PET measurement of cyclooxygenase-2 using a novel radioligand: upregulation in primate neuroinflammation and first-in-human study

PET measurement of cyclooxygenase-2 using a novel radioligand: upregulation in primate neuroinflammation and first-in-human study

Abstract Background Cyclooxygenase-2 (COX-2), which is rapidly upregulated by inflammation, is a key enzyme catalyzing the rate-limiting step in the synthesis of several inflammatory prostanoids. Successful positron emission tomography (PET) radioligand imaging of COX-2 in vivo could be a potentiall...

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Bibliographic Details
Main Authors: Stal Shrestha, Min-Jeong Kim, Mark Eldridge, Michael L. Lehmann, Michael Frankland, Jeih-San Liow, Zu-Xi Yu, Michelle Cortes-Salva, Sanjay Telu, Ioline D. Henter, Evan Gallagher, Jae-Hoon Lee, J. Megan Fredericks, Chelsie Poffenberger, George Tye, Yanira Ruiz-Perdomo, Fernanda Juarez Anaya, Jose A. Montero Santamaria, Robert L. Gladding, Sami S. Zoghbi, Masahiro Fujita, James D. Katz, Victor W. Pike, Robert B. Innis
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Journal of Neuroinflammation
Subjects:
Cyclooxygenase 2
Cyclooxygenase 1
Positron emission tomography
Inflammation
Lipopolysaccharide
Rheumatoid arthritis
Online Access:http://link.springer.com/article/10.1186/s12974-020-01804-6

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