Periostin Contributes to the Pathogenesis of Atopic Dermatitis by Inducing TSLP Production from Keratinocytes

Periostin Contributes to the Pathogenesis of Atopic Dermatitis by Inducing TSLP Production from Keratinocytes

Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease where Th2-type immune responses are dominant. Keratinocytes persistently secrete proinflammatory cytokines and chemokines, amplifying Th2-type responses in AD. We have recently reported that periostin, an extracellular matrix...

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Bibliographic Details
Main Authors: Hiroshi Shiraishi, Miho Masuoka, Shoichiro Ohta, Shoichi Suzuki, Kazuhiko Arima, Kazuto Taniguchi, Shigehisa Aoki, Shuji Toda, Tomohiro Yoshimoto, Naoki Inagaki, Simon J Conway, Yutaka Narisawa, Kenji Izuhara
Format: Article
Language:English
Published: Elsevier 2012-01-01
Series:Allergology International
Subjects:
atopic dermatitis
house dust mite
periostin
Th2 cells
TSLP
Online Access:http://www.sciencedirect.com/science/article/pii/S1323893015302574

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