Effects and mechanisms of auricular electroacupuncture on gastric hypersensitivity in a rodent model of functional dyspepsia.
BACKGROUND:Functional dyspepsia (FD) is a common functional gastrointestinal disease, and abdominal pain is one of the main symptoms. The aim of this study was to explore the effects and mechanisms of auricular electro-acupuncture (AEA) on gastric hypersensitivity in a rodent model of FD. METHODS:Te...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2017-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5370122?pdf=render |
| _version_ | 1818306503226949632 |
|---|---|
| author | Jingzhu Zhou Shiying Li Yinping Wang Yong Lei Robert D Foreman Jieyun Yin Jiande D Z Chen |
| author_facet | Jingzhu Zhou Shiying Li Yinping Wang Yong Lei Robert D Foreman Jieyun Yin Jiande D Z Chen |
| author_sort | Jingzhu Zhou |
| collection | DOAJ |
| description | BACKGROUND:Functional dyspepsia (FD) is a common functional gastrointestinal disease, and abdominal pain is one of the main symptoms. The aim of this study was to explore the effects and mechanisms of auricular electro-acupuncture (AEA) on gastric hypersensitivity in a rodent model of FD. METHODS:Ten-day-old pups were gavaged with 0.2 ml of 0.1% iodoacetamide daily for 6 days. AEA at the "stomach" point with different parameters or sham-EA was performed on 8-week-old animals. Gastric sensitivity to gastric distention was measured under different conditions. Autonomic functions were assessed from the spectral analysis of heart rate variability (HRV) derived from the electrocardiogram. Naloxone was injected intraperitoneally before AEA to explore the opioid mechanism. Gastric emptying was measured at the end of the study. RESULTS:1) Gastric sensitivity to gastric distention was higher in the FD rats. AEA with parameters of 0.1s on, 0.4s off, 100Hz, 0.3ms and 0.4-0.5mA, but not other parameters or sham-EA, decreased gastric hypersensitivity in the FD rats. Naloxone did not block the effect of AEA. 2) Lower vagal activity and higher sympathovagal ratio were noted in the FD rats, compared with the controls. AEA increased vagal activity and improved sympathovagal imbalance. CONCLUSIONS:AEA ameliorates gastric hypersensitivity in FD rats and this effect may be attributed to the improvement of sympathovagal balance. |
| first_indexed | 2024-12-13T06:43:31Z |
| format | Article |
| id | doaj.art-549be9fedf9d4bd2840c67460c667919 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T06:43:31Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-549be9fedf9d4bd2840c67460c6679192022-12-21T23:56:21ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01123e017456810.1371/journal.pone.0174568Effects and mechanisms of auricular electroacupuncture on gastric hypersensitivity in a rodent model of functional dyspepsia.Jingzhu ZhouShiying LiYinping WangYong LeiRobert D ForemanJieyun YinJiande D Z ChenBACKGROUND:Functional dyspepsia (FD) is a common functional gastrointestinal disease, and abdominal pain is one of the main symptoms. The aim of this study was to explore the effects and mechanisms of auricular electro-acupuncture (AEA) on gastric hypersensitivity in a rodent model of FD. METHODS:Ten-day-old pups were gavaged with 0.2 ml of 0.1% iodoacetamide daily for 6 days. AEA at the "stomach" point with different parameters or sham-EA was performed on 8-week-old animals. Gastric sensitivity to gastric distention was measured under different conditions. Autonomic functions were assessed from the spectral analysis of heart rate variability (HRV) derived from the electrocardiogram. Naloxone was injected intraperitoneally before AEA to explore the opioid mechanism. Gastric emptying was measured at the end of the study. RESULTS:1) Gastric sensitivity to gastric distention was higher in the FD rats. AEA with parameters of 0.1s on, 0.4s off, 100Hz, 0.3ms and 0.4-0.5mA, but not other parameters or sham-EA, decreased gastric hypersensitivity in the FD rats. Naloxone did not block the effect of AEA. 2) Lower vagal activity and higher sympathovagal ratio were noted in the FD rats, compared with the controls. AEA increased vagal activity and improved sympathovagal imbalance. CONCLUSIONS:AEA ameliorates gastric hypersensitivity in FD rats and this effect may be attributed to the improvement of sympathovagal balance.http://europepmc.org/articles/PMC5370122?pdf=render |
| spellingShingle | Jingzhu Zhou Shiying Li Yinping Wang Yong Lei Robert D Foreman Jieyun Yin Jiande D Z Chen Effects and mechanisms of auricular electroacupuncture on gastric hypersensitivity in a rodent model of functional dyspepsia. PLoS ONE |
| title | Effects and mechanisms of auricular electroacupuncture on gastric hypersensitivity in a rodent model of functional dyspepsia. |
| title_full | Effects and mechanisms of auricular electroacupuncture on gastric hypersensitivity in a rodent model of functional dyspepsia. |
| title_fullStr | Effects and mechanisms of auricular electroacupuncture on gastric hypersensitivity in a rodent model of functional dyspepsia. |
| title_full_unstemmed | Effects and mechanisms of auricular electroacupuncture on gastric hypersensitivity in a rodent model of functional dyspepsia. |
| title_short | Effects and mechanisms of auricular electroacupuncture on gastric hypersensitivity in a rodent model of functional dyspepsia. |
| title_sort | effects and mechanisms of auricular electroacupuncture on gastric hypersensitivity in a rodent model of functional dyspepsia |
| url | http://europepmc.org/articles/PMC5370122?pdf=render |
| work_keys_str_mv | AT jingzhuzhou effectsandmechanismsofauricularelectroacupunctureongastrichypersensitivityinarodentmodeloffunctionaldyspepsia AT shiyingli effectsandmechanismsofauricularelectroacupunctureongastrichypersensitivityinarodentmodeloffunctionaldyspepsia AT yinpingwang effectsandmechanismsofauricularelectroacupunctureongastrichypersensitivityinarodentmodeloffunctionaldyspepsia AT yonglei effectsandmechanismsofauricularelectroacupunctureongastrichypersensitivityinarodentmodeloffunctionaldyspepsia AT robertdforeman effectsandmechanismsofauricularelectroacupunctureongastrichypersensitivityinarodentmodeloffunctionaldyspepsia AT jieyunyin effectsandmechanismsofauricularelectroacupunctureongastrichypersensitivityinarodentmodeloffunctionaldyspepsia AT jiandedzchen effectsandmechanismsofauricularelectroacupunctureongastrichypersensitivityinarodentmodeloffunctionaldyspepsia |