Hepatic Hemangiomas Alter Morphometry and Impair Hemodynamics of the Abdominal Aorta and Primary Branches From Computer Simulations
Background: The formation of hepatic hemangiomas (HH) is associated with VEGF and IL-7 that alter conduit arteries and small arterioles. To our knowledge, there are no studies to investigate the effects of HH on the hemodynamics in conduit arteries. The aim of the study is to perform morphometric an...
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Frontiers Media S.A.
2018-04-01
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| Series: | Frontiers in Physiology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fphys.2018.00334/full |
| _version_ | 1819111799960633344 |
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| author | Xiaoping Yin Xu Huang Qiao Li Li Li Pei Niu Minglu Cao Fei Guo Xuechao Li Wenchang Tan Wenchang Tan Wenchang Tan Yunlong Huo Yunlong Huo Yunlong Huo |
| author_facet | Xiaoping Yin Xu Huang Qiao Li Li Li Pei Niu Minglu Cao Fei Guo Xuechao Li Wenchang Tan Wenchang Tan Wenchang Tan Yunlong Huo Yunlong Huo Yunlong Huo |
| author_sort | Xiaoping Yin |
| collection | DOAJ |
| description | Background: The formation of hepatic hemangiomas (HH) is associated with VEGF and IL-7 that alter conduit arteries and small arterioles. To our knowledge, there are no studies to investigate the effects of HH on the hemodynamics in conduit arteries. The aim of the study is to perform morphometric and hemodynamic analysis in abdominal conduit arteries and bifurcations of HH patients and controls.Methods: Based on morphometry reconstructed from CT images, geometrical models were meshed with prismatic elements for the near wall region and tetrahedral and hexahedral elements for the core region. Simulations were performed for computation of the non-Newtonian blood flow using the Carreau-Yasuda model, based on which multiple hemodynamic parameters were determined.Results: There was an increase of the lumen size, diameter ratio, and curvature in the abdominal arterial tree of HH patients as compared with controls. This significantly increased the surface area ratio of low time-averaged wall shear stress (i.e., SAR-TAWSS =Surface areaTAWSS≤4 dynes·cm−2Total surface area× 100%) (24.1 ± 7.9 vs. 5 ± 6%, 11.6 ± 12.8 vs. < 0.1%, and 44.5 ± 9.2 vs. 21 ± 24% at hepatic bifurcations, common hepatic arteries, and abdominal aortas, respectively, between HH and control patients).Conclusions: Morphometric changes caused by HH significantly deteriorated the hemodynamic environment in abdominal conduit arteries and bifurcations, which could be an important risk factor for the incidence and progression of vascular diseases. |
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| language | English |
| last_indexed | 2024-12-22T04:03:22Z |
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| series | Frontiers in Physiology |
| spelling | doaj.art-54aec85f546a40089e835d1a5720a21d2022-12-21T18:39:41ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2018-04-01910.3389/fphys.2018.00334337568Hepatic Hemangiomas Alter Morphometry and Impair Hemodynamics of the Abdominal Aorta and Primary Branches From Computer SimulationsXiaoping Yin0Xu Huang1Qiao Li2Li Li3Pei Niu4Minglu Cao5Fei Guo6Xuechao Li7Wenchang Tan8Wenchang Tan9Wenchang Tan10Yunlong Huo11Yunlong Huo12Yunlong Huo13Department of Radiology, Affiliated Hospital of Hebei University, Hebei University, Baoding, ChinaDepartment of Mechanics and Engineering Science, College of Engineering, Peking University, Beijing, ChinaDepartment of Mechanics and Engineering Science, College of Engineering, Peking University, Beijing, ChinaDepartment of Mechanics and Engineering Science, College of Engineering, Peking University, Beijing, ChinaDepartment of Mechanics and Engineering Science, College of Engineering, Peking University, Beijing, ChinaDepartment of Mechanics and Engineering Science, College of Engineering, Peking University, Beijing, ChinaCollege of Medicine, Hebei University, Baoding, ChinaCollege of Medicine, Hebei University, Baoding, ChinaDepartment of Mechanics and Engineering Science, College of Engineering, Peking University, Beijing, ChinaPKU-HKUST Shenzhen-Hongkong Institution, Shenzhen, ChinaShenzhen Graduate School, Peking University, Shenzhen, ChinaDepartment of Mechanics and Engineering Science, College of Engineering, Peking University, Beijing, ChinaCollege of Medicine, Hebei University, Baoding, ChinaPKU-HKUST Shenzhen-Hongkong Institution, Shenzhen, ChinaBackground: The formation of hepatic hemangiomas (HH) is associated with VEGF and IL-7 that alter conduit arteries and small arterioles. To our knowledge, there are no studies to investigate the effects of HH on the hemodynamics in conduit arteries. The aim of the study is to perform morphometric and hemodynamic analysis in abdominal conduit arteries and bifurcations of HH patients and controls.Methods: Based on morphometry reconstructed from CT images, geometrical models were meshed with prismatic elements for the near wall region and tetrahedral and hexahedral elements for the core region. Simulations were performed for computation of the non-Newtonian blood flow using the Carreau-Yasuda model, based on which multiple hemodynamic parameters were determined.Results: There was an increase of the lumen size, diameter ratio, and curvature in the abdominal arterial tree of HH patients as compared with controls. This significantly increased the surface area ratio of low time-averaged wall shear stress (i.e., SAR-TAWSS =Surface areaTAWSS≤4 dynes·cm−2Total surface area× 100%) (24.1 ± 7.9 vs. 5 ± 6%, 11.6 ± 12.8 vs. < 0.1%, and 44.5 ± 9.2 vs. 21 ± 24% at hepatic bifurcations, common hepatic arteries, and abdominal aortas, respectively, between HH and control patients).Conclusions: Morphometric changes caused by HH significantly deteriorated the hemodynamic environment in abdominal conduit arteries and bifurcations, which could be an important risk factor for the incidence and progression of vascular diseases.http://journal.frontiersin.org/article/10.3389/fphys.2018.00334/fullhepatic hemangiomacomputer tomographyabdominal arterial treehemodynamicsmorphology |
| spellingShingle | Xiaoping Yin Xu Huang Qiao Li Li Li Pei Niu Minglu Cao Fei Guo Xuechao Li Wenchang Tan Wenchang Tan Wenchang Tan Yunlong Huo Yunlong Huo Yunlong Huo Hepatic Hemangiomas Alter Morphometry and Impair Hemodynamics of the Abdominal Aorta and Primary Branches From Computer Simulations Frontiers in Physiology hepatic hemangioma computer tomography abdominal arterial tree hemodynamics morphology |
| title | Hepatic Hemangiomas Alter Morphometry and Impair Hemodynamics of the Abdominal Aorta and Primary Branches From Computer Simulations |
| title_full | Hepatic Hemangiomas Alter Morphometry and Impair Hemodynamics of the Abdominal Aorta and Primary Branches From Computer Simulations |
| title_fullStr | Hepatic Hemangiomas Alter Morphometry and Impair Hemodynamics of the Abdominal Aorta and Primary Branches From Computer Simulations |
| title_full_unstemmed | Hepatic Hemangiomas Alter Morphometry and Impair Hemodynamics of the Abdominal Aorta and Primary Branches From Computer Simulations |
| title_short | Hepatic Hemangiomas Alter Morphometry and Impair Hemodynamics of the Abdominal Aorta and Primary Branches From Computer Simulations |
| title_sort | hepatic hemangiomas alter morphometry and impair hemodynamics of the abdominal aorta and primary branches from computer simulations |
| topic | hepatic hemangioma computer tomography abdominal arterial tree hemodynamics morphology |
| url | http://journal.frontiersin.org/article/10.3389/fphys.2018.00334/full |
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