Short‐term evaluation of renal markers in overweight adult cats
Abstract Background Obesity has been proposed as an independently risk factor for chronic kidney disease (CKD) in people, but its role in feline kidney function is unknown. Objective Obesity has been proposed as an independent risk factor for chronic kidney disease (CKD) in people, but its role in f...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-03-01
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| Series: | Veterinary Medicine and Science |
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| Online Access: | https://doi.org/10.1002/vms3.1021 |
| _version_ | 1797866293033959424 |
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| author | Laura Pérez‐López Mauro Boronat Carlos Melián Angelo Santana Yeray Brito‐Casillas Ana M. Wägner |
| author_facet | Laura Pérez‐López Mauro Boronat Carlos Melián Angelo Santana Yeray Brito‐Casillas Ana M. Wägner |
| author_sort | Laura Pérez‐López |
| collection | DOAJ |
| description | Abstract Background Obesity has been proposed as an independently risk factor for chronic kidney disease (CKD) in people, but its role in feline kidney function is unknown. Objective Obesity has been proposed as an independent risk factor for chronic kidney disease (CKD) in people, but its role in feline kidney function is unknown. This study prospectively evaluated the effect of overweight on the concentration of symmetric dimethylarginine (SDMA) and creatinine in a cohort of healthy cats. Methods Forty healthy adult cats were included, 14 with a body condition score (BCS) = 5 and 26 with a BCS > 5. Cats were examined every 6 months, for up to 12 months. SDMA and creatinine were measured at baseline and follow‐up. Results No effect was found for time of follow‐up (p = 0.072), overweight (p = 0.9442) or their interaction (p = 0.902) on SDMA, though a significant effect was found for age (p < 0.001) [older cats showing higher SDMA] and sex (p = 0.007) [male cats showing higher SDMA]. Regarding creatinine, no effect for time (p = 0.671), age (p = 0.061), overweight (p = 0.319) or the latter's interaction (p = 0.386) were found. Conclusions In the short term, markers of renal function did not show an association with overweight. The role of obesity in feline kidney function still warrants further evaluation. |
| first_indexed | 2024-04-09T23:21:41Z |
| format | Article |
| id | doaj.art-549c0c7d8c1b48d19af1cf6e5c057443 |
| institution | Directory Open Access Journal |
| issn | 2053-1095 |
| language | English |
| last_indexed | 2024-04-09T23:21:41Z |
| publishDate | 2023-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Veterinary Medicine and Science |
| spelling | doaj.art-549c0c7d8c1b48d19af1cf6e5c0574432023-03-21T15:53:53ZengWileyVeterinary Medicine and Science2053-10952023-03-019257257810.1002/vms3.1021Short‐term evaluation of renal markers in overweight adult catsLaura Pérez‐López0Mauro Boronat1Carlos Melián2Angelo Santana3Yeray Brito‐Casillas4Ana M. Wägner5Instituto Universitario de Investigaciones Biomédicas y Sanitarias de la Universidad de Las Palmas de Gran Canaria Las Palmas de Gran CanariaCanary Islands SpainInstituto Universitario de Investigaciones Biomédicas y Sanitarias de la Universidad de Las Palmas de Gran Canaria Las Palmas de Gran CanariaCanary Islands SpainInstituto Universitario de Investigaciones Biomédicas y Sanitarias de la Universidad de Las Palmas de Gran Canaria Las Palmas de Gran CanariaCanary Islands SpainDepartment of Mathematics and Statistics University of Las Palmas de Gran Canaria Las Palmas de Gran Canaria Canary Islands SpainInstituto Universitario de Investigaciones Biomédicas y Sanitarias de la Universidad de Las Palmas de Gran Canaria Las Palmas de Gran CanariaCanary Islands SpainInstituto Universitario de Investigaciones Biomédicas y Sanitarias de la Universidad de Las Palmas de Gran Canaria Las Palmas de Gran CanariaCanary Islands SpainAbstract Background Obesity has been proposed as an independently risk factor for chronic kidney disease (CKD) in people, but its role in feline kidney function is unknown. Objective Obesity has been proposed as an independent risk factor for chronic kidney disease (CKD) in people, but its role in feline kidney function is unknown. This study prospectively evaluated the effect of overweight on the concentration of symmetric dimethylarginine (SDMA) and creatinine in a cohort of healthy cats. Methods Forty healthy adult cats were included, 14 with a body condition score (BCS) = 5 and 26 with a BCS > 5. Cats were examined every 6 months, for up to 12 months. SDMA and creatinine were measured at baseline and follow‐up. Results No effect was found for time of follow‐up (p = 0.072), overweight (p = 0.9442) or their interaction (p = 0.902) on SDMA, though a significant effect was found for age (p < 0.001) [older cats showing higher SDMA] and sex (p = 0.007) [male cats showing higher SDMA]. Regarding creatinine, no effect for time (p = 0.671), age (p = 0.061), overweight (p = 0.319) or the latter's interaction (p = 0.386) were found. Conclusions In the short term, markers of renal function did not show an association with overweight. The role of obesity in feline kidney function still warrants further evaluation.https://doi.org/10.1002/vms3.1021chronic kidney diseasecreatinineobesitysymmetric dimethylarginine |
| spellingShingle | Laura Pérez‐López Mauro Boronat Carlos Melián Angelo Santana Yeray Brito‐Casillas Ana M. Wägner Short‐term evaluation of renal markers in overweight adult cats Veterinary Medicine and Science chronic kidney disease creatinine obesity symmetric dimethylarginine |
| title | Short‐term evaluation of renal markers in overweight adult cats |
| title_full | Short‐term evaluation of renal markers in overweight adult cats |
| title_fullStr | Short‐term evaluation of renal markers in overweight adult cats |
| title_full_unstemmed | Short‐term evaluation of renal markers in overweight adult cats |
| title_short | Short‐term evaluation of renal markers in overweight adult cats |
| title_sort | short term evaluation of renal markers in overweight adult cats |
| topic | chronic kidney disease creatinine obesity symmetric dimethylarginine |
| url | https://doi.org/10.1002/vms3.1021 |
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