A Monolayer System for the Efficient Generation of Motor Neuron Progenitors and Functional Motor Neurons from Human Pluripotent Stem Cells

A Monolayer System for the Efficient Generation of Motor Neuron Progenitors and Functional Motor Neurons from Human Pluripotent Stem Cells

Methods for the conversion of human induced pluripotent stem cells (hiPSCs) into motor neurons (MNs) have opened to the generation of patient-derived in vitro systems that can be exploited for MN disease modelling. However, the lack of simplified and consistent protocols and the fact that hiPSC-deri...

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Bibliographic Details
Main Authors: Alessandro Cutarelli, Vladimir A. Martínez-Rojas, Alice Tata, Ingrid Battistella, Daniela Rossi, Daniele Arosio, Carlo Musio, Luciano Conti
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cells
Subjects:
induced pluripotent stem cells
hiPSC
spinal motor neurons
motor neuron progenitors
cellular models
spinal muscular atrophy
Online Access:https://www.mdpi.com/2073-4409/10/5/1127

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