Influence of Polymorphisms Involved in Platelet Activation and Inflammatory Response on Aspirin-Related Upper Gastrointestinal Bleeding: A Case-Control Study

Influence of Polymorphisms Involved in Platelet Activation and Inflammatory Response on Aspirin-Related Upper Gastrointestinal Bleeding: A Case-Control Study

BackgroundDespite the wide benefits of aspirin and its cost-effectiveness, aspirin prescriptions have been reduced due to idiosyncratic responses in susceptible individuals. Low-dose aspirin and single-nucleotide polymorphisms (SNPs) are independently associated with increased risk of gastrointestin...

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Main Authors: Narmeen Mallah, Maruxa Zapata-Cachafeiro, Carmelo Aguirre, Eguzkiñe Ibarra-García, Itziar Palacios–Zabalza, Fernando Macías-García, J. Enrique Domínguez-Muñoz, María Piñeiro-Lamas, Luisa Ibáñez, Xavier Vidal, Lourdes Vendrell, Luis Martin-Arias, María Sáinz-Gil, Verónica Velasco-González, Adolfo Figueiras
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Pharmacology
Subjects:
aspirin
upper gastrointestinal haemorrhage
genetic polymorphism
pharmacogenomics
platelet
interaction
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00860/full

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