Synergistic plasticity of intrinsic conductance and electrical coupling restores synchrony in an intact motor network
Motor neurons of the crustacean cardiac ganglion generate virtually identical, synchronized output despite the fact that each neuron uses distinct conductance magnitudes. As a result of this variability, manipulations that target ionic conductances have distinct effects on neurons within the same ga...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2016-08-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/16879 |
| _version_ | 1811199752717467648 |
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| author | Brian J Lane Pranit Samarth Joseph L Ransdell Satish S Nair David J Schulz |
| author_facet | Brian J Lane Pranit Samarth Joseph L Ransdell Satish S Nair David J Schulz |
| author_sort | Brian J Lane |
| collection | DOAJ |
| description | Motor neurons of the crustacean cardiac ganglion generate virtually identical, synchronized output despite the fact that each neuron uses distinct conductance magnitudes. As a result of this variability, manipulations that target ionic conductances have distinct effects on neurons within the same ganglion, disrupting synchronized motor neuron output that is necessary for proper cardiac function. We hypothesized that robustness in network output is accomplished via plasticity that counters such destabilizing influences. By blocking high-threshold K+ conductances in motor neurons within the ongoing cardiac network, we discovered that compensation both resynchronized the network and helped restore excitability. Using model findings to guide experimentation, we determined that compensatory increases of both GA and electrical coupling restored function in the network. This is one of the first direct demonstrations of the physiological regulation of coupling conductance in a compensatory context, and of synergistic plasticity across cell- and network-level mechanisms in the restoration of output. |
| first_indexed | 2024-04-12T01:53:39Z |
| format | Article |
| id | doaj.art-54a2c8a0ffd24bb494383a691d918a90 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T01:53:39Z |
| publishDate | 2016-08-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-54a2c8a0ffd24bb494383a691d918a902022-12-22T03:52:52ZengeLife Sciences Publications LtdeLife2050-084X2016-08-01510.7554/eLife.16879Synergistic plasticity of intrinsic conductance and electrical coupling restores synchrony in an intact motor networkBrian J Lane0Pranit Samarth1Joseph L Ransdell2Satish S Nair3David J Schulz4https://orcid.org/0000-0003-4532-5362Division of Biological Sciences, University of Missouri-Columbia, Columbia, United StatesDepartment of Electrical and Computer Engineering, University of Missouri-Columbia, Columbia, United StatesDivision of Biological Sciences, University of Missouri-Columbia, Columbia, United StatesDepartment of Electrical and Computer Engineering, University of Missouri-Columbia, Columbia, United StatesDivision of Biological Sciences, University of Missouri-Columbia, Columbia, United StatesMotor neurons of the crustacean cardiac ganglion generate virtually identical, synchronized output despite the fact that each neuron uses distinct conductance magnitudes. As a result of this variability, manipulations that target ionic conductances have distinct effects on neurons within the same ganglion, disrupting synchronized motor neuron output that is necessary for proper cardiac function. We hypothesized that robustness in network output is accomplished via plasticity that counters such destabilizing influences. By blocking high-threshold K+ conductances in motor neurons within the ongoing cardiac network, we discovered that compensation both resynchronized the network and helped restore excitability. Using model findings to guide experimentation, we determined that compensatory increases of both GA and electrical coupling restored function in the network. This is one of the first direct demonstrations of the physiological regulation of coupling conductance in a compensatory context, and of synergistic plasticity across cell- and network-level mechanisms in the restoration of output.https://elifesciences.org/articles/16879cancer borealishomeostatic plasticitycompensationstomatogastricneural networkcomputational modeling |
| spellingShingle | Brian J Lane Pranit Samarth Joseph L Ransdell Satish S Nair David J Schulz Synergistic plasticity of intrinsic conductance and electrical coupling restores synchrony in an intact motor network eLife cancer borealis homeostatic plasticity compensation stomatogastric neural network computational modeling |
| title | Synergistic plasticity of intrinsic conductance and electrical coupling restores synchrony in an intact motor network |
| title_full | Synergistic plasticity of intrinsic conductance and electrical coupling restores synchrony in an intact motor network |
| title_fullStr | Synergistic plasticity of intrinsic conductance and electrical coupling restores synchrony in an intact motor network |
| title_full_unstemmed | Synergistic plasticity of intrinsic conductance and electrical coupling restores synchrony in an intact motor network |
| title_short | Synergistic plasticity of intrinsic conductance and electrical coupling restores synchrony in an intact motor network |
| title_sort | synergistic plasticity of intrinsic conductance and electrical coupling restores synchrony in an intact motor network |
| topic | cancer borealis homeostatic plasticity compensation stomatogastric neural network computational modeling |
| url | https://elifesciences.org/articles/16879 |
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