Supplementation with biscuits enriched with hesperidin and naringenin is associated with an improvement of the Metabolic Syndrome induced by a cafeteria diet in rats
Metabolic syndrome (MetS) has become a major public health concern. Because of their numerous health-promoting biological properties, polyphenols are potential candidates to ameliorate MetS and, recently, the incorporation of these compounds into widely consumed foodstuffs has emerged as a potential...
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| Format: | Article |
| Language: | English |
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Elsevier
2019-10-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464619304281 |
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| author | Jordi Mayneris-Perxachs Juan Maria Alcaide-Hidalgo Esther de la Hera Josep Maria del Bas Lluís Arola Antoni Caimari |
| author_facet | Jordi Mayneris-Perxachs Juan Maria Alcaide-Hidalgo Esther de la Hera Josep Maria del Bas Lluís Arola Antoni Caimari |
| author_sort | Jordi Mayneris-Perxachs |
| collection | DOAJ |
| description | Metabolic syndrome (MetS) has become a major public health concern. Because of their numerous health-promoting biological properties, polyphenols are potential candidates to ameliorate MetS and, recently, the incorporation of these compounds into widely consumed foodstuffs has emerged as a potential strategy to enhance their intake. Therefore, we aimed to assess the potential beneficial effects of biscuits enriched with the citrus polyphenols hesperidin and naringenin (HN) in rats that were fed either standard chow (STD) or an obesogenic cafeteria diet (CAF) for 16 weeks. The STD and CAF groups were supplemented with either control or HN biscuits for the final 8 weeks of the study. CAF-fed rats developed MetS, characterized by obesity, insulin resistance, hypertension and dyslipidemia. HN supplementation in CAF-fed rats ameliorated hypertension and insulin resistance and significantly reduced body weight, mesenteric adiposity, total cholesterol, LDL-C and oxidative stress. Hence, HN biscuits may be a promising functional food against MetS. |
| first_indexed | 2024-12-14T01:13:44Z |
| format | Article |
| id | doaj.art-54ab1cf8d14b427a966435704663a364 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-14T01:13:44Z |
| publishDate | 2019-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-54ab1cf8d14b427a966435704663a3642022-12-21T23:22:40ZengElsevierJournal of Functional Foods1756-46462019-10-0161Supplementation with biscuits enriched with hesperidin and naringenin is associated with an improvement of the Metabolic Syndrome induced by a cafeteria diet in ratsJordi Mayneris-Perxachs0Juan Maria Alcaide-Hidalgo1Esther de la Hera2Josep Maria del Bas3Lluís Arola4Antoni Caimari5Centre for Omic Sciences, Joint Unit Universitat Rovira i Virgili-EURECAT, Centre Tecnològic de Catalunya, Unique Scientific and Technical Infrastructures, Reus, Spain; Eurecat, Centre Tecnològic de Catalunya, Technological Unit of Nutrition and Health, Reus, SpainEurecat, Centre Tecnològic de Catalunya, Technological Unit of Nutrition and Health, Reus, SpainIMASDEA, Research and Development Centre, El Espinar – Segovia, SpainEurecat, Centre Tecnològic de Catalunya, Technological Unit of Nutrition and Health, Reus, SpainCentre for Omic Sciences, Joint Unit Universitat Rovira i Virgili-EURECAT, Centre Tecnològic de Catalunya, Unique Scientific and Technical Infrastructures, Reus, Spain; Eurecat, Centre Tecnològic de Catalunya, Technological Unit of Nutrition and Health, Reus, Spain; Universitat Rovira i Virgili, Nutrigenomics Research Group, Department of Biochemistry and Biotechnology, Campus Sescelades, Tarragona, Spain; Corresponding author at: Eurecat, Centre Tecnològic de Catalunya, Biotechnology Area, Avinguda Universitat, 1, 43204 Reus, Spain.Centre for Omic Sciences, Joint Unit Universitat Rovira i Virgili-EURECAT, Centre Tecnològic de Catalunya, Unique Scientific and Technical Infrastructures, Reus, Spain; Eurecat, Centre Tecnològic de Catalunya, Technological Unit of Nutrition and Health, Reus, SpainMetabolic syndrome (MetS) has become a major public health concern. Because of their numerous health-promoting biological properties, polyphenols are potential candidates to ameliorate MetS and, recently, the incorporation of these compounds into widely consumed foodstuffs has emerged as a potential strategy to enhance their intake. Therefore, we aimed to assess the potential beneficial effects of biscuits enriched with the citrus polyphenols hesperidin and naringenin (HN) in rats that were fed either standard chow (STD) or an obesogenic cafeteria diet (CAF) for 16 weeks. The STD and CAF groups were supplemented with either control or HN biscuits for the final 8 weeks of the study. CAF-fed rats developed MetS, characterized by obesity, insulin resistance, hypertension and dyslipidemia. HN supplementation in CAF-fed rats ameliorated hypertension and insulin resistance and significantly reduced body weight, mesenteric adiposity, total cholesterol, LDL-C and oxidative stress. Hence, HN biscuits may be a promising functional food against MetS.http://www.sciencedirect.com/science/article/pii/S1756464619304281Metabolic SyndromeCafeteria dietPolyphenolsCitrus flavanonesHesperidinNaringenin |
| spellingShingle | Jordi Mayneris-Perxachs Juan Maria Alcaide-Hidalgo Esther de la Hera Josep Maria del Bas Lluís Arola Antoni Caimari Supplementation with biscuits enriched with hesperidin and naringenin is associated with an improvement of the Metabolic Syndrome induced by a cafeteria diet in rats Journal of Functional Foods Metabolic Syndrome Cafeteria diet Polyphenols Citrus flavanones Hesperidin Naringenin |
| title | Supplementation with biscuits enriched with hesperidin and naringenin is associated with an improvement of the Metabolic Syndrome induced by a cafeteria diet in rats |
| title_full | Supplementation with biscuits enriched with hesperidin and naringenin is associated with an improvement of the Metabolic Syndrome induced by a cafeteria diet in rats |
| title_fullStr | Supplementation with biscuits enriched with hesperidin and naringenin is associated with an improvement of the Metabolic Syndrome induced by a cafeteria diet in rats |
| title_full_unstemmed | Supplementation with biscuits enriched with hesperidin and naringenin is associated with an improvement of the Metabolic Syndrome induced by a cafeteria diet in rats |
| title_short | Supplementation with biscuits enriched with hesperidin and naringenin is associated with an improvement of the Metabolic Syndrome induced by a cafeteria diet in rats |
| title_sort | supplementation with biscuits enriched with hesperidin and naringenin is associated with an improvement of the metabolic syndrome induced by a cafeteria diet in rats |
| topic | Metabolic Syndrome Cafeteria diet Polyphenols Citrus flavanones Hesperidin Naringenin |
| url | http://www.sciencedirect.com/science/article/pii/S1756464619304281 |
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