Ligand-Free Signaling of G-Protein-Coupled Receptors: Physiology, Pharmacology, and Genetics

G-protein-coupled receptors (GPCRs) are ubiquitous sensors and regulators of cellular functions. Each GPCR exists in complex aggregates with multiple resting and active conformations. Designed to detect weak stimuli, GPCRs can also activate spontaneously, resulting in basal ligand-free signaling. Ag...

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Библиографические подробности
Главный автор: Wolfgang Sadee
Формат: Статья
Язык:English
Опубликовано: MDPI AG 2023-08-01
Серии:Molecules
Предметы:
Online-ссылка:https://www.mdpi.com/1420-3049/28/17/6375