The Effects of the Preconception Endurance Exercise Training and Voluntary Exercise Activity during Pregnancy in C57BL/6 Mice on Lipid Profile of the Adult Offsprings
Abstract Background: The aim of this study was to determine the effect of preconception endurance exercise training with voluntary exercise activity during pregnancy in mother mice on lipid profile in adult offsprings. Materials and Methods: Twenty four C57BL/6 female mice were randomly divided in...
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| Format: | Article |
| Language: | fas |
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Arak Medical University
2016-05-01
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| Series: | Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk |
| Subjects: | |
| Online Access: | http://amuj.arakmu.ac.ir/article-1-4041-en.pdf |
| _version_ | 1818955864443191296 |
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| author | Abbasali Gaeini Leila Shafiei Neek Siroos Choobineh Mohammadreza Baghban Eslaminejad Sadegh Satarifard Seyedeh Neda Mousavi |
| author_facet | Abbasali Gaeini Leila Shafiei Neek Siroos Choobineh Mohammadreza Baghban Eslaminejad Sadegh Satarifard Seyedeh Neda Mousavi |
| author_sort | Abbasali Gaeini |
| collection | DOAJ |
| description | Abstract
Background: The aim of this study was to determine the effect of preconception endurance exercise training with voluntary exercise activity during pregnancy in mother mice on lipid profile in adult offsprings.
Materials and Methods: Twenty four C57BL/6 female mice were randomly divided into four subgroups: trained in preconception period and exercised during pregnancy (TE)(20.3±1.02g); trained in preconception periods but unexercised during pregnancy (TC)(21.58±0.4g); untrained in preconception periods but exercised during pregnancy (CE)(21.02±0.23g); untrained and unexercised (CC)(19.23±0.45g). Trained mice were subjected to a protocol of moderate endurance exercise training over a period of 4 weeks for 5 days before pregnancy. The fasting blood samples were collected from adult mice(8 weeks old) and serum levels of glucose and lipid profile were measured. Data were analyzed using two way ANOVA and Tukey’s post hoc test.
Results: The Glucose test results in offspring showed that there was a significant interaction between group and sex and group main effect (p<0.001) Glucose levels of male offspring were significantly lower in TC and TE groups. Results on LDL also showed that the sex main effect was significant (p<0.001), and LDL levels of male born to TE and TC dams lower than in female offspring.
Conclusion: Improving the mother's physical fitness by providing regular endurance training in the preconception period and maintaining it by exercise activty throughout pregnancy may have potential for eliciting positive changes in lipid profile of offspring, specially males. |
| first_indexed | 2024-12-20T10:44:50Z |
| format | Article |
| id | doaj.art-549fed7ebc5244938463c0201399313e |
| institution | Directory Open Access Journal |
| issn | 1735-5338 2008-644X |
| language | fas |
| last_indexed | 2024-12-20T10:44:50Z |
| publishDate | 2016-05-01 |
| publisher | Arak Medical University |
| record_format | Article |
| series | Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk |
| spelling | doaj.art-549fed7ebc5244938463c0201399313e2022-12-21T19:43:27ZfasArak Medical UniversityMajallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk1735-53382008-644X2016-05-011926879The Effects of the Preconception Endurance Exercise Training and Voluntary Exercise Activity during Pregnancy in C57BL/6 Mice on Lipid Profile of the Adult OffspringsAbbasali Gaeini0Leila Shafiei Neek1Siroos Choobineh2Mohammadreza Baghban Eslaminejad3Sadegh Satarifard4Seyedeh Neda Mousavi5Professor, Department of Sport Physiology, University of Tehran, Tehran, Iran.PhD Student, Department of Sport Physiology, University of Tehran, Tehran, Iran.Assisstant Professor, Department of Sport Physiology, University of Tehran, Tehran, Iran.Professor, Department of Stem Cells and Developmental Biology, Cell Sciences Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.PhD Student, Department of Sport Physiology, University of Tehran, Tehran, Iran.PhD Student, Department of Cellular and Molecular Nutrition, Tehran University of Medical Sciences, Tehran, Iran. Abstract Background: The aim of this study was to determine the effect of preconception endurance exercise training with voluntary exercise activity during pregnancy in mother mice on lipid profile in adult offsprings. Materials and Methods: Twenty four C57BL/6 female mice were randomly divided into four subgroups: trained in preconception period and exercised during pregnancy (TE)(20.3±1.02g); trained in preconception periods but unexercised during pregnancy (TC)(21.58±0.4g); untrained in preconception periods but exercised during pregnancy (CE)(21.02±0.23g); untrained and unexercised (CC)(19.23±0.45g). Trained mice were subjected to a protocol of moderate endurance exercise training over a period of 4 weeks for 5 days before pregnancy. The fasting blood samples were collected from adult mice(8 weeks old) and serum levels of glucose and lipid profile were measured. Data were analyzed using two way ANOVA and Tukey’s post hoc test. Results: The Glucose test results in offspring showed that there was a significant interaction between group and sex and group main effect (p<0.001) Glucose levels of male offspring were significantly lower in TC and TE groups. Results on LDL also showed that the sex main effect was significant (p<0.001), and LDL levels of male born to TE and TC dams lower than in female offspring. Conclusion: Improving the mother's physical fitness by providing regular endurance training in the preconception period and maintaining it by exercise activty throughout pregnancy may have potential for eliciting positive changes in lipid profile of offspring, specially males.http://amuj.arakmu.ac.ir/article-1-4041-en.pdfExercise activityPhysical fitnessPregnancyAdult offspring |
| spellingShingle | Abbasali Gaeini Leila Shafiei Neek Siroos Choobineh Mohammadreza Baghban Eslaminejad Sadegh Satarifard Seyedeh Neda Mousavi The Effects of the Preconception Endurance Exercise Training and Voluntary Exercise Activity during Pregnancy in C57BL/6 Mice on Lipid Profile of the Adult Offsprings Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk Exercise activity Physical fitness Pregnancy Adult offspring |
| title | The Effects of the Preconception Endurance Exercise Training and Voluntary Exercise Activity during Pregnancy in C57BL/6 Mice on Lipid Profile of the Adult Offsprings |
| title_full | The Effects of the Preconception Endurance Exercise Training and Voluntary Exercise Activity during Pregnancy in C57BL/6 Mice on Lipid Profile of the Adult Offsprings |
| title_fullStr | The Effects of the Preconception Endurance Exercise Training and Voluntary Exercise Activity during Pregnancy in C57BL/6 Mice on Lipid Profile of the Adult Offsprings |
| title_full_unstemmed | The Effects of the Preconception Endurance Exercise Training and Voluntary Exercise Activity during Pregnancy in C57BL/6 Mice on Lipid Profile of the Adult Offsprings |
| title_short | The Effects of the Preconception Endurance Exercise Training and Voluntary Exercise Activity during Pregnancy in C57BL/6 Mice on Lipid Profile of the Adult Offsprings |
| title_sort | effects of the preconception endurance exercise training and voluntary exercise activity during pregnancy in c57bl 6 mice on lipid profile of the adult offsprings |
| topic | Exercise activity Physical fitness Pregnancy Adult offspring |
| url | http://amuj.arakmu.ac.ir/article-1-4041-en.pdf |
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