Pulmonary Vascular Remodeling in Pulmonary Hypertension
Pulmonary vascular remodeling is the critical structural alteration and pathological feature in pulmonary hypertension (PH) and involves changes in the intima, media and adventitia. Pulmonary vascular remodeling consists of the proliferation and phenotypic transformation of pulmonary artery endothel...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/13/2/366 |
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| author | Zhuangzhuang Jia Shuai Wang Haifeng Yan Yawen Cao Xuan Zhang Lin Wang Zeyu Zhang Shanshan Lin Xianliang Wang Jingyuan Mao |
| author_facet | Zhuangzhuang Jia Shuai Wang Haifeng Yan Yawen Cao Xuan Zhang Lin Wang Zeyu Zhang Shanshan Lin Xianliang Wang Jingyuan Mao |
| author_sort | Zhuangzhuang Jia |
| collection | DOAJ |
| description | Pulmonary vascular remodeling is the critical structural alteration and pathological feature in pulmonary hypertension (PH) and involves changes in the intima, media and adventitia. Pulmonary vascular remodeling consists of the proliferation and phenotypic transformation of pulmonary artery endothelial cells (PAECs) and pulmonary artery smooth muscle cells (PASMCs) of the middle membranous pulmonary artery, as well as complex interactions involving external layer pulmonary artery fibroblasts (PAFs) and extracellular matrix (ECM). Inflammatory mechanisms, apoptosis and other factors in the vascular wall are influenced by different mechanisms that likely act in concert to drive disease progression. This article reviews these pathological changes and highlights some pathogenetic mechanisms involved in the remodeling process. |
| first_indexed | 2024-03-11T08:34:28Z |
| format | Article |
| id | doaj.art-549aa2df4d77453ea67e570a26a0950b |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-11T08:34:28Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-549aa2df4d77453ea67e570a26a0950b2023-11-16T21:34:25ZengMDPI AGJournal of Personalized Medicine2075-44262023-02-0113236610.3390/jpm13020366Pulmonary Vascular Remodeling in Pulmonary HypertensionZhuangzhuang Jia0Shuai Wang1Haifeng Yan2Yawen Cao3Xuan Zhang4Lin Wang5Zeyu Zhang6Shanshan Lin7Xianliang Wang8Jingyuan Mao9Department of Cardiovascular Diseases, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, ChinaDepartment of Cardiovascular Diseases, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, ChinaDepartment of Cardiovascular Diseases, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450000, ChinaDepartment of Cardiovascular Diseases, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, ChinaDepartment of Cardiovascular Diseases, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, ChinaDepartment of Cardiovascular Diseases, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, ChinaDepartment of Cardiovascular Diseases, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, ChinaDepartment of Cardiovascular Diseases, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, ChinaDepartment of Cardiovascular Diseases, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, ChinaDepartment of Cardiovascular Diseases, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, ChinaPulmonary vascular remodeling is the critical structural alteration and pathological feature in pulmonary hypertension (PH) and involves changes in the intima, media and adventitia. Pulmonary vascular remodeling consists of the proliferation and phenotypic transformation of pulmonary artery endothelial cells (PAECs) and pulmonary artery smooth muscle cells (PASMCs) of the middle membranous pulmonary artery, as well as complex interactions involving external layer pulmonary artery fibroblasts (PAFs) and extracellular matrix (ECM). Inflammatory mechanisms, apoptosis and other factors in the vascular wall are influenced by different mechanisms that likely act in concert to drive disease progression. This article reviews these pathological changes and highlights some pathogenetic mechanisms involved in the remodeling process.https://www.mdpi.com/2075-4426/13/2/366pulmonary hypertensionpulmonary vascular remodelingintimamediaadventitiaextracellular matrix |
| spellingShingle | Zhuangzhuang Jia Shuai Wang Haifeng Yan Yawen Cao Xuan Zhang Lin Wang Zeyu Zhang Shanshan Lin Xianliang Wang Jingyuan Mao Pulmonary Vascular Remodeling in Pulmonary Hypertension Journal of Personalized Medicine pulmonary hypertension pulmonary vascular remodeling intima media adventitia extracellular matrix |
| title | Pulmonary Vascular Remodeling in Pulmonary Hypertension |
| title_full | Pulmonary Vascular Remodeling in Pulmonary Hypertension |
| title_fullStr | Pulmonary Vascular Remodeling in Pulmonary Hypertension |
| title_full_unstemmed | Pulmonary Vascular Remodeling in Pulmonary Hypertension |
| title_short | Pulmonary Vascular Remodeling in Pulmonary Hypertension |
| title_sort | pulmonary vascular remodeling in pulmonary hypertension |
| topic | pulmonary hypertension pulmonary vascular remodeling intima media adventitia extracellular matrix |
| url | https://www.mdpi.com/2075-4426/13/2/366 |
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