Global differences in the prevalence of the CpG island methylator phenotype of colorectal cancer

Global differences in the prevalence of the CpG island methylator phenotype of colorectal cancer

Abstract Background CpG Island Methylator Phenotype (CIMP) is an epigenetic phenotype in CRC characterized by hypermethylation of CpG islands in promoter regions of tumor suppressor genes, leading to their transcriptional silencing and loss of function. While the prevalence of CRC differs across geo...

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Bibliographic Details
Main Authors: Shailesh Mahesh Advani, Pragati Shailesh Advani, Derek W. Brown, Stacia M. DeSantis, Krittiya Korphaisarn, Helena M. VonVille, Jan Bressler, David S. Lopez, Jennifer S. Davis, Carrie R. Daniel, Amir Mehrvarz Sarshekeh, Dejana Braithwaite, Michael D. Swartz, Scott Kopetz
Format: Article
Language:English
Published: BMC 2019-10-01
Series:BMC Cancer
Subjects:
Epigenetics
Methylation
Geographic
CIMP
Colorectal
Online Access:http://link.springer.com/article/10.1186/s12885-019-6144-9

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