Effects of Poly(Amidoamine) Dendrimer-Coated Mesoporous Bioactive Glass Nanoparticles on Dentin Remineralization
Dentin hypersensitivity (DH) is one of the most common clinical conditions usually associated with exposed dentinal surfaces. In this study, we identified the effectiveness of poly(amidoamine) (PAMAM) dendrimer-coated mesoporous bioactive glass nanoparticles (MBN) (PAMAM@MBN) on DH treatment, examin...
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| Format: | Article |
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MDPI AG
2019-04-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/9/4/591 |
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| author | Jungin Bae Woo-Sung Son Kyung-Hyeon Yoo Seog-Young Yoon Moon-Kyoung Bae Dong Joon Lee Ching-Chang Ko Youn-Kyung Choi Yong-Il Kim |
| author_facet | Jungin Bae Woo-Sung Son Kyung-Hyeon Yoo Seog-Young Yoon Moon-Kyoung Bae Dong Joon Lee Ching-Chang Ko Youn-Kyung Choi Yong-Il Kim |
| author_sort | Jungin Bae |
| collection | DOAJ |
| description | Dentin hypersensitivity (DH) is one of the most common clinical conditions usually associated with exposed dentinal surfaces. In this study, we identified the effectiveness of poly(amidoamine) (PAMAM) dendrimer-coated mesoporous bioactive glass nanoparticles (MBN) (PAMAM@MBN) on DH treatment, examining the ion-releasing effect, dentin remineralization, and the occluding effect of dentinal tubules. We synthesized MBN and PAMAM@MBN. After soaking each sample in simulated body fluid (SBF), we observed ion-releasing effects and dentin remineralization effects for 30 days. Also, we prepared 30 premolars to find the ratio of occluded dentinal tubules after applying MBN and PAMAM@MBN, respectively. The results showed that PAMAM did not disrupt the calcium ion-releasing ability or the dentin remineralization of MBN. The PAMAM@MBN showed a better occluding effect for dentinal tubules than that of MBN (<i>p</i> < 0.05). In terms of dentinal tubule occlusion, the gap between MBN was well occluded due to PAMAM. This implies that PAMAM@MBN could be effectively used in dentinal tubule sealing and remineralization. |
| first_indexed | 2024-04-12T05:30:04Z |
| format | Article |
| id | doaj.art-54ab6c3e53de4b9785bd5790cbb0160b |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-04-12T05:30:04Z |
| publishDate | 2019-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-54ab6c3e53de4b9785bd5790cbb0160b2022-12-22T03:46:06ZengMDPI AGNanomaterials2079-49912019-04-019459110.3390/nano9040591nano9040591Effects of Poly(Amidoamine) Dendrimer-Coated Mesoporous Bioactive Glass Nanoparticles on Dentin RemineralizationJungin Bae0Woo-Sung Son1Kyung-Hyeon Yoo2Seog-Young Yoon3Moon-Kyoung Bae4Dong Joon Lee5Ching-Chang Ko6Youn-Kyung Choi7Yong-Il Kim8Department of Orthodontics, Dental Research Institute, Pusan National University Dental Hospital, Yangsan 50612, KoreaDepartment of Orthodontics, Dental Research Institute, Pusan National University Dental Hospital, Yangsan 50612, KoreaSchool of Materials Science and Engineering, Pusan National University, Busan 46241, KoreaSchool of Materials Science and Engineering, Pusan National University, Busan 46241, KoreaDepartment of Oral Physiology, School of Dentistry, Pusan National University, Yangsan 50612, KoreaOral and Craniofacial Health Sciences Research, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516, USADepartment of Orthodontics, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516, USADepartment of Orthodontics, Biomedical Research Institute, Pusan National University Hospital, Busan 49241, KoreaDepartment of Orthodontics, Dental Research Institute, Pusan National University Dental Hospital, Yangsan 50612, KoreaDentin hypersensitivity (DH) is one of the most common clinical conditions usually associated with exposed dentinal surfaces. In this study, we identified the effectiveness of poly(amidoamine) (PAMAM) dendrimer-coated mesoporous bioactive glass nanoparticles (MBN) (PAMAM@MBN) on DH treatment, examining the ion-releasing effect, dentin remineralization, and the occluding effect of dentinal tubules. We synthesized MBN and PAMAM@MBN. After soaking each sample in simulated body fluid (SBF), we observed ion-releasing effects and dentin remineralization effects for 30 days. Also, we prepared 30 premolars to find the ratio of occluded dentinal tubules after applying MBN and PAMAM@MBN, respectively. The results showed that PAMAM did not disrupt the calcium ion-releasing ability or the dentin remineralization of MBN. The PAMAM@MBN showed a better occluding effect for dentinal tubules than that of MBN (<i>p</i> < 0.05). In terms of dentinal tubule occlusion, the gap between MBN was well occluded due to PAMAM. This implies that PAMAM@MBN could be effectively used in dentinal tubule sealing and remineralization.https://www.mdpi.com/2079-4991/9/4/591PAMAMmesoporous bioactive glassdentin hypersensitivitydentinal tubule occlusion |
| spellingShingle | Jungin Bae Woo-Sung Son Kyung-Hyeon Yoo Seog-Young Yoon Moon-Kyoung Bae Dong Joon Lee Ching-Chang Ko Youn-Kyung Choi Yong-Il Kim Effects of Poly(Amidoamine) Dendrimer-Coated Mesoporous Bioactive Glass Nanoparticles on Dentin Remineralization Nanomaterials PAMAM mesoporous bioactive glass dentin hypersensitivity dentinal tubule occlusion |
| title | Effects of Poly(Amidoamine) Dendrimer-Coated Mesoporous Bioactive Glass Nanoparticles on Dentin Remineralization |
| title_full | Effects of Poly(Amidoamine) Dendrimer-Coated Mesoporous Bioactive Glass Nanoparticles on Dentin Remineralization |
| title_fullStr | Effects of Poly(Amidoamine) Dendrimer-Coated Mesoporous Bioactive Glass Nanoparticles on Dentin Remineralization |
| title_full_unstemmed | Effects of Poly(Amidoamine) Dendrimer-Coated Mesoporous Bioactive Glass Nanoparticles on Dentin Remineralization |
| title_short | Effects of Poly(Amidoamine) Dendrimer-Coated Mesoporous Bioactive Glass Nanoparticles on Dentin Remineralization |
| title_sort | effects of poly amidoamine dendrimer coated mesoporous bioactive glass nanoparticles on dentin remineralization |
| topic | PAMAM mesoporous bioactive glass dentin hypersensitivity dentinal tubule occlusion |
| url | https://www.mdpi.com/2079-4991/9/4/591 |
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