Antimicrobial, antioxidant and cytotoxicity potential of Manihot multifida (L.) Crantz (Euphorbiaceae)
Manihot multifida (L.) Crantz (Euphorbiaceae) is widely used in popular medicine for the treatment of infected wounds. This study evaluated thein vitro antioxidant and antimicrobial potential of this species against strains of Gram-positive and Gram-negative bacteria and fungi, known to cause infect...
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| Format: | Article |
| Language: | English |
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Academia Brasileira de Ciências
2015-03-01
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| Series: | Anais da Academia Brasileira de Ciências |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000100303&lng=en&tlng=en |
| _version_ | 1819195423082938368 |
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| author | RODRIGO L. FABRI DANIEL S. DE SÁ ANA PATRÍCIA O. PEREIRA ELITA SCIO DANIEL S. PIMENTA LUCIANA M. CHEDIER |
| author_facet | RODRIGO L. FABRI DANIEL S. DE SÁ ANA PATRÍCIA O. PEREIRA ELITA SCIO DANIEL S. PIMENTA LUCIANA M. CHEDIER |
| author_sort | RODRIGO L. FABRI |
| collection | DOAJ |
| description | Manihot multifida (L.) Crantz (Euphorbiaceae) is widely used in popular medicine for the treatment of infected wounds. This study evaluated thein vitro antioxidant and antimicrobial potential of this species against strains of Gram-positive and Gram-negative bacteria and fungi, known to cause infections in humans. The extracts showed minimal inhibitory concentration (MIC) varying from 39 to 2500 µg/mL for antimicrobial activity. The methanolic extract of fruits, aqueous and hexane extracts of leaves showed a very strong activity against Candida albicans(ATCC 18804) with MIC of 39 µg/mL. Furthermore, the methanolic extract of M. multifida leaves exhibited DPPH (1,1-diphenyl-2-picrylhydrazyl) scavenging potential with inhibitory concentration (IC50) values of 46.9 μg/mL, followed by hexane extract of leaves with IC50 values of 59.2 μg/mL. The cytotoxic activity against brine shrimp was stronger for the methanolic extract of leaves (lethal concentration - LC50 of 15.6 µg/mL). These results suggest that M. multifida has interesting antimicrobial and antioxidant activities. Moreover, these results corroborate the popular use of this specie in treating fungal infections since it demonstrates significant activity againstC. albicans. |
| first_indexed | 2024-12-23T02:12:31Z |
| format | Article |
| id | doaj.art-5493fba3842b4063b121ff44843cef0a |
| institution | Directory Open Access Journal |
| issn | 1678-2690 |
| language | English |
| last_indexed | 2024-12-23T02:12:31Z |
| publishDate | 2015-03-01 |
| publisher | Academia Brasileira de Ciências |
| record_format | Article |
| series | Anais da Academia Brasileira de Ciências |
| spelling | doaj.art-5493fba3842b4063b121ff44843cef0a2022-12-21T18:03:45ZengAcademia Brasileira de CiênciasAnais da Academia Brasileira de Ciências1678-26902015-03-0187130331110.1590/0001-3765201520130251S0001-37652015000100303Antimicrobial, antioxidant and cytotoxicity potential of Manihot multifida (L.) Crantz (Euphorbiaceae)RODRIGO L. FABRIDANIEL S. DE SÁANA PATRÍCIA O. PEREIRAELITA SCIODANIEL S. PIMENTALUCIANA M. CHEDIERManihot multifida (L.) Crantz (Euphorbiaceae) is widely used in popular medicine for the treatment of infected wounds. This study evaluated thein vitro antioxidant and antimicrobial potential of this species against strains of Gram-positive and Gram-negative bacteria and fungi, known to cause infections in humans. The extracts showed minimal inhibitory concentration (MIC) varying from 39 to 2500 µg/mL for antimicrobial activity. The methanolic extract of fruits, aqueous and hexane extracts of leaves showed a very strong activity against Candida albicans(ATCC 18804) with MIC of 39 µg/mL. Furthermore, the methanolic extract of M. multifida leaves exhibited DPPH (1,1-diphenyl-2-picrylhydrazyl) scavenging potential with inhibitory concentration (IC50) values of 46.9 μg/mL, followed by hexane extract of leaves with IC50 values of 59.2 μg/mL. The cytotoxic activity against brine shrimp was stronger for the methanolic extract of leaves (lethal concentration - LC50 of 15.6 µg/mL). These results suggest that M. multifida has interesting antimicrobial and antioxidant activities. Moreover, these results corroborate the popular use of this specie in treating fungal infections since it demonstrates significant activity againstC. albicans.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000100303&lng=en&tlng=enantimicrobianoantioxidanteCandida albicanscitotoxicidadeManihot multifida |
| spellingShingle | RODRIGO L. FABRI DANIEL S. DE SÁ ANA PATRÍCIA O. PEREIRA ELITA SCIO DANIEL S. PIMENTA LUCIANA M. CHEDIER Antimicrobial, antioxidant and cytotoxicity potential of Manihot multifida (L.) Crantz (Euphorbiaceae) Anais da Academia Brasileira de Ciências antimicrobiano antioxidante Candida albicans citotoxicidade Manihot multifida |
| title | Antimicrobial, antioxidant and cytotoxicity potential of Manihot multifida (L.) Crantz (Euphorbiaceae) |
| title_full | Antimicrobial, antioxidant and cytotoxicity potential of Manihot multifida (L.) Crantz (Euphorbiaceae) |
| title_fullStr | Antimicrobial, antioxidant and cytotoxicity potential of Manihot multifida (L.) Crantz (Euphorbiaceae) |
| title_full_unstemmed | Antimicrobial, antioxidant and cytotoxicity potential of Manihot multifida (L.) Crantz (Euphorbiaceae) |
| title_short | Antimicrobial, antioxidant and cytotoxicity potential of Manihot multifida (L.) Crantz (Euphorbiaceae) |
| title_sort | antimicrobial antioxidant and cytotoxicity potential of manihot multifida l crantz euphorbiaceae |
| topic | antimicrobiano antioxidante Candida albicans citotoxicidade Manihot multifida |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000100303&lng=en&tlng=en |
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