Microglia-Specific Promoter Activities of HEXB Gene

Microglia-Specific Promoter Activities of HEXB Gene

Adeno-associated virus (AAV)-mediated genetic targeting of microglia remains a challenge. Overcoming this hurdle is essential for gene editing in the central nervous system (CNS). Here, we characterized the minimal/native promoter of the HEXB gene, which is known to be specifically and stably expres...

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Bibliographic Details
Main Authors: Sahil Shah, Lilly M. Wong, Kendra Ellis, Brittany Bodnar, Sami Saribas, Julia Ting, Zhengyu Wei, Yuyang Tang, Xianwei Wang, Hong Wang, Binhua Ling, David M. Margolis, J. Victor Garcia, Wenhui Hu, Guochun Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Cellular Neuroscience
Subjects:
HexB
CD68
microglia
astrocytes
gene therapy
gene editing
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2022.808598/full

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