RalB directly triggers invasion downstream Ras by mobilizing the Wave complex

RalB directly triggers invasion downstream Ras by mobilizing the Wave complex

The two Ral GTPases, RalA and RalB, have crucial roles downstream Ras oncoproteins in human cancers; in particular, RalB is involved in invasion and metastasis. However, therapies targeting Ral signalling are not available yet. By a novel optogenetic approach, we found that light-controlled activati...

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Bibliographic Details
Main Authors: Giulia Zago, Irina Veith, Manish Kumar Singh, Laetitia Fuhrmann, Simon De Beco, Amanda Remorino, Saori Takaoka, Marjorie Palmeri, Frédérique Berger, Nathalie Brandon, Ahmed El Marjou, Anne Vincent-Salomon, Jacques Camonis, Mathieu Coppey, Maria Carla Parrini
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-10-01
Series:eLife
Subjects:
Invasion
Ral
breast cancer
Exocyst
Wave
optogenetics
Online Access:https://elifesciences.org/articles/40474

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