Early recurrence of proliferative glomerulonephritis with monoclonal immunoglobulin deposits in a renal allograft

Proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMIDs) is a clinico-pathologic entity, the recurrence of which in the renal allograft has only recently been described. A 55-year-old male presented with rapid deterioration of renal function. Light microscopy showed membran...

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Main Authors: Rohit Tewari, Kusum Joshi, Ashwani Kumar, C S Rayat, Rajaram Iyer, Vinay Sakhuja, Mukut Minz
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2016-01-01
Series:Saudi Journal of Kidney Diseases and Transplantation
Online Access:http://www.sjkdt.org/article.asp?issn=1319-2442;year=2016;volume=27;issue=2;spage=381;epage=385;aulast=Tewari
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author Rohit Tewari
Kusum Joshi
Ashwani Kumar
C S Rayat
Rajaram Iyer
Vinay Sakhuja
Mukut Minz
author_facet Rohit Tewari
Kusum Joshi
Ashwani Kumar
C S Rayat
Rajaram Iyer
Vinay Sakhuja
Mukut Minz
author_sort Rohit Tewari
collection DOAJ
description Proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMIDs) is a clinico-pathologic entity, the recurrence of which in the renal allograft has only recently been described. A 55-year-old male presented with rapid deterioration of renal function. Light microscopy showed membranoproliferative glomerulonephritis with kappa light chain restriction and only one sub-class of IgG. He subsequently underwent renal transplant. Two months later, he developed acute graft dysfunction. Renal biopsy showed a recurrence of the disease. Work up for multiple myeloma was positive. Membranoproliferative pattern of injury in the posttransplant setting has a wide range of differential diagnosis, PGNMID being one of them.
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spelling doaj.art-5495e5daca6748a5a11e1fc8e118845e2022-12-22T00:52:06ZengWolters Kluwer Medknow PublicationsSaudi Journal of Kidney Diseases and Transplantation1319-24422016-01-0127238138510.4103/1319-2442.178568Early recurrence of proliferative glomerulonephritis with monoclonal immunoglobulin deposits in a renal allograftRohit TewariKusum JoshiAshwani KumarC S RayatRajaram IyerVinay SakhujaMukut MinzProliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMIDs) is a clinico-pathologic entity, the recurrence of which in the renal allograft has only recently been described. A 55-year-old male presented with rapid deterioration of renal function. Light microscopy showed membranoproliferative glomerulonephritis with kappa light chain restriction and only one sub-class of IgG. He subsequently underwent renal transplant. Two months later, he developed acute graft dysfunction. Renal biopsy showed a recurrence of the disease. Work up for multiple myeloma was positive. Membranoproliferative pattern of injury in the posttransplant setting has a wide range of differential diagnosis, PGNMID being one of them.http://www.sjkdt.org/article.asp?issn=1319-2442;year=2016;volume=27;issue=2;spage=381;epage=385;aulast=Tewari
spellingShingle Rohit Tewari
Kusum Joshi
Ashwani Kumar
C S Rayat
Rajaram Iyer
Vinay Sakhuja
Mukut Minz
Early recurrence of proliferative glomerulonephritis with monoclonal immunoglobulin deposits in a renal allograft
Saudi Journal of Kidney Diseases and Transplantation
title Early recurrence of proliferative glomerulonephritis with monoclonal immunoglobulin deposits in a renal allograft
title_full Early recurrence of proliferative glomerulonephritis with monoclonal immunoglobulin deposits in a renal allograft
title_fullStr Early recurrence of proliferative glomerulonephritis with monoclonal immunoglobulin deposits in a renal allograft
title_full_unstemmed Early recurrence of proliferative glomerulonephritis with monoclonal immunoglobulin deposits in a renal allograft
title_short Early recurrence of proliferative glomerulonephritis with monoclonal immunoglobulin deposits in a renal allograft
title_sort early recurrence of proliferative glomerulonephritis with monoclonal immunoglobulin deposits in a renal allograft
url http://www.sjkdt.org/article.asp?issn=1319-2442;year=2016;volume=27;issue=2;spage=381;epage=385;aulast=Tewari
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