Angiographic Characteristics of Cerebral Perfusion and Hemodynamics of the Bridging Artery After Surgical Treatment of Unilateral Moyamoya Disease
PurposeTo investigate the characteristics of cerebral perfusion and hemodynamics of bypass grafting in the treatment of moyamoya disease (MMD) using the iFlow color-coded flow map in comparison with magnetic resonance imaging–perfusion-weighted imaging (MRI–PWI) and computational fluid dynamic (CFD)...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2022.922482/full |
| _version_ | 1818212699263205376 |
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| author | Kun Zhang Kun Zhang Wei Ren Yu-Xue Sun Xin-Jun Wang Chao-Yue Li Zi-Liang Wang Tian-Xiao Li Bu-Lang Gao |
| author_facet | Kun Zhang Kun Zhang Wei Ren Yu-Xue Sun Xin-Jun Wang Chao-Yue Li Zi-Liang Wang Tian-Xiao Li Bu-Lang Gao |
| author_sort | Kun Zhang |
| collection | DOAJ |
| description | PurposeTo investigate the characteristics of cerebral perfusion and hemodynamics of bypass grafting in the treatment of moyamoya disease (MMD) using the iFlow color-coded flow map in comparison with magnetic resonance imaging–perfusion-weighted imaging (MRI–PWI) and computational fluid dynamic (CFD) analysis.Materials and MethodsPatients with MMD treated with bypass grafting who had undergone MRI PWI and digital subtraction angiography for iFlow color-coded map was retrospectively enrolled and CFD was performed for calculating the hemodynamic stresses around the bypass grafting.ResultsForty-five patients with unilateral MMD treated with bypass surgery were enrolled. The bypass surgery was successful in all patients, with no severe neurological complications during the periprocedural period. Followed up for 4–12 months (median 5.5), the neurological function was good in all patients. The cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT), and time to peak (TTP) were significantly (p < 0.05) improved in the middle cerebral artery distribution area on the surgical side before and after vascular bypass, and the difference of TTP (s) measured from the proximal bifurcation of common carotid artery to the confluence of sinus was also significant (p < 0.05). A significant (p < 0.05) positive correlation existed in the perfusion parameters between the iFlow blood perfusion and the MRI–PWI perfusion, with r-value for TTP of 0.765 (p < 0.01). The iFlow color-coded blood flow map showed warm color changes on the diseased side, similar to those on the contralateral side. In CFD analysis, the hemodynamic stresses were all improved, in and around the bypass grafting and distal vessels, which were beneficial to blood flow entering distal arterial branches.ConclusionThe iFlow color-coded flow map can be used to analyze cerebral perfusion after bypass grafting for MMD, similar to MRI–PWI, and CFD can be used to analyze the hemodynamics after bypass grafting, revealing improved hemodynamics to promote blood flow entering distal arteries. |
| first_indexed | 2024-12-12T05:52:33Z |
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| id | doaj.art-5496a9bcf8ad4890948658e6cc38eb0d |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-12T05:52:33Z |
| publishDate | 2022-06-01 |
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| series | Frontiers in Neuroscience |
| spelling | doaj.art-5496a9bcf8ad4890948658e6cc38eb0d2022-12-22T00:35:38ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2022-06-011610.3389/fnins.2022.922482922482Angiographic Characteristics of Cerebral Perfusion and Hemodynamics of the Bridging Artery After Surgical Treatment of Unilateral Moyamoya DiseaseKun Zhang0Kun Zhang1Wei Ren2Yu-Xue Sun3Xin-Jun Wang4Chao-Yue Li5Zi-Liang Wang6Tian-Xiao Li7Bu-Lang Gao8The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaZhengzhou University People’s Hospital, Henan Provincial People’s Hospital, Zhengzhou, ChinaZhengzhou University People’s Hospital, Henan Provincial People’s Hospital, Zhengzhou, ChinaZhengzhou University People’s Hospital, Henan Provincial People’s Hospital, Zhengzhou, ChinaThe Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaZhengzhou University People’s Hospital, Henan Provincial People’s Hospital, Zhengzhou, ChinaZhengzhou University People’s Hospital, Henan Provincial People’s Hospital, Zhengzhou, ChinaZhengzhou University People’s Hospital, Henan Provincial People’s Hospital, Zhengzhou, ChinaZhengzhou University People’s Hospital, Henan Provincial People’s Hospital, Zhengzhou, ChinaPurposeTo investigate the characteristics of cerebral perfusion and hemodynamics of bypass grafting in the treatment of moyamoya disease (MMD) using the iFlow color-coded flow map in comparison with magnetic resonance imaging–perfusion-weighted imaging (MRI–PWI) and computational fluid dynamic (CFD) analysis.Materials and MethodsPatients with MMD treated with bypass grafting who had undergone MRI PWI and digital subtraction angiography for iFlow color-coded map was retrospectively enrolled and CFD was performed for calculating the hemodynamic stresses around the bypass grafting.ResultsForty-five patients with unilateral MMD treated with bypass surgery were enrolled. The bypass surgery was successful in all patients, with no severe neurological complications during the periprocedural period. Followed up for 4–12 months (median 5.5), the neurological function was good in all patients. The cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT), and time to peak (TTP) were significantly (p < 0.05) improved in the middle cerebral artery distribution area on the surgical side before and after vascular bypass, and the difference of TTP (s) measured from the proximal bifurcation of common carotid artery to the confluence of sinus was also significant (p < 0.05). A significant (p < 0.05) positive correlation existed in the perfusion parameters between the iFlow blood perfusion and the MRI–PWI perfusion, with r-value for TTP of 0.765 (p < 0.01). The iFlow color-coded blood flow map showed warm color changes on the diseased side, similar to those on the contralateral side. In CFD analysis, the hemodynamic stresses were all improved, in and around the bypass grafting and distal vessels, which were beneficial to blood flow entering distal arterial branches.ConclusionThe iFlow color-coded flow map can be used to analyze cerebral perfusion after bypass grafting for MMD, similar to MRI–PWI, and CFD can be used to analyze the hemodynamics after bypass grafting, revealing improved hemodynamics to promote blood flow entering distal arteries.https://www.frontiersin.org/articles/10.3389/fnins.2022.922482/fullmoyamoya diseasedigital subtraction angiographycomputational fluid dynamicsbypass graftinghemodynamic stresses |
| spellingShingle | Kun Zhang Kun Zhang Wei Ren Yu-Xue Sun Xin-Jun Wang Chao-Yue Li Zi-Liang Wang Tian-Xiao Li Bu-Lang Gao Angiographic Characteristics of Cerebral Perfusion and Hemodynamics of the Bridging Artery After Surgical Treatment of Unilateral Moyamoya Disease Frontiers in Neuroscience moyamoya disease digital subtraction angiography computational fluid dynamics bypass grafting hemodynamic stresses |
| title | Angiographic Characteristics of Cerebral Perfusion and Hemodynamics of the Bridging Artery After Surgical Treatment of Unilateral Moyamoya Disease |
| title_full | Angiographic Characteristics of Cerebral Perfusion and Hemodynamics of the Bridging Artery After Surgical Treatment of Unilateral Moyamoya Disease |
| title_fullStr | Angiographic Characteristics of Cerebral Perfusion and Hemodynamics of the Bridging Artery After Surgical Treatment of Unilateral Moyamoya Disease |
| title_full_unstemmed | Angiographic Characteristics of Cerebral Perfusion and Hemodynamics of the Bridging Artery After Surgical Treatment of Unilateral Moyamoya Disease |
| title_short | Angiographic Characteristics of Cerebral Perfusion and Hemodynamics of the Bridging Artery After Surgical Treatment of Unilateral Moyamoya Disease |
| title_sort | angiographic characteristics of cerebral perfusion and hemodynamics of the bridging artery after surgical treatment of unilateral moyamoya disease |
| topic | moyamoya disease digital subtraction angiography computational fluid dynamics bypass grafting hemodynamic stresses |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2022.922482/full |
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