Tuberculosis drugs' distribution and emergence of resistance in patient's lung lesions: A mechanistic model and tool for regimen and dose optimization.
<h4>Background</h4>The sites of mycobacterial infection in the lungs of tuberculosis (TB) patients have complex structures and poor vascularization, which obstructs drug distribution to these hard-to-reach and hard-to-treat disease sites, further leading to suboptimal drug concentrations...
Main Authors: | Natasha Strydom, Sneha V Gupta, William S Fox, Laura E Via, Hyeeun Bang, Myungsun Lee, Seokyong Eum, TaeSun Shim, Clifton E Barry, Matthew Zimmerman, Véronique Dartois, Radojka M Savic |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2019-04-01
|
Series: | PLoS Medicine |
Online Access: | https://doi.org/10.1371/journal.pmed.1002773 |
Similar Items
-
Mathematical model of oxygen, nutrient, and drug transport in tuberculosis granulomas.
by: Meenal Datta, et al.
Published: (2024-02-01) -
A systematic efficacy analysis of tuberculosis treatment with BPaL‐containing regimens using a multiscale modeling approach
by: Maral Budak, et al.
Published: (2024-04-01) -
Optimizing tuberculosis treatment efficacy: Comparing the standard regimen with Moxifloxacin-containing regimens.
by: Maral Budak, et al.
Published: (2023-06-01) -
The efficacy of performing shockwave lithotripsy before retrograde intrarenal surgery in the treatment of multiple or large (≥1.5 cm) nephrolithiasis: A propensity score matched analysis
by: Myungsun Shim, et al.
Published: (2017-01-01) -
Optimizing vaccine dosing kinetics for stronger antibody response
by: Kang, Myungsun(Myungsun Sunny)
Published: (2020)