COVID-19 induced ARDS: immunopathology and therapeutics
The coronavirus disease-2019 (COVID-19) pandemic is a significant threat in the modern era. Clinical studies show that the most common symptom of severe COVID-19 is viral pneumonia-induced acute respiratory distress syndrome (ARDS). The underlying mechanisms by which severe respiratory disease syndr...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Open Exploration Publishing Inc.
2023-08-01
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| Series: | Exploration of Immunology |
| Subjects: | |
| Online Access: | https://www.explorationpub.com/Journals/ei/Article/1003101 |
| _version_ | 1797691840774799360 |
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| author | Sneha Das Tamanna Sharma Asha Bhardwaj Rupesh K. Srivastava |
| author_facet | Sneha Das Tamanna Sharma Asha Bhardwaj Rupesh K. Srivastava |
| author_sort | Sneha Das |
| collection | DOAJ |
| description | The coronavirus disease-2019 (COVID-19) pandemic is a significant threat in the modern era. Clinical studies show that the most common symptom of severe COVID-19 is viral pneumonia-induced acute respiratory distress syndrome (ARDS). The underlying mechanisms by which severe respiratory disease syndrome-coronavirus-2 (SARS-CoV-2) results in ARDS and how certain host factors confer an increased risk of developing severe disease remain unknown. Therefore, identifying the distinctive features of this severe and fatal disease and the therapeutic approaches to COVID-19-induced ARDS remains an immediate need to serve as a basis for best practice models of standardized ARDS treatment. This review article aims to comprehensively discuss the immunopathology of ARDS and provides an overview of the precise role of both the innate and adaptive immune system, with emphasis on the current treatment strategies being tested in the COVID-19-induced ARDS patients. This knowledge will supposedly help in revealing further mechanistic insights into understanding COVID-19-induced ARDS. |
| first_indexed | 2024-03-12T02:19:09Z |
| format | Article |
| id | doaj.art-54976a7dc7f0424e80bac982fe931571 |
| institution | Directory Open Access Journal |
| issn | 2768-6655 |
| language | English |
| last_indexed | 2024-03-12T02:19:09Z |
| publishDate | 2023-08-01 |
| publisher | Open Exploration Publishing Inc. |
| record_format | Article |
| series | Exploration of Immunology |
| spelling | doaj.art-54976a7dc7f0424e80bac982fe9315712023-09-06T06:06:58ZengOpen Exploration Publishing Inc.Exploration of Immunology2768-66552023-08-013425527510.37349/ei.2023.00101COVID-19 induced ARDS: immunopathology and therapeuticsSneha Das0https://orcid.org/0009-0008-3569-5101Tamanna Sharma1https://orcid.org/0009-0000-6966-5770Asha Bhardwaj2https://orcid.org/0000-0003-3643-8242Rupesh K. Srivastava3https://orcid.org/0000-0002-3323-0713Translational Immunology, Osteoimmunology & Immunoporosis Lab (TIOIL), Department of Biotechnology, All India Institute of Medical Sciences (AIIMS), New Delhi 110029, IndiaTranslational Immunology, Osteoimmunology & Immunoporosis Lab (TIOIL), Department of Biotechnology, All India Institute of Medical Sciences (AIIMS), New Delhi 110029, IndiaTranslational Immunology, Osteoimmunology & Immunoporosis Lab (TIOIL), Department of Biotechnology, All India Institute of Medical Sciences (AIIMS), New Delhi 110029, IndiaTranslational Immunology, Osteoimmunology & Immunoporosis Lab (TIOIL), Department of Biotechnology, All India Institute of Medical Sciences (AIIMS), New Delhi 110029, IndiaThe coronavirus disease-2019 (COVID-19) pandemic is a significant threat in the modern era. Clinical studies show that the most common symptom of severe COVID-19 is viral pneumonia-induced acute respiratory distress syndrome (ARDS). The underlying mechanisms by which severe respiratory disease syndrome-coronavirus-2 (SARS-CoV-2) results in ARDS and how certain host factors confer an increased risk of developing severe disease remain unknown. Therefore, identifying the distinctive features of this severe and fatal disease and the therapeutic approaches to COVID-19-induced ARDS remains an immediate need to serve as a basis for best practice models of standardized ARDS treatment. This review article aims to comprehensively discuss the immunopathology of ARDS and provides an overview of the precise role of both the innate and adaptive immune system, with emphasis on the current treatment strategies being tested in the COVID-19-induced ARDS patients. This knowledge will supposedly help in revealing further mechanistic insights into understanding COVID-19-induced ARDS.https://www.explorationpub.com/Journals/ei/Article/1003101coronavirus disease-2019acute respiratory distress syndromeimmunopathologyinnateadaptivetherapeutics |
| spellingShingle | Sneha Das Tamanna Sharma Asha Bhardwaj Rupesh K. Srivastava COVID-19 induced ARDS: immunopathology and therapeutics Exploration of Immunology coronavirus disease-2019 acute respiratory distress syndrome immunopathology innate adaptive therapeutics |
| title | COVID-19 induced ARDS: immunopathology and therapeutics |
| title_full | COVID-19 induced ARDS: immunopathology and therapeutics |
| title_fullStr | COVID-19 induced ARDS: immunopathology and therapeutics |
| title_full_unstemmed | COVID-19 induced ARDS: immunopathology and therapeutics |
| title_short | COVID-19 induced ARDS: immunopathology and therapeutics |
| title_sort | covid 19 induced ards immunopathology and therapeutics |
| topic | coronavirus disease-2019 acute respiratory distress syndrome immunopathology innate adaptive therapeutics |
| url | https://www.explorationpub.com/Journals/ei/Article/1003101 |
| work_keys_str_mv | AT snehadas covid19inducedardsimmunopathologyandtherapeutics AT tamannasharma covid19inducedardsimmunopathologyandtherapeutics AT ashabhardwaj covid19inducedardsimmunopathologyandtherapeutics AT rupeshksrivastava covid19inducedardsimmunopathologyandtherapeutics |