy employed. METHODS: This was a cross-sectional study involving 49 patients (≥ 18 years of age) with severe uncontrolled or refractory asthma treated at a specialized outpatient clinic of the Brazilian Unified Health Care System, regularly using high doses of inhaled corticosteroids (ICs) or other medications, and presenting comorbidities. At a single time point, QoL was assessed with the Asthma Quality of Life Questionnaire (AQLQ). The overall AQLQ score and those of its domains were correlated with demographic variables (gender and age); Asthma Control Questionnaire score; pharmacotherapy (initial IC dose, inhaler devices, and polytherapy); and comorbidities. RESULTS: Better AQLQ scores were associated with asthma control-overall (OR = 0.38; 95% CI: 0.004-0.341; p < 0.001), "symptoms" domain (OR = 0.086; 95% CI: 0.016-0.476; p = 0.001), and "emotional function" domain (OR = 0.086; 95% CI: 0.016-0.476; p = 0.001)-and with IC dose ≤ 800 µg-"activity limitation" domain (OR = 0.249; 95% CI: 0.070-0.885; p = 0.029). Worse AQLQ scores were associated with polytherapy-"activity limitation" domain (OR = 3.651; 95% CI: 1.061-12.561; p = 0.036)-and number of comorbidities ≤ 5-"environmental stimuli" domain (OR = 5.042; 95% CI: 1.316-19.317; p = 0.015). CONCLUSIONS: Our results, the importance of this issue, and the lack of studies taking pharmacotherapy into consideration warrant longitudinal studies to establish a causal relationship between the identified factors and QoL in asthma patients. |
| first_indexed | 2024-04-14T06:08:29Z |
| format | Article |
| id | doaj.art-548c4ff0d26c4f3ab3e6e8a18a40fdff |
| institution | Directory Open Access Journal |
| issn | 1806-3756 |
| language | English |
| last_indexed | 2024-04-14T06:08:29Z |
| publishDate | 2015-12-01 |
| publisher | Sociedade Brasileira de Pneumologia e Tisiologia |
| record_format | Article |
| series | Jornal Brasileiro de Pneumologia |
| spelling | doaj.art-548c4ff0d26c4f3ab3e6e8a18a40fdff2022-12-22T02:08:26ZengSociedade Brasileira de Pneumologia e TisiologiaJornal Brasileiro de Pneumologia1806-37562015-12-0141649650110.1590/S1806-37562015000004545S1806-37132015000600496Factors associated with quality of life in patients with severe asthma: the impact of pharmacotherapyDaiane Silva SouzaLúcia de Araújo Costa Beisl NoblatPablo de Moura SantosABSTRACT OBJECTIVE: To identify, characterize, and quantify associations of various factors with quality of life (QoL) in patients with asthma, according to the pharmacotherapy employed. METHODS: This was a cross-sectional study involving 49 patients (≥ 18 years of age) with severe uncontrolled or refractory asthma treated at a specialized outpatient clinic of the Brazilian Unified Health Care System, regularly using high doses of inhaled corticosteroids (ICs) or other medications, and presenting comorbidities. At a single time point, QoL was assessed with the Asthma Quality of Life Questionnaire (AQLQ). The overall AQLQ score and those of its domains were correlated with demographic variables (gender and age); Asthma Control Questionnaire score; pharmacotherapy (initial IC dose, inhaler devices, and polytherapy); and comorbidities. RESULTS: Better AQLQ scores were associated with asthma control-overall (OR = 0.38; 95% CI: 0.004-0.341; p < 0.001), "symptoms" domain (OR = 0.086; 95% CI: 0.016-0.476; p = 0.001), and "emotional function" domain (OR = 0.086; 95% CI: 0.016-0.476; p = 0.001)-and with IC dose ≤ 800 µg-"activity limitation" domain (OR = 0.249; 95% CI: 0.070-0.885; p = 0.029). Worse AQLQ scores were associated with polytherapy-"activity limitation" domain (OR = 3.651; 95% CI: 1.061-12.561; p = 0.036)-and number of comorbidities ≤ 5-"environmental stimuli" domain (OR = 5.042; 95% CI: 1.316-19.317; p = 0.015). CONCLUSIONS: Our results, the importance of this issue, and the lack of studies taking pharmacotherapy into consideration warrant longitudinal studies to establish a causal relationship between the identified factors and QoL in asthma patients.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132015000600496&lng=en&tlng=enAsmaAsma/quimioterapiaQualidade de VidaConduta do tratamento medicamentoso |
| spellingShingle | Daiane Silva Souza Lúcia de Araújo Costa Beisl Noblat Pablo de Moura Santos Factors associated with quality of life in patients with severe asthma: the impact of pharmacotherapy Jornal Brasileiro de Pneumologia Asma Asma/quimioterapia Qualidade de Vida Conduta do tratamento medicamentoso |
| title | Factors associated with quality of life in patients with severe asthma: the impact of pharmacotherapy |
| title_full | Factors associated with quality of life in patients with severe asthma: the impact of pharmacotherapy |
| title_fullStr | Factors associated with quality of life in patients with severe asthma: the impact of pharmacotherapy |
| title_full_unstemmed | Factors associated with quality of life in patients with severe asthma: the impact of pharmacotherapy |
| title_short | Factors associated with quality of life in patients with severe asthma: the impact of pharmacotherapy |
| title_sort | factors associated with quality of life in patients with severe asthma the impact of pharmacotherapy |
| topic | Asma Asma/quimioterapia Qualidade de Vida Conduta do tratamento medicamentoso |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132015000600496&lng=en&tlng=en |
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