GPR15 in colon cancer development and anti-tumor immune responses

GPR15 in colon cancer development and anti-tumor immune responses

IntroductionThe chemoattractant receptor, G protein-coupled receptor 15 (GPR15), promotes colon homing of T cells in health and colitis. GPR15 function in colon cancer is largely unexplored, motivating our current studies.MethodsIn human study, immune cells were isolated from tumor tissues and healt...

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Bibliographic Details
Main Authors: Hong Namkoong, Bomi Lee, Gayathri Swaminathan, Seong-Joon Koh, Stephan Rogalla, Maria D. Paraskevopoulou, Jay Tang, David Mikhail, Laren S. Becker, Aida Habtezion
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Oncology
Subjects:
GPR15
GPR15L
colon cancer
T cells
tumor-microenvironment
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1254307/full

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