Celecoxib inhibits osteoblast maturation by suppressing the expression of Wnt target genes

Celecoxib inhibits osteoblast maturation by suppressing the expression of Wnt target genes

Non-steroidal anti-inflammatory drugs (NSAIDs) have been shown to impair bone healing. We previously reported that in colon cancer cells, celecoxib, a COX-2-selective NSAID, inhibited the canonical Wnt/β-catenin signaling pathway. Since this pathway also plays an important role in osteoblast growth...

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Bibliographic Details
Main Authors:	Akihiro Nagano, Masaki Arioka, Fumi Takahashi-Yanaga, Etsuko Matsuzaki, Toshiyuki Sasaguri
Format:	Article
Language:	English
Published:	Elsevier 2017-01-01
Series:	Journal of Pharmacological Sciences
Subjects:	Osteoblast Celecoxib Wnt/β-catenin signaling pathway Mineralization Fracture healing
Online Access:	http://www.sciencedirect.com/science/article/pii/S1347861316301591

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