Hyperbaric Oxygenation as a Possible Therapy of Choice for Infertility Treatment
Endometrial sonographic and color doppler features can be used to predict the occurrence of pregnancy in natural or stimulated cycles. Implantation will usually only take place if the endometrium has reach a certain stage of vascularisation and development. The aim of this study was to evaluate end...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
2006-05-01
|
| Series: | Biomolecules & Biomedicine |
| Subjects: | |
| Online Access: | https://www.bjbms.org/ojs/index.php/bjbms/article/view/3168 |
| _version_ | 1827317238005235712 |
|---|---|
| author | Ana Mitrović Branka Nikolić Svetlana Dragojević Predrag Brkić Aleksandar Ljubić Tomislav Jovanović |
| author_facet | Ana Mitrović Branka Nikolić Svetlana Dragojević Predrag Brkić Aleksandar Ljubić Tomislav Jovanović |
| author_sort | Ana Mitrović |
| collection | DOAJ |
| description |
Endometrial sonographic and color doppler features can be used to predict the occurrence of pregnancy in natural or stimulated cycles. Implantation will usually only take place if the endometrium has reach a certain stage of vascularisation and development. The aim of this study was to evaluate endometrial development -- endometrial thickness and reflectivity , subendometrial, endometrial and uterine perfusion, after hyperbaric oxygenation, using transvaginal color doppler. During a three years period 32 women with unexplained infertility were entered into a randomised study. The patients were treated in multiplaced HAUX chamber at pressure of 2.3 ATA during 70 minutes, 7 days consecutively beginning with day 5th of menstrual cycle. The evaluation of effects of hyperbaric oxygen therapy was carried out by transvaginal color doppler sonography which was continuously used starting from 8th day of menstrual cycle until the ovulation in the cycles when the therapy was applied , one month before and one month after the therapy. Folliculometry in the cycles when hyperbaric oxygen therapy at 2.3 ATA was applied, indicated an excellent response of endometrium. Thickness of endometrium at the time of ovulation was 11.0 +/- 2.6 mm. Desirable quality of endometrium was significantly better in the cycle when HBO therapy had been applied (p< 0.001). The doppler flowmetry of the uterine arteries indicated that the uterine blood vessel resistance was slightly higher than expected. Mapping of subendometrial blood vessels in the cycles covered by hyperbaric oxygen therapy showed the intensive capillary network of endometrium with low resistance Ri< 0.45. The oxygen used under higher pressure -- oxygen as a drug , may have an extraordinary significance for better outcome of pregnancy implantation by improving endometrial receptivity. If endometrial receptivity is conditioned by adequate vascularisation and oxygenation, then hyperbaric oxygen therapy is the treatment of choice.
|
| first_indexed | 2024-04-24T23:31:23Z |
| format | Article |
| id | doaj.art-548d656500bb4aabbde4d619625d1b50 |
| institution | Directory Open Access Journal |
| issn | 2831-0896 2831-090X |
| language | English |
| last_indexed | 2024-04-24T23:31:23Z |
| publishDate | 2006-05-01 |
| publisher | Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina |
| record_format | Article |
| series | Biomolecules & Biomedicine |
| spelling | doaj.art-548d656500bb4aabbde4d619625d1b502024-03-15T14:42:27ZengAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaBiomolecules & Biomedicine2831-08962831-090X2006-05-016210.17305/bjbms.2006.3168709Hyperbaric Oxygenation as a Possible Therapy of Choice for Infertility TreatmentAna Mitrović0Branka Nikolić1Svetlana Dragojević2Predrag Brkić3Aleksandar Ljubić4Tomislav Jovanović5University Clinic of Gynecology and Obstetrics "Narodni front", Narodni front 62, Faculty of Medicine, University of Belgrade Institute for Hyperbaric MedicineUniversity Clinic of Gynecology and Obstetrics "Narodni front", Narodni front 62, Faculty of Medicine, University of BelgradeUniversity Clinic of Gynecology and Obstetrics "Narodni front", Narodni front 62, Faculty of Medicine, University of BelgradeInstitute of Physiology, Faculty of Medicine, University of BelgradeInstitute of Gynecology and Obstetrics, Faculty of Medicine, University of BelgradeInstitute of Physiology, Faculty of Medicine, University of Belgrade Institute for Hyperbaric Medicine Endometrial sonographic and color doppler features can be used to predict the occurrence of pregnancy in natural or stimulated cycles. Implantation will usually only take place if the endometrium has reach a certain stage of vascularisation and development. The aim of this study was to evaluate endometrial development -- endometrial thickness and reflectivity , subendometrial, endometrial and uterine perfusion, after hyperbaric oxygenation, using transvaginal color doppler. During a three years period 32 women with unexplained infertility were entered into a randomised study. The patients were treated in multiplaced HAUX chamber at pressure of 2.3 ATA during 70 minutes, 7 days consecutively beginning with day 5th of menstrual cycle. The evaluation of effects of hyperbaric oxygen therapy was carried out by transvaginal color doppler sonography which was continuously used starting from 8th day of menstrual cycle until the ovulation in the cycles when the therapy was applied , one month before and one month after the therapy. Folliculometry in the cycles when hyperbaric oxygen therapy at 2.3 ATA was applied, indicated an excellent response of endometrium. Thickness of endometrium at the time of ovulation was 11.0 +/- 2.6 mm. Desirable quality of endometrium was significantly better in the cycle when HBO therapy had been applied (p< 0.001). The doppler flowmetry of the uterine arteries indicated that the uterine blood vessel resistance was slightly higher than expected. Mapping of subendometrial blood vessels in the cycles covered by hyperbaric oxygen therapy showed the intensive capillary network of endometrium with low resistance Ri< 0.45. The oxygen used under higher pressure -- oxygen as a drug , may have an extraordinary significance for better outcome of pregnancy implantation by improving endometrial receptivity. If endometrial receptivity is conditioned by adequate vascularisation and oxygenation, then hyperbaric oxygen therapy is the treatment of choice. https://www.bjbms.org/ojs/index.php/bjbms/article/view/3168endometrial receptivityhyperbaric therapyinfertility |
| spellingShingle | Ana Mitrović Branka Nikolić Svetlana Dragojević Predrag Brkić Aleksandar Ljubić Tomislav Jovanović Hyperbaric Oxygenation as a Possible Therapy of Choice for Infertility Treatment Biomolecules & Biomedicine endometrial receptivity hyperbaric therapy infertility |
| title | Hyperbaric Oxygenation as a Possible Therapy of Choice for Infertility Treatment |
| title_full | Hyperbaric Oxygenation as a Possible Therapy of Choice for Infertility Treatment |
| title_fullStr | Hyperbaric Oxygenation as a Possible Therapy of Choice for Infertility Treatment |
| title_full_unstemmed | Hyperbaric Oxygenation as a Possible Therapy of Choice for Infertility Treatment |
| title_short | Hyperbaric Oxygenation as a Possible Therapy of Choice for Infertility Treatment |
| title_sort | hyperbaric oxygenation as a possible therapy of choice for infertility treatment |
| topic | endometrial receptivity hyperbaric therapy infertility |
| url | https://www.bjbms.org/ojs/index.php/bjbms/article/view/3168 |
| work_keys_str_mv | AT anamitrovic hyperbaricoxygenationasapossibletherapyofchoiceforinfertilitytreatment AT brankanikolic hyperbaricoxygenationasapossibletherapyofchoiceforinfertilitytreatment AT svetlanadragojevic hyperbaricoxygenationasapossibletherapyofchoiceforinfertilitytreatment AT predragbrkic hyperbaricoxygenationasapossibletherapyofchoiceforinfertilitytreatment AT aleksandarljubic hyperbaricoxygenationasapossibletherapyofchoiceforinfertilitytreatment AT tomislavjovanovic hyperbaricoxygenationasapossibletherapyofchoiceforinfertilitytreatment |