Fibrinogen status in relapse and remission of childhood nephrotic syndrome
Objective To evaluate fibrinogen concentration of relapsing neph- rotic syndrome (NS) in children, and to investigate relationship between fibrinogen with albumin and cholesterol. Methods A cross-sectional study among NS patients admitted to pediatric outpatient clinic and pediatric ward at Sanglah...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Indonesian Pediatric Society Publishing House
2016-10-01
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| Series: | Paediatrica Indonesiana |
| Subjects: | |
| Online Access: | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/919 |
| _version_ | 1818110841734561792 |
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| author | Veronica Lily Limantara Ida Bagus Mudita I Ketut Suarta |
| author_facet | Veronica Lily Limantara Ida Bagus Mudita I Ketut Suarta |
| author_sort | Veronica Lily Limantara |
| collection | DOAJ |
| description | Objective To evaluate fibrinogen concentration of relapsing neph-
rotic syndrome (NS) in children, and to investigate relationship
between fibrinogen with albumin and cholesterol.
Methods A cross-sectional study among NS patients admitted to
pediatric outpatient clinic and pediatric ward at Sanglah Hospital,
Denpasar, from November 1, 2003 to January 31, 2004. All pa-
tients were evaluated for clinical and laboratory findings of relapse
and remission, including edema, proteinuria, serum albumin, total
cholesterol, as well as total platelet count and fibrinogen concen-
tration to evaluate coagulation parameters in nephrotic patients.
Results There were 36 patients with the mean age of 7.4 (SD 2.3)
years included in this study. Mean fibrinogen concentration in re-
lapse state was 671.8 (SD 102.7) mg/dl, while in remission state
was 255.2 (SD 50.5 mg/dl); the mean difference was 416.6 mg/dl
(95% CI 362.9;470.4; P<0.001). Fibrinogen was inversely and
strongly correlated with serum albumin concentrations (r=-0.91;
P<0.001). Fibrinogen was positively and strongly correlated to to-
tal cholesterol (r=0.80; P<0.001). Using multiple regression analy-
sis, it was shown that only relapse/remission status was signifi-
cantly associated with fibrinogen concentration (P<0.001).
Conclusion Fibrinogen status is significantly correlated with re-
lapse and remission status of NS in childhood patients. |
| first_indexed | 2024-12-11T02:53:34Z |
| format | Article |
| id | doaj.art-54a9deaea233420fa84f9d5d9cf0ce16 |
| institution | Directory Open Access Journal |
| issn | 0030-9311 2338-476X |
| language | English |
| last_indexed | 2024-12-11T02:53:34Z |
| publishDate | 2016-10-01 |
| publisher | Indonesian Pediatric Society Publishing House |
| record_format | Article |
| series | Paediatrica Indonesiana |
| spelling | doaj.art-54a9deaea233420fa84f9d5d9cf0ce162022-12-22T01:23:14ZengIndonesian Pediatric Society Publishing HousePaediatrica Indonesiana0030-93112338-476X2016-10-014641495310.14238/pi46.4.2006.149-53775Fibrinogen status in relapse and remission of childhood nephrotic syndromeVeronica Lily LimantaraIda Bagus MuditaI Ketut SuartaObjective To evaluate fibrinogen concentration of relapsing neph- rotic syndrome (NS) in children, and to investigate relationship between fibrinogen with albumin and cholesterol. Methods A cross-sectional study among NS patients admitted to pediatric outpatient clinic and pediatric ward at Sanglah Hospital, Denpasar, from November 1, 2003 to January 31, 2004. All pa- tients were evaluated for clinical and laboratory findings of relapse and remission, including edema, proteinuria, serum albumin, total cholesterol, as well as total platelet count and fibrinogen concen- tration to evaluate coagulation parameters in nephrotic patients. Results There were 36 patients with the mean age of 7.4 (SD 2.3) years included in this study. Mean fibrinogen concentration in re- lapse state was 671.8 (SD 102.7) mg/dl, while in remission state was 255.2 (SD 50.5 mg/dl); the mean difference was 416.6 mg/dl (95% CI 362.9;470.4; P<0.001). Fibrinogen was inversely and strongly correlated with serum albumin concentrations (r=-0.91; P<0.001). Fibrinogen was positively and strongly correlated to to- tal cholesterol (r=0.80; P<0.001). Using multiple regression analy- sis, it was shown that only relapse/remission status was signifi- cantly associated with fibrinogen concentration (P<0.001). Conclusion Fibrinogen status is significantly correlated with re- lapse and remission status of NS in childhood patients.https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/919nephrotic syndromefibrinogenchildren |
| spellingShingle | Veronica Lily Limantara Ida Bagus Mudita I Ketut Suarta Fibrinogen status in relapse and remission of childhood nephrotic syndrome Paediatrica Indonesiana nephrotic syndrome fibrinogen children |
| title | Fibrinogen status in relapse and remission of childhood nephrotic syndrome |
| title_full | Fibrinogen status in relapse and remission of childhood nephrotic syndrome |
| title_fullStr | Fibrinogen status in relapse and remission of childhood nephrotic syndrome |
| title_full_unstemmed | Fibrinogen status in relapse and remission of childhood nephrotic syndrome |
| title_short | Fibrinogen status in relapse and remission of childhood nephrotic syndrome |
| title_sort | fibrinogen status in relapse and remission of childhood nephrotic syndrome |
| topic | nephrotic syndrome fibrinogen children |
| url | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/919 |
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