Cistanche deserticola improves postmenopausal osteoporosis through gut microbiota and short-chain fatty acids
The decrease of bone mineral density, osteopenia, and changes in bone tissue structure in postmenopausal osteoporosis (PMO) are related to the disturbance of the body's microbiota, but the specific mechanism is still unclear. Cistanche deserticola Y. C. Ma. (Orobanchaceae, CD) is a medicinal an...
| Glavni autori: | , , , , , , |
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| Format: | Članak |
| Jezik: | English |
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Elsevier
2024-01-01
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| Serija: | Journal of Functional Foods |
| Teme: | |
| Online pristup: | http://www.sciencedirect.com/science/article/pii/S175646462300525X |
| _version_ | 1827382545184980992 |
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| author | Fang Yang Chang Liu Xiangyi Lu Shuowen Liu Yuxin Zhang Yang Yu Yongling Long |
| author_facet | Fang Yang Chang Liu Xiangyi Lu Shuowen Liu Yuxin Zhang Yang Yu Yongling Long |
| author_sort | Fang Yang |
| collection | DOAJ |
| description | The decrease of bone mineral density, osteopenia, and changes in bone tissue structure in postmenopausal osteoporosis (PMO) are related to the disturbance of the body's microbiota, but the specific mechanism is still unclear. Cistanche deserticola Y. C. Ma. (Orobanchaceae, CD) is a medicinal and dietary herb widely used in China, and studies have been conducted to prove its effectiveness in the treatment of postmenopausal osteoporosis. This study aims to investigate the potential mechanism of cell-broken decoction pieces of Cistanche deserticola (CDC) in regulating gut microbiota and gut microbial metabolites to improve postmenopausal osteoporosis. The results show that CDC improved gut microbiota disorders, and promoted the production of beneficial bacteria of Firmicutes, Roseburia, and Oscillibacter that mainly produce SCFAs, and increased intestinal barrier function, thus protecting OVX mice from bone loss, which provides a reference for the clinical application of CDC in the prevention and treatment of PMO. |
| first_indexed | 2024-03-08T14:22:08Z |
| format | Article |
| id | doaj.art-549f7ad5ef8b4a1fa1d1170693a1df5b |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-03-08T14:22:08Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-549f7ad5ef8b4a1fa1d1170693a1df5b2024-01-14T05:37:11ZengElsevierJournal of Functional Foods1756-46462024-01-01112105925Cistanche deserticola improves postmenopausal osteoporosis through gut microbiota and short-chain fatty acidsFang Yang0Chang Liu1Xiangyi Lu2Shuowen Liu3Yuxin Zhang4Yang Yu5Yongling Long6School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, ChinaGuangdong Provincial Engineering Research Center for Quality and Safety of Traditional Chinese Medicine, Guangdong Provincial Key Laboratory of Chemical Measurement and Emergency Test Technology, Institute of Analysis, Guangdong Academy of Sciences(China National Analytical Center, Guangzhou) Guangzhou, Guangdong 510070, ChinaSchool of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, ChinaSchool of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, ChinaSchool of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, ChinaSchool of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, China; Corresponding authors at: Room C306, Pharmaceutical Building, Guangzhou University of Chinese Medicine, No. 232 Waihuan East Road, Panyu District, Guangzhou City, Guang Dong Province, China.School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, China; Corresponding authors at: Room C306, Pharmaceutical Building, Guangzhou University of Chinese Medicine, No. 232 Waihuan East Road, Panyu District, Guangzhou City, Guang Dong Province, China.The decrease of bone mineral density, osteopenia, and changes in bone tissue structure in postmenopausal osteoporosis (PMO) are related to the disturbance of the body's microbiota, but the specific mechanism is still unclear. Cistanche deserticola Y. C. Ma. (Orobanchaceae, CD) is a medicinal and dietary herb widely used in China, and studies have been conducted to prove its effectiveness in the treatment of postmenopausal osteoporosis. This study aims to investigate the potential mechanism of cell-broken decoction pieces of Cistanche deserticola (CDC) in regulating gut microbiota and gut microbial metabolites to improve postmenopausal osteoporosis. The results show that CDC improved gut microbiota disorders, and promoted the production of beneficial bacteria of Firmicutes, Roseburia, and Oscillibacter that mainly produce SCFAs, and increased intestinal barrier function, thus protecting OVX mice from bone loss, which provides a reference for the clinical application of CDC in the prevention and treatment of PMO.http://www.sciencedirect.com/science/article/pii/S175646462300525XPostmenopausal osteoporosisCistanche deserticolaCell-broken decoction pieces of Cistanche deserticolaGut microbiotaShort-chain fatty acids |
| spellingShingle | Fang Yang Chang Liu Xiangyi Lu Shuowen Liu Yuxin Zhang Yang Yu Yongling Long Cistanche deserticola improves postmenopausal osteoporosis through gut microbiota and short-chain fatty acids Journal of Functional Foods Postmenopausal osteoporosis Cistanche deserticola Cell-broken decoction pieces of Cistanche deserticola Gut microbiota Short-chain fatty acids |
| title | Cistanche deserticola improves postmenopausal osteoporosis through gut microbiota and short-chain fatty acids |
| title_full | Cistanche deserticola improves postmenopausal osteoporosis through gut microbiota and short-chain fatty acids |
| title_fullStr | Cistanche deserticola improves postmenopausal osteoporosis through gut microbiota and short-chain fatty acids |
| title_full_unstemmed | Cistanche deserticola improves postmenopausal osteoporosis through gut microbiota and short-chain fatty acids |
| title_short | Cistanche deserticola improves postmenopausal osteoporosis through gut microbiota and short-chain fatty acids |
| title_sort | cistanche deserticola improves postmenopausal osteoporosis through gut microbiota and short chain fatty acids |
| topic | Postmenopausal osteoporosis Cistanche deserticola Cell-broken decoction pieces of Cistanche deserticola Gut microbiota Short-chain fatty acids |
| url | http://www.sciencedirect.com/science/article/pii/S175646462300525X |
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