Morusin induces osteogenic differentiation of bone marrow mesenchymal stem cells by canonical Wnt/β-catenin pathway and prevents bone loss in an ovariectomized rat model

Morusin induces osteogenic differentiation of bone marrow mesenchymal stem cells by canonical Wnt/β-catenin pathway and prevents bone loss in an ovariectomized rat model

Abstract Background Osteoporosis (OP) is a metabolic bone disease due to the imbalance of osteogenesis and bone resorption, in which, bone marrow mesenchymal stem cells (BMSCs) have a significant effect as the seed cells. Recent research has shown the function of Morusin on inhibiting osteoclast dif...

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Bibliographic Details
Main Authors: Ming Chen, Hui Han, Siqi Zhou, Yinxian Wen, Liaobin Chen
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Stem Cell Research & Therapy
Subjects:
Morusin
BMSCs
Wnt/β-catenin
Osteoporosis
Online Access:https://doi.org/10.1186/s13287-021-02239-3

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