Qingkailing injection for the treatment of acute upper respiratory infection in children: a systematic review and meta-analysis
Objective: To systematically evaluate the clinical efficacy and safety of Qingkailing (QKL) injection for pediatric acute upper respiratory infection (AURI). Methods: We searched for randomized controlled trials (RCTs) of pediatric AURI treated by QKL and western medicine (WM) in the China National...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017-07-01
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| Series: | Journal of Traditional Chinese Medical Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2095754816300618 |
| _version_ | 1797727423621496832 |
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| author | Jiarui Wu Dan Zhang Yutong Wang Xiaomeng Zhang Shi Liu Bing Zhang |
| author_facet | Jiarui Wu Dan Zhang Yutong Wang Xiaomeng Zhang Shi Liu Bing Zhang |
| author_sort | Jiarui Wu |
| collection | DOAJ |
| description | Objective: To systematically evaluate the clinical efficacy and safety of Qingkailing (QKL) injection for pediatric acute upper respiratory infection (AURI).
Methods: We searched for randomized controlled trials (RCTs) of pediatric AURI treated by QKL and western medicine (WM) in the China National Knowledge Infrastructure Database, China Science and Technology Journal Database, Wanfang, Chinese Biomedical Literature Database, PubMed and Cochrane Library from inception to August, 2016. Two reviewers independently retrieved the RCTs and extracted information. The Cochrane Collaboration Risk of Bias Assessment Tool was used to evaluate the methodological quality of RCTs. The data were meta-analyzed by RevMan 5.3 software.
Results: Ultimately, 21 RCTs that involved 2364 participants were included, and the quality of RCTs was generally poor. According to the meta-analysis, the combined use of QKL and WM for treating AURI can be effective, with a higher total effective rate, less defervescence time and less recovery time of tonsil and throat inflammation. Twenty-five adverse drug reactions (ADRs) were reported in three RCTs, but there were no serious ADRs.
Conclusion: The combination of QKL and WM for treating pediatric AURI can result in better effects, but no definitive conclusions can be made regarding its safety. More rigorous RCTs are needed to support the clinical application of QKL. |
| first_indexed | 2024-03-12T10:59:29Z |
| format | Article |
| id | doaj.art-54a280c470d44e11a6a45250d9f87912 |
| institution | Directory Open Access Journal |
| issn | 2095-7548 |
| language | English |
| last_indexed | 2024-03-12T10:59:29Z |
| publishDate | 2017-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Traditional Chinese Medical Sciences |
| spelling | doaj.art-54a280c470d44e11a6a45250d9f879122023-09-02T05:55:23ZengElsevierJournal of Traditional Chinese Medical Sciences2095-75482017-07-014324525310.1016/j.jtcms.2017.07.014Qingkailing injection for the treatment of acute upper respiratory infection in children: a systematic review and meta-analysisJiarui WuDan ZhangYutong WangXiaomeng ZhangShi LiuBing ZhangObjective: To systematically evaluate the clinical efficacy and safety of Qingkailing (QKL) injection for pediatric acute upper respiratory infection (AURI). Methods: We searched for randomized controlled trials (RCTs) of pediatric AURI treated by QKL and western medicine (WM) in the China National Knowledge Infrastructure Database, China Science and Technology Journal Database, Wanfang, Chinese Biomedical Literature Database, PubMed and Cochrane Library from inception to August, 2016. Two reviewers independently retrieved the RCTs and extracted information. The Cochrane Collaboration Risk of Bias Assessment Tool was used to evaluate the methodological quality of RCTs. The data were meta-analyzed by RevMan 5.3 software. Results: Ultimately, 21 RCTs that involved 2364 participants were included, and the quality of RCTs was generally poor. According to the meta-analysis, the combined use of QKL and WM for treating AURI can be effective, with a higher total effective rate, less defervescence time and less recovery time of tonsil and throat inflammation. Twenty-five adverse drug reactions (ADRs) were reported in three RCTs, but there were no serious ADRs. Conclusion: The combination of QKL and WM for treating pediatric AURI can result in better effects, but no definitive conclusions can be made regarding its safety. More rigorous RCTs are needed to support the clinical application of QKL.http://www.sciencedirect.com/science/article/pii/S2095754816300618Qingkailing injectionChildrenAcute upper respiratory infectionRandomized controlled trialsMeta-analysis |
| spellingShingle | Jiarui Wu Dan Zhang Yutong Wang Xiaomeng Zhang Shi Liu Bing Zhang Qingkailing injection for the treatment of acute upper respiratory infection in children: a systematic review and meta-analysis Journal of Traditional Chinese Medical Sciences Qingkailing injection Children Acute upper respiratory infection Randomized controlled trials Meta-analysis |
| title | Qingkailing injection for the treatment of acute upper respiratory infection in children: a systematic review and meta-analysis |
| title_full | Qingkailing injection for the treatment of acute upper respiratory infection in children: a systematic review and meta-analysis |
| title_fullStr | Qingkailing injection for the treatment of acute upper respiratory infection in children: a systematic review and meta-analysis |
| title_full_unstemmed | Qingkailing injection for the treatment of acute upper respiratory infection in children: a systematic review and meta-analysis |
| title_short | Qingkailing injection for the treatment of acute upper respiratory infection in children: a systematic review and meta-analysis |
| title_sort | qingkailing injection for the treatment of acute upper respiratory infection in children a systematic review and meta analysis |
| topic | Qingkailing injection Children Acute upper respiratory infection Randomized controlled trials Meta-analysis |
| url | http://www.sciencedirect.com/science/article/pii/S2095754816300618 |
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