The CLAVATA receptor FASCIATED EAR2 responds to distinct CLE peptides by signaling through two downstream effectors
Meristems contain groups of indeterminate stem cells, which are maintained by a feedback loop between CLAVATA (CLV) and WUSCHEL (WUS) signaling. CLV signaling involves the secretion of the CLV3 peptide and its perception by a number of Leucine-Rich-Repeat (LRR) receptors, including the receptor-like...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2018-03-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/35673 |
| _version_ | 1828381048286740480 |
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| author | Byoung Il Je Fang Xu Qingyu Wu Lei Liu Robert Meeley Joseph P Gallagher Leo Corcilius Richard J Payne Madelaine E Bartlett David Jackson |
| author_facet | Byoung Il Je Fang Xu Qingyu Wu Lei Liu Robert Meeley Joseph P Gallagher Leo Corcilius Richard J Payne Madelaine E Bartlett David Jackson |
| author_sort | Byoung Il Je |
| collection | DOAJ |
| description | Meristems contain groups of indeterminate stem cells, which are maintained by a feedback loop between CLAVATA (CLV) and WUSCHEL (WUS) signaling. CLV signaling involves the secretion of the CLV3 peptide and its perception by a number of Leucine-Rich-Repeat (LRR) receptors, including the receptor-like kinase CLV1 and the receptor-like protein CLV2 coupled with the CORYNE (CRN) pseudokinase. CLV2, and its maize ortholog FASCIATED EAR2 (FEA2) appear to function in signaling by CLV3 and several related CLV3/EMBRYO-SURROUNDING REGION (CLE) peptide ligands. Nevertheless, how signaling specificity is achieved remains unknown. Here we show that FEA2 transmits signaling from two distinct CLE peptides, the maize CLV3 ortholog ZmCLE7 and ZmFON2-LIKE CLE PROTEIN1 (ZmFCP1) through two different candidate downstream effectors, the alpha subunit of the maize heterotrimeric G protein COMPACT PLANT2 (CT2), and ZmCRN. Our data provide a novel framework to understand how diverse signaling peptides can activate different downstream pathways through common receptor proteins. |
| first_indexed | 2024-12-10T04:09:24Z |
| format | Article |
| id | doaj.art-54aab292b7de422fa60bd9f1be0c356e |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-12-10T04:09:24Z |
| publishDate | 2018-03-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-54aab292b7de422fa60bd9f1be0c356e2022-12-22T02:02:47ZengeLife Sciences Publications LtdeLife2050-084X2018-03-01710.7554/eLife.35673The CLAVATA receptor FASCIATED EAR2 responds to distinct CLE peptides by signaling through two downstream effectorsByoung Il Je0https://orcid.org/0000-0002-6661-5855Fang Xu1https://orcid.org/0000-0003-0767-1272Qingyu Wu2https://orcid.org/0000-0003-3064-2445Lei Liu3Robert Meeley4https://orcid.org/0000-0002-4496-1888Joseph P Gallagher5Leo Corcilius6Richard J Payne7https://orcid.org/0000-0002-3618-9226Madelaine E Bartlett8David Jackson9https://orcid.org/0000-0002-4269-7649Cold Spring Harbor Laboratory, Cold Spring Harbor, United States; Department of Horticultural Bioscience, College of Natural Resource and Life Science, Pusan National University, Miryang, Republic of KoreaCold Spring Harbor Laboratory, Cold Spring Harbor, United StatesCold Spring Harbor Laboratory, Cold Spring Harbor, United StatesCold Spring Harbor Laboratory, Cold Spring Harbor, United StatesDuPont Pioneer, Agricultural Biotechnology, Johnston, United StatesUniversity of Massachusetts Amherst, Amherst, United StatesThe University of Sydney, Camperdown, AustraliaThe University of Sydney, Camperdown, AustraliaUniversity of Massachusetts Amherst, Amherst, United StatesCold Spring Harbor Laboratory, Cold Spring Harbor, United StatesMeristems contain groups of indeterminate stem cells, which are maintained by a feedback loop between CLAVATA (CLV) and WUSCHEL (WUS) signaling. CLV signaling involves the secretion of the CLV3 peptide and its perception by a number of Leucine-Rich-Repeat (LRR) receptors, including the receptor-like kinase CLV1 and the receptor-like protein CLV2 coupled with the CORYNE (CRN) pseudokinase. CLV2, and its maize ortholog FASCIATED EAR2 (FEA2) appear to function in signaling by CLV3 and several related CLV3/EMBRYO-SURROUNDING REGION (CLE) peptide ligands. Nevertheless, how signaling specificity is achieved remains unknown. Here we show that FEA2 transmits signaling from two distinct CLE peptides, the maize CLV3 ortholog ZmCLE7 and ZmFON2-LIKE CLE PROTEIN1 (ZmFCP1) through two different candidate downstream effectors, the alpha subunit of the maize heterotrimeric G protein COMPACT PLANT2 (CT2), and ZmCRN. Our data provide a novel framework to understand how diverse signaling peptides can activate different downstream pathways through common receptor proteins.https://elifesciences.org/articles/35673Shoot Apical MeristemPlant DevelopmentCLAVATA signaling |
| spellingShingle | Byoung Il Je Fang Xu Qingyu Wu Lei Liu Robert Meeley Joseph P Gallagher Leo Corcilius Richard J Payne Madelaine E Bartlett David Jackson The CLAVATA receptor FASCIATED EAR2 responds to distinct CLE peptides by signaling through two downstream effectors eLife Shoot Apical Meristem Plant Development CLAVATA signaling |
| title | The CLAVATA receptor FASCIATED EAR2 responds to distinct CLE peptides by signaling through two downstream effectors |
| title_full | The CLAVATA receptor FASCIATED EAR2 responds to distinct CLE peptides by signaling through two downstream effectors |
| title_fullStr | The CLAVATA receptor FASCIATED EAR2 responds to distinct CLE peptides by signaling through two downstream effectors |
| title_full_unstemmed | The CLAVATA receptor FASCIATED EAR2 responds to distinct CLE peptides by signaling through two downstream effectors |
| title_short | The CLAVATA receptor FASCIATED EAR2 responds to distinct CLE peptides by signaling through two downstream effectors |
| title_sort | clavata receptor fasciated ear2 responds to distinct cle peptides by signaling through two downstream effectors |
| topic | Shoot Apical Meristem Plant Development CLAVATA signaling |
| url | https://elifesciences.org/articles/35673 |
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