Effect of 3,4-Methylenedioxymethamphetamine on Liver CYP2C19 Enzyme Activity in Isolated Perfused Rat Liver Using Omeprazole Probe

Effect of 3,4-Methylenedioxymethamphetamine on Liver CYP2C19 Enzyme Activity in Isolated Perfused Rat Liver Using Omeprazole Probe

Background and purpose: This study aimed at investigating the effects of 3,4-Methyl​enedioxy​methamphetamine (MDMA) on liver cytochrome 2C19 enzyme activity, which is a major liver enzyme in the metabolism of a wide range of drugs, using omeprazole as a probe of the CYP2C19 activity in isolated perf...

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Bibliographic Details
Main Authors: Mohammadreza Rouini, Navid Neyshaburinezhad, Alireza Foroumadi, Hoda Lavasani, Yalda Hosseinzadeh Ardakani
Format: Article
Language:English
Published: Mazandaran University of Medical Sciences 2020-07-01
Series:Journal of Mazandaran University of Medical Sciences
Subjects:
metabolism
mdma
omeprazole
liver perfusion
cyp2c199
Online Access:http://jmums.mazums.ac.ir/article-1-14167-en.html

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